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Ethyl N-[(4-methylphenyl)sulfonyl]carbamate

Ethyl N-[(4-methylphenyl)sulfonyl]carbamate structure

CAS No:
5577-13-9
Formula:
C10H13NO4S
Chemical Name:
Ethyl N-[(4-methylphenyl)sulfonyl]carbamate
Synonyms:
Carbamic acid,N-[(4-methylphenyl)sulfonyl]-,ethyl ester;Carbamic acid,(p-tolylsulfonyl)-,ethyl ester;Carbamic acid,[(4-methylphenyl)sulfonyl]-,ethyl ester;Ethyl N-[(4-methylphenyl)sulfonyl]carbamate;Ethyl p-tosylcarbamate;Ethyl (p-toluenesulfonyl)carbamate;Ethyl (p-tolylsulfonyl)carbamate;Tosylurethane;Ethyl N-(4-methylbenzenesulfonyl)carbamate;N-Tosylurethane;Ethyl N-tosylcarbamate;Ethyl tosylcarbamate

Description

Ethyl tosylcarbamate is an intermediate in the synthesis of Gliclazide (G409877)[1][2]. Gliclazide is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM[3].

Ethyl N-[(4-methylphenyl)sulfonyl]carbamate Basic Attributes

Molecular Weight：

243.28

Exact Mass：

243.28

EC Number：

226-952-9

HScode：

2935009090

Characteristics

PSA：

80.8

XLogP3：

1.9

Density：

1.3±0.1 g/cm3

Melting Point：

87-88 °C

Refractive Index：

1.530

Safety Information

Precautionary statement(s)：

P261, P264, P270, P271, P273, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (40%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P273, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 5 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Ethyl N-[(4-methylphenyl)sulfonyl]carbamate Use and Manufacturing

General procedure: The 4-substituted methyl (phenylsulfonyl)carbamate was dissolved in the chosen alcohol (2 mL) in a microwave vial, which was closed using an aluminum open-top seal with PTFE-faced septum. The reaction mixture was heated under microwave irradiation at 100-120

Computed Properties

Molecular Weight:243.28
XLogP3:1.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:243.05652907
Monoisotopic Mass:243.05652907
Topological Polar Surface Area:80.8
Heavy Atom Count:16
Complexity:325
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Guide of Ethyl N-[(4-methylphenyl)sulfonyl]carbamate

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Computed Properties
Learn More Other Chemicals

Ethyl N-[(4-methylphenyl)sulfonyl]carbamate

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