2-(4-Aminophenyl)-5-aminobenzimidazole
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2-(4-Aminophenyl)-5-aminobenzimidazole
structure -
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CAS No:
7621-86-5
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Formula:
C13H12N4
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Chemical Name:
2-(4-Aminophenyl)-5-aminobenzimidazole
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Synonyms:
1H-Benzimidazol-6-amine,2-(4-aminophenyl)-;Benzimidazole,5-amino-2-(p-aminophenyl)-;1H-Benzimidazol-5-amine,2-(4-aminophenyl)-;Benzimidazole,5(or 6)-amino-2-(p-aminophenyl)-;2-(4-Aminophenyl)-1H-benzimidazol-6-amine;5-Amino-2-(p-aminophenyl)benzimidazole;5,4′-Diamino-2-phenylbenzimidazole;2-(4-Aminophenyl)-5-aminobenzimidazole;5-Amino-2-(4-aminophenyl)benzimidazole;5(6)-Amino-2-(p-aminophenyl)benzimidazole;5(6)-Amino-2-(4′-aminophenyl)benzimidazole;NSC 408148;6,4′-Diamino-2-phenylbenzimidazole;5-Amino-2-(4-aminobenzene)benzimidazole;5-Amino-2-(4-aminophenyl)-1H-benzimidazole;BIA;2-(4-Aminophenyl)-1H-benzimidazol-5-amine;2-(4-Aminophenyl)-1H-benzimidazole-5-amine;5-Amino-2-(4-aminophenyl)benzylimidazole;2-(4-Aminophenyl)-1H-1,3-benzodiazol-6-amine;2-(4-Amino-phenyl)-1H-benzoimidazol-5-ylamine;2-(4-Aminophenyl)-1H-1,3-benzodiazol-5-amine;2-(4-Aminophenyl)-3H-benzimidazol-5-amine;2-(4-Aminophenyl)-1H-benzo[d]imidazol-5-amine;67294-77-3
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CAS No:
2-(4-Aminophenyl)-5-aminobenzimidazole Basic Attributes
224.26
224.26
231-538-6
408148
DTXSID0064755
2933990090
Characteristics
80.7
1.9
1.359 g/cm3
>320 °C
545.5°C at 760 mmHg
317.6ºC
1.787
Oral-rat LD50: 5000 mg/kg; Oral-Mouse LD50: 5500 mg/kg
Flammable; burning produces toxic nitrogen oxide fumes
Safety Information
Ⅲ
2811
6.1
DD5421200
Warehouse ventilated, low temperature and dry
P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P322, P330, P363, P501
H302
|Warning|H302 (94.29%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P322, P330, P363, and P501|Aggregated GHS information provided by 36 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
2-(4-Aminophenyl)-5-aminobenzimidazole Use and Manufacturing
At room temperature, To a 100 mL ml single-necked flask was added 2-(4-nitrophenyl)-5-nitrobenzimidazole (2.84 g, 0.01 mol) and 50 mL of water, Adding phosphoric acid, Adjust the pH below 1.Add sodium sulfide solid (3.9 g, 0.05 mol), Warming up to 100 C, Continuous reaction for 12 h. After being cooled to room temperature, it was filtered, and the filtrate was neutralized to a pH of 7 by adding a sodium carbonate aqueous solution having a concentration of 25% by weight, and the product was precipitated from the reaction system, filtered, washed with water several times, and dried to obtain 2.15 g of the product 2-(4). -aminobenzene)-5-aminobenzimidazole (yield 96%, purity (HPLC) >99.9%), Possible diamines of the general formula (II) where n=2 are, for example: ... 4, 4'-diamino-benzanilide, 2-(4-aminophenyl)-5-amino-2H-benzotriazole, 3, 3'-dichlorobenzidine, 4, 4'-diaminobenzophenone, 2-(4-aminophenyl)-5-amino-benzimidazole, 4, 4'-diamino-N, N'-diphenylurea, 4, 4'-diaminodiphenylamine, 1, 2-bis-(4'-aminophenyl)-ethane, ... Preparation of the DAPBI 242 parts of N1 -(4'-aminobenzoyl)-1, 2, 4-triamino-benzene are dissolved in 500 parts of a 20 Be solution of hydrochloric acid and 1000 parts of water, and the mixture is then heated at 100 C. for 3 hours. 1000 parts of ice and then 500 parts of a 20 Be solution of ammonia are added. The precipitate is filtered off and dried. 210 parts of 2-(4'-amino-phenyl)-5-aminobenzimidazole are thus obtained. After recrystallisation from ethanol, then heating at 170 C for an hour, the product melts at 235 C., conforming to the information in the literature. Analysis C13 H12 N4 Molecular weight 224.26 Calculated: C, 69.62%; H, 5, 40%; N, 24.98%. Found: C, 68.85%; H, 5.48%; N, 24.75%.13.44 g (ie 60 mmol) of General procedure: Example 4 This example demonstrates the synthesis of
1H-Benzimidazol-6-amine, 2-(4-aminophenyl)-: ACTIVE
Computed Properties
Molecular Weight:224.26
XLogP3:1.9
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:224.106196400
Monoisotopic Mass:224.106196400
Topological Polar Surface Area:80.7
Heavy Atom Count:17
Complexity:262
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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2-(4-Aminophenyl)-5-aminobenzimidazole
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