2,5-DICHLORO-3-(TRIFLUOROMETHYL)PYRIDINE

Preparation of (b) Preparation of Example 33 Synthesis of 2-(5-chloro-3-trifluoromethyl-2-pyridyloxymethyl)phenyl 5-methylisoxazol-3-yl ketone O-methyloxime THF (3 ml), Step 9 Methyl 4-{[3-chloro-5-(trifluoromethyl)-2-pyridyl]oxy}-5, 8-dimethyl-1, 1-dioxo-1, 2, 3, 4-tetrahydro-1lambda6-thiochromene-6-carboxylate 0.48 g (1.7 mmol) of methyl 5, 8-dimethyl-4-hydroxy-1, 1-dioxo-1, 2, 3, 4-tetrahydro-1lambda6-thiochromene-6-carboxylate and 0.4 g (1.9 mmol) of Reference Synthesis of (E)-2-[2-(5-chloro-3-trifluoromethylpyridin-2-yloxymethyl)phenyl]-2-methoxyimino-N-methylacetamide 2-(2-Hydroxymethylphenyl)-2-methoxyimino-N-methylacetamide (300 mg) was dissolved in THF (5 ml). 40% sodium hydride (65 mg) was added, and the mixture was stirred for 10 minutes. Reference Example 4 (E)-2-[2-(5-chloro-3-trifluoromethylpyridin-2-yloxymethyl)phenyl]-2-methoxyimino-N-methylacetamide 2-(2-Hydroxymethylphenyl)-2-methoxyimino-N-methylacetamide (300 mg) was dissolved in THF (5 ml). 60% Sodium hydride (65 mg) was added, and the mixture was stirred for 10 minutes. A stirred suspension of D7 (5.5 g, 27.5 MMOL), 3, 6-DICHLORO-5- TRIFLUOROMETHYLPYRIDINE (3.83 mL, 27.5 MMOL) (for synthesis see Tetrahedron, 1985, 41, 4057) and potassium carbonate (11.4 g, 82.6 MMOL) in dry N, N-DMF (100 mL) was heated at 120C for 24h. After cooling to ambient temperature, the mixture was poured into water (1 L), stirred for 1 h and then filtered. The residue was washed with water (3 x 150 mL and dried (MGS04) to afford the title compound (9.8 g).

Molecular Weight:215.98
XLogP3:3.3
Hydrogen Bond Acceptor Count:4
Exact Mass:214.9516389
Monoisotopic Mass:214.9516389
Topological Polar Surface Area:12.9
Heavy Atom Count:12
Complexity:161
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes