Sodium arsenate (Na2HAsO4)

185.91

141.92500

231-902-4

ANU034TUJ4

1208

1685

DTXSID8032047

Powder|Clear colorless crystals

2842909017

77.76000

-2.17060

COLOURLESS-TO-WHITE CRYSTALS OR POWDER.

1.87 g/cm³

57 °C

g/100g solution H2O: 5.59 (0.1°C), 29.33 (25°C), 66.5 (98.5°C); solid phase, Na2HAsO4 ·12H2O (0.1°C), Na2HAsO4 ·7H2O (25°C), Na2HAsO4(98.5°C) [KRU93]; slightly soluble alcohol [MER06]

It is important to keep stored organic arsenic compounds in a cool, dry, well-ventilated area in tightly sealed containers and with proper labels and identifi cation. The storage containers of organic arsenic compounds should be protected from physical damage and stored separately from oxidizers such as perchlorates, peroxides, permanganates, chlorates, or nitrates, and strong acids such as hydrochloric, sulfuric, or nitric acid. Further, specifi c organic arsenic compounds must have separate s

Abdominal cavity-rat LDL0: 34.72 mg/kg

Non-combustible substance; emits toxic arsenide vapors when exposed to heat

Mild alkaline taste

Crystals; odorless; MP: 57 °C; density: 1.87; sol 1:3 parts water; sol in glycerol; slightly sol in alcohol; aq soln alkaline to litmus; loses 5 H2O @ 50 °C; anhyd @ 100 °C; @ 150 °C or higher converted to pyroarsenate. /Heptahydrate/

II

6.1(a)

1685

45-23/25-50/53

53-45-60-61

CG0875000

T, N

Treasury is ventilated, low temperature and dry; stored separately from alkali, acid and food additives

EFFLORESCES IN WARM AIR /SODIUM ARSENATE HEPTAHYDRATE/

P201, P202, P260, P261, P264, P270, P271, P280, P281, P301+P310, P302+P352, P304+P340, P308+P313, P311, P312, P314, P321, P322, P330, P363, P403+P233, P405, P501

H301

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.|Recycling: Sodium is precipitated as hydroxides by using an excess of lime water, and the arsenic is precipitated as calcium arsenate and calcium arsenite. This "arsenic sludge" is recycled, on the one hand, in order not to lose the valuable metals, and on the other, in order to reduce the problem of arsenic sludge disposal. The following storage possibilities are available today for arsenic residues that cannot be recycled immediately or at all: 1) special dumps sealed against the penetration of ground water, surface water and rain water; 2) galleries in abandoned salt mines; 3) concrete silos. Recommendable methods: Precipitation, solidification /hazardous waste/, landfill. Not recommendable methods: Thermal destruction, discharge to sewer.|Chemical Treatability of Arsenic; Concentration Process: Chemical Precipitation; Chemical Classification: Metal; Scale of Study: Pilot Scale; Type of Wastewater Used: Domestic Wastewater + Pure Compound; Results of Study: 5ppm @ 4gpm @ pH= 7.0. Iron system-90% reduction; low lime system-80% reduction; high lime system-76% reduction; (3 coagulant systems were used; Iron system used 45 ppm as Fe of Fe2(SO4)3 @ pH= 6.0. Low lime system used 20 ppm Fe of Fe2(SO4)3 and 260 ppm of CaO @ pH= 10.0. High lime system used 600 ppm of CaO @ pH= 11.5. Chemical coagulation was followed by multimedia filtration). /Arsenic cmpd/|Chemical Treatability of Arsenic; Concentration Process: Chemical Precipitation; Chemical Classification: Metal; Scale of Study: Full Scale Continuous Flow; Type of Wastewater Used: Domestic Wastewater; Results of Study: Effluent character (ppb): 2.5, 56% reduction with lime; 3.3, 24% reduction with lime; (lime dose of 350-400 ppm as calcium oxide @ pH= 11.3). /Arsenic cmpd/|Storage: To convert the gas-cleaning residues obtained during the metallurgical processing of arsenic-containing ores into a portable and less water-soluble form, the metals are precipitated as hydroxides by using an excess of lime water and the arsenic is precipitated as calcium arsenate and calcium arsenite. This "arsenic sludge" is recycled, on the one hand, in order not to lose the valuable metals, and on the other, in order to reduce the problem of arsenic sludge disposal. The following storage possibilities are available today for arsenic residues that cannot be recycled immediately or at all: special dumps sealed against the penetration of ground water, surface water and rain water; galleries in abandoned salt mines; concrete silos. In any case the sludge must be dewatered beforehand until it is compact. Recommendable methods: Precipitation, solidification, landfill. Not recommendable: Thermal destruction, discharge to sewer. Peer-review: Soluble arsenic cmpd should be converted to the insoluble sulfide before solidification. (Peer-review conclusions of an IRPTC expert consultation (May 1985)) /Arsenates and arsenites/

... WHEN WATER SOLN OF ARSENICALS ARE IN CONTACT WITH ACTIVE METALS SUCH AS ARSENIC, IRON, ALUMINUM, ZINC, ... HIGHLY TOXIC FUMES OF ARSENIC /INCLUDING ARSINE ARE RELEASED/. /ARSENIC CMPD/|Strong oxidizers, bromide azide [Note: Hydrogen gas can react with inorganic arsenic to form the highly toxic gas arsine.] /Arsenic (inorganic compounds, as As)/

U.S. Environmental Protection Agency's Integrated Risk Information System (IRIS) on Arsenic, inorganic (7440-38-2).[Available from the Substance File List as of March 15, 2000: http://www.epa.gov/iris/subst/index.html]|USEPA; Ambient Water Quality Criteria Doc: Arsenic p.A-2 (1980) EPA 440/5-80-021|WHO; Environmental Health Criteria Document No. 224: Arsenic and arsenic compounds. EHC are designed for scientists and administrators responsible for the establishment of safety standards and regulations and provide basic scientific risk evaluations of a wide range of chemicals and groups of chemicals.[Available from, as of July 28, 2009: http://www.inchem.org/pages/ehc.html]|IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work). Volume 84 (2004). Some Drinking-water Disinfectants and Contaminants, including Arsenic.[Available from, as of July 22, 2009: http://monographs.iarc.fr/ENG/Monographs/vol84/volume84.pdf]|National Toxicology Program. Eleventh Report on Carcinogens (2005). The Report on Carcinogens is an informational scientific and public health document that identifies and discusses substances (including agents, mixtures, or exposure circumstances) that may pose a carcinogenic hazard to human health. Inorganic Arsenic Compounds are listed as known to be human carcinogens. /Arsenic Compounds, Inorganic/[Available from, as of July 31, 2009: http://ntp.niehs.nih.gov/ntp/roc/eleventh/profiles/s015arse.pdf]

Not combustible. Gives off irritating or toxic fumes (or gases) in a fire.

|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P201, P202, P261, P264, P270, P271, P273, P281, P301+P310, P304+P340, P308+P313, P311, P321, P330, P391, P403+P233, P405, and P501|Aggregated GHS information provided by 3 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H301: Toxic if swallowed [Danger Acute toxicity, oral]|P201, P202, P260, P261, P264, P270, P271, P280, P281, P301+P310, P302+P352, P304+P340, P308+P313, P311, P312, P314, P321, P322, P330, P363, P403+P233, P405, and P501|H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]|P201, P202, P260, P264, P270, P280, P281, P305+P351+P338, P307+P311, P308+P313, P314, P321, P337+P313, P405, and P501|H315: Causes skin irritation [Warning Skin corrosion/irritation]|P201, P202, P260, P264, P270, P280, P281, P302+P352, P305+P351+P338, P307+P311, P308+P313, P314, P321, P332+P313, P337+P313, P362, P405, and P501

Workers should be supplied with suitable protective clothing, protective boots and when there is a risk that the exposure limit for airborne arsenic will be exceeded, respiratory protective equipment. /Arsenic cmpd/|Where there is occupational exposure to inorganic arsenic compounds, protective clothing shall be provided by the employers. This may include underwear, gloves, coveralls, and a hood over the head and neck. /Inorganic arsenic/|Wear appropriate personal protective clothing to prevent skin contact. /Arsenic (inorganic cmpd, as As)/|Wear appropriate eye protection to prevent eye contact. /Arsenic (inorganic cmpd, as As)/|For more Personal Protective Equipment (PPE) (Complete) data for SODIUM ARSENATE (6 total), please visit the HSDB record page.

If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use foam, dry chemical, or carbon dioxide. /Arsenical cmpd, liquid, NOS/|If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use foam, dry chemical, or carbon dioxide. /Arsenical cmpd, solid, NOS/|Personnel protection: ... Wear positive pressure self-contained breathing apparatus when fighting fires involving this material. /Arsenical cmpd, solid, NOS/

Prompt cleanup and removal are necessary. Control runoff and isolate discharged material for proper disposal.|Both arsenate and arsenite can be removed from the water column by co-precipitation or adsorption onto iron oxides. Arsenate species can also be removed by adsorption onto aluminum hydroxide and clays, while arsenite is readily adsorbed onto metal sulfides. /Arsenate and arsenite/|Floors and other accessible surfaces contaminated with inorganic arsenic may not be cleaned by the use of compressed air, and shoveling and brushing may be used only where vacuuming or other relevant methods have been tried and found not to be effective. /Inorganic arsenic compounds/

WELL VENTILATED & ALL POISONOUS FUME ... CONDENSED & DUST CONTENT REMOVED. ... EXHAUST HOODS ... WORKTABLES ... EQUIPPED WITH DOWN-DRAUGHT ... VENTILATION. /ARSENIC CMPD/|IN ... /FACTORIES/ WITH ARSENIC HAZARD, FLOORS ... SHOULD BE ... IMPERMEABLE ... TO PREVENT ABSORPTION & ... FLUSHED DOWN FREQUENTLY WITH WATER. /ARSENIC CMPD/|Lockers should be provided with separate compartments for work & personal clothes, & adjacent sanitary facilities of a high standard should be made available. Smoking, eating, & drinking at the workplace should not be allowed. /Arsenic & cmpd/|Employees exposed to arsenic shall wash their hands and exposed skin before eating or smoking during the work shift. No food shall be permitted in areas where arsenic is handled, processed, or stored. Employees shall not smoke in areas where arsenic is handled, processed, or stored. /Inorganic arsenic/|For more Preventive Measures (Complete) data for SODIUM ARSENATE (17 total), please visit the HSDB record page.

/GUIDE 151: SUBSTANCES - TOXIC (NON-COMBUSTIBLE)/ Health: Highly toxic, may be fatal if inhaled, swallowed or absorbed through skin. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.|/GUIDE 151: SUBSTANCES - TOXIC (NON-COMBUSTIBLE)/ Fire or Explosion: Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Containers may explode when heated. Runoff may pollute waterways.|/GUIDE 151: SUBSTANCES - TOXIC (NON-COMBUSTIBLE)/ Public Safety: CALL Emergency Response Telephone Number ... . As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at lease 25 meters (75 feet) for solids. Keep unauthorized personnel away. Stay upwind. Keep out of low areas.|/GUIDE 151: SUBSTANCES - TOXIC (NON-COMBUSTIBLE)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible.|For more DOT Emergency Guidelines (Complete) data for SODIUM ARSENATE (8 total), please visit the HSDB record page.

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./|The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.|The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

/ONE OF/ ... PRIMARY IRRITANTS ... .|ARSENICAL DUSTS ... ARE IRRITATING TO UPPER RESP TRACT & EYES. CONJUNCTIVITIS PRODUCED BY ... THESE SUBSTANCES ARE CHARACTERIZED BY ITCHING, BURNING, & WATERING OF EYES. ... /INORGANIC ARSENIC DUSTS/

8 hr Time-Weighted avg: 10 ug/cu m./Arsenic, inorganic cmpd (as As)/|Permissible Exposure Limit: Table Z-1 8-Hr Time Weighted Avg: 0.5 mg/cu m. /Arsenic, organic cmpd (as As)/

5 mg/cu m (as As); NIOSH considers arsenic (inorganic cmpd, as As) to be a potential occupational carcinogen. /Arsenic (inorganic cmpd, as As)/|Recommended Exposure Limit: 15 Ceiling Limit: (0.002 mg/cu m). /Arsenic (inorganic cmpd, as As)/|NIOSH usually recommends that occupational exposures to carcinogens be limited to the lowest feasible concentration. /Arsenic (inorganic compounds, as As)/

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Vacuum with specialist equipment or carefully sweep into containers. Carefully collect remainder. Then store and dispose of according to local regulations.

Separated from acids and food and feedstuffs. Well closed. Dry. Do NOT store or transport in containers made from metal. Store in an area without drain or sewer access.

A harmful concentration of airborne particles can be reached quickly when dispersed, especially if powdered.

The substance is irritating to the eyes and respiratory tract. Ingestion could cause effects on the gastrointestinal tract. This may result in severe gastroenteritis, loss of fluids and electrolytes, cardiac disorders and shock. Exposure far above the OEL could cause death. The effects may be delayed. Medical observation is indicated.

The substance may have effects on the skin, mucous membranes, peripheral nervous system, bone marrow and liver. This may result in pigmentation disorders, hyperkeratosis, perforation of the nasal septum, neuropathy, anaemia and liver impairment. This substance is carcinogenic to humans. Animal tests show that this substance possibly causes toxicity to human reproduction or development.

PREVENT DISPERSION OF DUST! AVOID ALL CONTACT!

Use closed system, ventilation or breathing protection.

Protective gloves. Protective clothing.

Wear face shield or eye protection in combination with breathing protection.

Listed as a hazardous air pollutant (HAP) generally known or suspected to cause serious health problems. The Clean Air Act, as amended in 1990, directs EPA to set standards requiring major sources to sharply reduce routine emissions of toxic pollutants. EPA is required to establish and phase in specific performance based standards for all air emission sources that emit one or more of the listed pollutants. Sodium arsenate is included on this list.|(a) The owner or operator of an existing glass melting furnace subject to the provisions of this subpart shall comply with either paragraph (a)(1) or (a)(2) of this section ... (1) Uncontrolled total arsenic emissions from the glass melting furnace shall be less than 2.5 Mg (2.7 ton) per year, or ... (2) Total arsenic emissions from glass melting furnace shall be conveyed to a control device and reduced by at least 85%. /Total arsenic/|(b) The owner or operator of a new or modified glass melting furnace subject to the provisions of this subpart shall comply with either paragraph (b)(1) or (b)(2) of this section ... (1) Uncontrolled total arsenic emissions from the glass melting furnace shall be less than 0.4 Mg (0.44 ton) per year, or ... (2) Total arsenic emissions from glass melting furnace shall be conveyed to a control device and reduced by at least 85%. /Total arsenic/|The owner or operator of each copper converter subject to the provisions of this subpart shall reduce inorganic arsenic emissions to the atmosphere by meeting the following design, equipment, work practice, and operational requirements: (1) Install, operate, and maintain a secondary hood system on each copper converter. Each secondary hood system shall consist of a hood enclosure, air curtain fan(s), exhaust system fan(s), and ductwork that conveys the captured emission to a control device ... (2) Optimize the capture of secondary inorganic arsenic emission by operating the copper converter and secondary hood systems at all times ... . /Inorganic arsenic/|For more Atmospheric Standards (Complete) data for SODIUM ARSENATE (6 total), please visit the HSDB record page.

D004; A waste containing arsenic may or may not be characterized as a hazardous waste following testing by the Toxicity Characteristic Leaching Procedure as prescribed by the Resource Conservation and Recovery Act (RCRA) regulations. /Arsenic/

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 1 lb or 0.454 kg. The toll free number of the NRC is (800) 424-8802; In the Washington D.C. metropolitan area (202) 426-2675. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).

most toxic

The teratogenicity of sodium dichromate (2 mg chromium/kg), sodium arsenate (5 mg arsenic/kg) & copper sulfate (2 mg copper/kg) in female Wistar rats was studied following the ip admin of the test cmpds separately & in their various combinations on gestation day 8. The test cmpds administered separately were non-fetotoxic & either non- or weakly teratogenic, whereas arsenate/copper(2+) was both weakly fetotoxic & teratogenic. Dichromate/arsenate & dichromate/arsenate/copper(2+) caused a marked decr in mean fetal wt & an incr incidence of fetal resorption & abnormality formation.|Female Swiss mice were exposed to sodium arsenite or sodium arsenate in drinking water for 15 wk at concns ranging from 0-100 ug/ml arsenic content. After 3 wk of the 15 wk exposure period, the mice were administered urethane (1.5 mg/g) ip. Pulmonary adenoma formation was evaluated 12 wk later. Both forms of arsenic reduced the size & number of pulmonary adenomas observed/mouse. In addition, urethane induced sleeping times which reflect the rate of urethane metab or excretion remained unchanged. This suggests that arsenic exposure does not alter urethane excretion & is not a factor influencing subsequent adenoma formation at these levels of exposure.|BAL subcutaneously injected in mice (50 mg/kg bw, reduced the teratogenic action of simultaneous ip injections of sodium arsenate at a level of 16 mg As/kg bw ... .|Low doses of sodium dichromate (5 mg/kg), sodium arsenate (25 mg/kg), and copper sulfate (5.9 mg/kg) were administered intraperitoneally in all possible combinations to groups of 6 rats each. With sodium arsenate alone, growth rate did not differ from that of the control; kidney weight was significantly higher (0.94% of total body weight vs 0.87% in controls) and serum creatinine was significantly higher (94.8 + or - 16.3 vs 43.8 + or - 3.9 umol/l in controls). /In sodium arsenate treated animals/, growth rate, relative kidney weight, and serum creatinine levels were similar to those of the controls. In the animals treated with arsenate and copper sulfate, body weight gain followed the course of that with copper alone; kidney weight was the same as in the control group; and serum creatinine was 65.3 + or - 5.1 umol/l. In the group treated with all three chemicals the growth rate and serum creatinine concentration were similar to those of the control group, whereas the kidney weight was 0.92% of total body weight. High doses of each compound were administered with the previously mentioned low doses of the other compounds in all combinations. High doses were 35 mg/kg for sodium dichromate, 9 mg/kg for sodium arsenate, and 23.5 mg/kg for copper sulfate. Whereas no deaths occurred during the low dose study ... . Animals given arsenate alone lost a slight amount of weight and the subsequent growth rate (3.4 + or - 0.7 g/day) was significantly less than that in the controls (5.4 + or - 0.1 g/day). Relative kidney weight was 0.96% of total body weight, compared with 0.87% in the controls. Serum creatinine levels were not significantly elevated. The coadministration of high dose arsenate with low doses of chromium and/or copper had no significant effect on relative kidney weight or serum creatinine concentration as compared with the high dose of arsenate alone.

MLD RATS IP 50 MG/KG /SODIUM ARSENATE HEPTAHYDRATE/

ARSENITES OF ALKALI METALS ARE SLOWLY CONVERTED IN SOLN TO ARSENATES BY ATMOSPHERIC OXYGEN.

MEDICINE: FORMERLY AS "ANTIMALARIAL; DERMATOLOGIC"|MEDICATION (VET): Has been used in parasitism (internally and externally), also for nonparasitic skin and blood diseases, in rheumatism, asthma and heaves, and as an alternative.

Pesticides designed to control insects that are harmful to man. The insects may be directly harmful, as those acting as disease vectors, or indirectly harmful, as destroyers of crops, food products, or textile fabrics. (See all compounds classified as Insecticides.)

Arsenic (as disodium arsenate) binds to thiol groups of the enzyme DNA polymerease, thus inhibiting DNA synthesis; the authors concluded that it interfered with DNA repair of damage induced by UV irradiation in human epidermal grafts ... .|Disodium arsenate alters the metabolism of nucleosides and their derivatives in human lymphocytes cultered in vitro ... and reduced the incorporation of labelled nucleosides into both RNA and DNA in cultured human peripheral lymphocytes ... .

Fresh air, rest. Refer for medical attention.

Remove contaminated clothes. Rinse and then wash skin with water and soap. Seek medical attention if you feel unwell.

Rinse with plenty of water for several minutes (remove contact lenses if easily possible). Refer for medical attention.

/HEPTAHYDRATE/ POISONOUS, BUT LESS SO THAN THE ARSENITE.|... AMONG WORKERS IN A FACTORY MANUFACTURING A SOLN OF SODIUM ARSENATE, ... RADIOGRAPHIC EXAMINATION DID NOT REVEAL ANY CASE OF BRONCHOGENIC CARCINOMA.|The ability of arsenic, nickel, & chromium compounds to induce transformation in cultured primary human diploid foreskin cells was studied. All nickel cmpds tested, lead chromate, potassium dichromate, chromic acid, dibasic sodium arsenate, NaAsO2 & N-methyl-N'nitro-N-nitrosoguanidine (MNNG) caused significant (p= 0.001) dose dependent inductions of anchorage independent colonies. ... Anchorage independent cell strains derived from metal salt treated cells were not resistant to the cytotoxicity of metal salts, indicating metal salts induced rather than selected for anchorage independence. ...|Sodium arsenate, at concn ranging from 6X10-9M to 6X10-8M, caused a small number of chromosomal aberrations (chromatid breaks, chromatid exchanges) in cultured human peripheral lymphocytes ... .

arsenic acid (H3AsO4), sodium salt (1:3)

The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.

Cough. Sore throat.

Redness. Pain.

By early 1900's,...sodium arsenate /was used on monocotyledenous crops/

... salt of commerce ... about 99% pure.|Grade: Pure crystals, CP /chemically pure: a grade designation signifying a minimum of impurities, but not 100% purity/, technical (60% arsenic pentoxide).

Arsenic acid (H3AsO4), sodium salt (1:2): ACTIVE