Brimonidine tartrate
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Brimonidine tartrate
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CAS No:
70359-46-5
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Formula:
C11H10BrN5.C4H6O6
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Chemical Name:
Brimonidine tartrate
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Synonyms:
6-Quinoxalinamine,5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-,(2R,3R)-2,3-dihydroxybutanedioate (1:1);6-Quinoxalinamine,5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-,[R-(R*,R*)]-2,3-dihydroxybutanedioate (1:1);Brimonidine tartrate;AGN 190342LF;Brominide tartrate;Alphagan;Alphagan P;Brimonidine Purite;Mirvaso;(5-Bromo-quinoxalin-6-yl)-(4,5-dihydro-1H-imidazol-2-yl)-amine L-tartrate;109826-56-4;79570-19-7
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CAS No:
Description
UK 14,304 is a full α2-adrenergic receptor (α2-AR) agonist.Target: α2-adrenergic Receptor[3H]UK 14,034 is a full agonist at alpha 2-adrenergic receptors. [3H]UK 14,304 labels at least 2 specific binding sites in human brain that both have the characteristics of an alpha 2-adrenergic binding site. GTP decreases agonist binding at both of these sites, but with different potencies at each site [1-3].
Brimonidine Tartrate is the tartrate salt form of brimonidine, an imidazole derivative and a selective alpha-2 adrenergic receptor agonist. Upon ocular administration, brimonidine tartrate acts on the blood vessels causing them to constrict which leads to a decrease in the production of aqueous humor. Brimonidine tartrate also enhances the outflow of aqueous humor. This drug is used in the treatment of glaucoma to reduce intraocular pressure.|A quinoxaline derivative and ADRENERGIC ALHPA-2 RECEPTOR AGONIST that is used to manage INTRAOCULAR PRESSURE associated with OPEN-ANGLE GLAUCOMA and OCULAR HYPERTENSION.
Brimonidine tartrate Basic Attributes
442.22
441.028381
1308068-626-2
4S9CL2DY2H
C47419
S01EC54|D11AX21
2933990090
Characteristics
177
-0.52180
Off-white crystalline solid
207.5 °C
432.6°C at 760 mmHg
215.4ºC
-20°C Freezer
Safety Information
UN 2811 6.1 / PGIII
S36/37
Missing Phrase - N15.00950417-P305 + P351 + P338
H301-H315-H319-H335
|Danger|H301 (76.92%): Toxic if swallowed [Danger Acute toxicity, oral]|P260, P261, P264, P270, P271, P272, P280, P285, P301+P310, P301+P312, P302+P352, P304+P340, P304+P341, P305+P351+P338, P309+P311, P311, P312, P314, P321, P330, P332+P313, P333+P313, P337+P313, P342+P311, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 13 companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
Decrease of elevated intraocular pressure (IOP) in adult patients with open-angle glaucoma or ocular hypertension for whom monotherapy provides insufficient IOP reduction.|Mirvaso is indicated for the symptomatic treatment of facial erythema of rosacea in adult patients.,|Treatment of rosacea|Treatment of glaucoma
Compounds that bind to and activate ADRENERGIC ALPHA-2 RECEPTORS. (See all compounds classified as Adrenergic alpha-2 Receptor Agonists.)|Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)
5-Bromo-6-(2-imidazolin-2-ylamino)quinoxaline D-tartrate
Brimonidine tartrate Use and Manufacturing
Used to treat open-angle glaucoma or ocular hypertension
Human drugs -> Simbrinza -> EMA Drug Category|Ophthalmologicals -> Human pharmacotherapeutic group|Human drugs -> Mirvaso -> EMA Drug Category|Other dermatological preparations -> Human pharmacotherapeutic group|Human Drugs -> EU pediatric investigation plans|Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients
Computed Properties
Molecular Weight:442.22
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:5
Exact Mass:441.02840
Monoisotopic Mass:441.02840
Topological Polar Surface Area:177
Heavy Atom Count:27
Complexity:442
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
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