Cinchonan-9-ol, 6′-methoxy-, hydrochloride (1:?), (8α,9R)-
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Cinchonan-9-ol, 6′-methoxy-, hydrochloride (1:?), (8α,9R)-
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CAS No:
7549-43-1
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Formula:
C20H24N2O2.xClH
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Chemical Name:
Cinchonan-9-ol, 6′-methoxy-, hydrochloride (1:?), (8α,9R)-
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Synonyms:
Cinchonan-9-ol,6′-methoxy-,hydrochloride (1:?),(8α,9R)-;Quinine,hydrochloride;Cinchonan-9-ol,6′-methoxy-,hydrochloride,(8α,9R)-
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CAS No:
Description
An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It was used commonly and as a bitter and flavoring agent, and is still useful for the treatment of babesiosis. Quinine is also useful in some muscular disorders, especially nocturnal leg cramps and myotonia congenita, because of its direct effects on muscle membrane and sodium channels. The mechanisms of its antimalarial effects are not well understood.
Cinchonan-9-ol, 6′-methoxy-, hydrochloride (1:?), (8α,9R)- Basic Attributes
360.87800
360.16000
231-437-7
7CS0WNO31M
DTXSID7044213
Safety Information
VA7700000
|Warning|H302 (99.93%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P322, P330, P363, and P501|Aggregated GHS information provided by 1408 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|Danger|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P272, P280, P285, P301+P312, P302+P352, P304+P312, P304+P340, P304+P341, P312, P321, P330, P333+P313, P342+P311, P363, and P501|Aggregated GHS information provided by 8 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H302: Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P272, P280, P301+P312, P302+P352, P321, P330, P333+P313, P363, and P501
Drug Information
Agents used in the treatment of malaria. They are usually classified on the basis of their action against plasmodia at different stages in their life cycle in the human. (From AMA, Drug Evaluations Annual, 1992, p1585) (See all compounds classified as Antimalarials.)|A heterogeneous group of drugs used to produce muscle relaxation, excepting the neuromuscular blocking agents. They have their primary clinical and therapeutic uses in the treatment of muscle spasm and immobility associated with strains, sprains, and injuries of the back and, to a lesser degree, injuries to the neck. They have been used also for the treatment of a variety of clinical conditions that have in common only the presence of skeletal muscle hyperactivity, for example, the muscle spasms that can occur in MULTIPLE SCLEROSIS. (From Smith and Reynard, Textbook of Pharmacology, 1991, p358) (See all compounds classified as Muscle Relaxants, Central.)|A subclass of analgesic agents that typically do not bind to OPIOID RECEPTORS and are not addictive. Many non-narcotic analgesics are offered as NONPRESCRIPTION DRUGS. (See all compounds classified as Analgesics, Non-Narcotic.)
Biquinate
Cinchonan-9-ol, 6′-methoxy-, hydrochloride (1:?), (8α,9R)- Use and Manufacturing
ANTI MALARIALS
Cinchonan-9-ol, 6'-methoxy-, hydrochloride (1:1), (8.alpha.,9R)-: ACTIVE|Cinchonan-9-ol, 6'-methoxy-, hydrochloride (1:?), (8.alpha.,9R)-: INACTIVE
Food additives -> Flavoring Agents|Flavouring Agent -> FLAVOURING_AGENT; -> JECFA Functional Classes
Flavoring Agents|Flavouring Agent -> FLAVOURING_AGENT;
Computed Properties
Molecular Weight:360.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:360.1604557
Monoisotopic Mass:360.1604557
Topological Polar Surface Area:45.6
Heavy Atom Count:25
Complexity:457
Defined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
Recommended Suppliers of Cinchonan-9-ol, 6′-methoxy-, hydrochloride (1:?), (8α,9R)-
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CN
5 YRS
Business licensedTrader Supplier of API,nutrition supplements,plant extract,peptide,HCGInquiryCAS No.: 7549-43-1Grade: Pharmaceutical GradeContent: 99%
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Cinchonan-9-ol, 6′-methoxy-, hydrochloride (1:?), (8α,9R)-
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