4-Aminonicotinic acid
-
4-Aminonicotinic acid
structure -
-
CAS No:
7418-65-7
-
Formula:
C6H6N2O2
-
Chemical Name:
4-Aminonicotinic acid
-
Synonyms:
3-Pyridinecarboxylic acid,4-amino-;Nicotinic acid,4-amino-;4-Amino-3-pyridinecarboxylic acid;4-Aminonicotinic acid;4-Aminopyridine-3-carboxylic acid;NSC 266130
- Categories:
-
CAS No:
Description
Light yellow Cryst
4-aminonicotinic acid is an aminonicotinic acid in which the amino group is situated at position 4 of the pyridine ring. It has a role as a metabolite. It is an aromatic amine, an aminopyridine and an aminonicotinic acid. It derives from a 4-aminopyridine and a nicotinic acid.
Characteristics
76.2
0.2
Cream to yellow Powder
1.4±0.1 g/cm3
328 °C (decomp)
395.834ºC at 760 mmHg
193.2±23.7 °C
1.649
soluble in aqueous acid and base.
Safety Information
IRRITANT
NONH for all modes of transport
3
36/37/38
26-37/39
Xi
Irritant
P261-P305 + P351 + P338
H315-H319-H335
|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 44 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
4-Aminonicotinic acid Use and Manufacturing
To a stirred solution of methyl 4-aminopyridine-3-carboxylate (2 g, 13.15 mmol) in EtOHwater(120 mL, 1:1), LiOH·H20 (1.21 g, 28.80 mmol) was added at RT and heated at 80 °Cfor 2 h (TLC indicated complete consumption of starting material). The volatiles wereremoved under reduced pressure to give the crude compound which was dissolved in water(30 mL), washed with EtOAc (2 x 25 mL) to remove the non-polar impurities. The aqueouslayer was acidified with 1 N HCl till pH= 1, and extracted with EtOAc (2 x 10 mL). Thecombined organic extracts were concentrated under reduced pressure to give the cruderesidue which was crystallized from MeOH (20 mL) to obtain 4-aminopyridine-3-carboxylicacid (1 g, 55percent) as an off-white solid.LCMS (ESI+): m/z: 139.31 [M+Ht.A solution of 4-chloropyridine-3-carboxylic acid (15 g, 0.095 mol) in aqueous NH
Computed Properties
Molecular Weight:138.12
XLogP3:0.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:138.042927438
Monoisotopic Mass:138.042927438
Topological Polar Surface Area:76.2
Heavy Atom Count:10
Complexity:138
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Recommended Suppliers of 4-Aminonicotinic acid
-
![China]()
CN
5 YRS
Business licensedTrader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives -
![China]()
CN
5 YRS
Business licensed Certified factoryManufactory Supplier of fine chemicals,pharmaceutical materials -
![China]()
CN
5 YRS
Business licensedTrader Supplier of PVC resin,pvc paste resin,melamineInquiryCAS No.: 7418-65-7Grade: Industrial GradeContent: 99% -
![China]()
CN
3 YRS
Business licensed Certified factoryManufactory Supplier of Dyes,Textile agent,Medical intermediate,API,Pigments,Basic ChemicalsInquiryCAS No.: 7418-65-7Grade: pharmaceutical gradeContent: 98%
Learn More Other Chemicals
-
3,5-DIBROMO-2-[[[(3,5-DINITROBENZOYL)AMINO]THIOXOMETHYL]AMINO]-BENZOIC ACID
535965-38-9
-
3,5-DIBROMO-2-[[[[(2-CHLOROPHENOXY)ACETYL]AMINO]THIOXOMETHYL]AMINO]-BENZOIC ACID
532386-89-3
-
3,5-DIBROMO-2-[[[(4-METHYL-3-NITROBENZOYL)AMINO]THIOXOMETHYL]AMINO]-BENZOIC ACID
532943-48-9
-
3,5-DIBROMO-2-[[[[3-(2-FURANYL)-1-OXO-2-PROPENYL]AMINO]THIOXOMETHYL]AMINO]-BENZOIC ACID Formula
586392-09-8
-
3,5-DIBROMO-2-[[[[(2-METHYLPHENOXY)ACETYL]AMINO]THIOXOMETHYL]AMINO]-BENZOIC ACID Formula
531548-30-8
-
2-(1,8-dibromo-16,18-dioxo-17-azapentacyclo[6.6.5.0~2,7~.0~9,14~.0~15,19~]nonadeca-2,4,6,9,11,13-hexaen-17-yl)benzoic acid Formula
333340-54-8
-
3,5-DIBROMO-2-[[[[3-(PHENOXYMETHYL)BENZOYL]AMINO]THIOXOMETHYL]AMINO]-BENZOIC ACID Structure
586393-79-5
-
3,5-DIBROMO-2-[[[(4-CHLOROBENZOYL)AMINO]THIOXOMETHYL]AMINO]-BENZOIC ACID Structure
531530-32-2
-
What is 2-Cyclopentyl-3-(2,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-oxo-4-isoquinolinecarboxylic acid
400073-92-9
-
What is 9-Octadecenoic acid (9Z)-, compd. with N,N-dimethylcyclohexanamine (1:1)
65122-23-8