p-Coumaric acid
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p-Coumaric acid
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CAS No:
7400-08-0
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Formula:
C9H8O3
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Chemical Name:
p-Coumaric acid
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Synonyms:
2-Propenoic acid,3-(4-hydroxyphenyl)-;Cinnamic acid,p-hydroxy-;3-(4-Hydroxyphenyl)-2-propenoic acid;p-Coumaric acid;p-Hydroxycinnamic acid;p-Hydroxyphenylacrylic acid;4-Hydroxycinnamic acid;p-Cumaric acid;β-[4-Hydroxyphenyl]acrylic acid;4-Coumaric acid;4′-Hydroxycinnamic acid;NSC 59260;NSC 674321;3-(4-Hydroxyphenyl)acrylic acid
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CAS No:
Description
p-Hydroxycinnamic acid, a common dietary phenol, could inhibit platelet activity, with IC50s of 371 μM, 126 μM for thromboxane B2 production and lipopolysaccharide-induced prostaglandin E2 generation, respectively.
p-Coumaric Acid is the hydroxy derivative of Cinnamic Acid with antioxidant properties. p-Coumaric acid is a is a major component of lignocellulose. Studies suggest that p-Coumaric Acid may reduce the risk of cancer by reducing the formation of carcinogenic nitrosamines.
Safety Information
2
36/37/38
26-36-36/37/39-22
GD9095000
Xi
P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501
H315
Toxicity
| Name | Type of Test | Exposure Route | Species Observed | Dose/Duration | Toxic Effects | Reference |
|---|---|---|---|---|---|---|
| ACUTE TOXICITY DATA | LD50 - Lethal dose, 50 percent kill | Intraperitoneal | Rodent - mouse | 657 mg/kg | Details of toxic effects not reported other than lethal dose value-- | Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 104,793,1984 |
| ACUTE TOXICITY DATA | TDLo - Lowest published toxic dose | Oral | Rodent - rat | 2800 mg/kg,male 56 day(s) pre-mating | Reproductive-Paternal Effects-testes, epididymis, sperm duct Reproductive-Paternal Effects-prostate, seminal vesicle, Cowper's gland, accessory glands Reproductive-Fertility-mating performance (e.g. # sperm positive females per # females mated; # copulations per # estrus cycles) |
Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 23,677,1981 |
| ACUTE TOXICITY DATA | TDLo - Lowest published toxic dose | Oral | Rodent - mouse | 35 mg/kg,female 6 day(s) after conception | Reproductive-Fertility-other measures of fertility | Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 16,1285,1978 |
p-Coumaric acid Use and Manufacturing
p-Coumaric Acid is the hydroxy derivative of Cinnamic Acid with antioxidant properties. p-Coumaric acid is a is a major component of lignocellulose. Studies suggest that p-Coumaric Acid may reduce the risk of cancer by reducing the formation of carcinogenic nitrosamines.
Analysis Methods
| Name | Column Shape | Active Phase(℃) | Retention index | Temperature Control | Method | Comments | Reference |
|---|---|---|---|---|---|---|---|
| Normal alkane RI, non-polar column, isothermal | Packed | Apieson L | 1635. | 140. | isothermal | Nitrogen, Chromosorb W HMDS (60-80 mesh); Column length: 1.8 m | Hedin, P.A.Minyard, J.P.Thompson, A.C.Chromatographic and spectral analysis of phenolic acids and related compoundsJ. Chromatogr.1967, 30, 43-53. |
| Normal alkane RI, non-polar column, isothermal | Capillary | DB-1 | 1631. | custom temperature program | 30. m/0.25 mm/0.25 μm; Program: not specified | Marlatt, C.Ho, C.-T.Chien, M.Studies of aroma constituents bound as glycosides in tomatoJ. Agric. Food Chem.1992, 40, 2, 249-252. |
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