Hyodeoxycholic acid
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Hyodeoxycholic acid
structure -
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CAS No:
83-49-8
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Formula:
C24H40O4
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Chemical Name:
Hyodeoxycholic acid
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Synonyms:
Cholan-24-oic acid,3,6-dihydroxy-,(3α,5β,6α)-;5β-Cholan-24-oic acid,3α,6α-dihydroxy-;5β-Cholanic acid,3α,6α-dihydroxy-;(3α,5β,6α)-3,6-Dihydroxycholan-24-oic acid;3α,6α-Dihydroxy-5β-cholanoic acid;3α,6α-Dihydroxy-5β-cholanic acid;Hyodeoxycholic acid;Hyodesoxycholic acid;α-Hyodeoxycholic acid;3α,6α-Dihydroxy-5β-cholan-24-oate;6α-Hydroxylithocholic acid;3α,6α-Dihydroxy-5β-cholan-24-oic acid;7-Deoxyhyocholic acid;Iodeoxycholic acid;NSC 60672
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Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs
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CAS No:
Description
Hyodeoxycholic acid is a secondary bile acid formed in the small intestine by the gut flora, and acts as a TGR5 (GPCR19) agonist, with an EC50 of 31.6 µM in CHO cells.
Characteristics
77.76000
4.47790
1.1±0.1 g/cm3
198.5 °C
547.1±25.0 °C at 760 mmHg
298.8±19.7 °C
1.543
5.889mg/L(25 ºC)
Safety Information
NONH for all modes of transport
3
R36/37/38; R40
S26; S36/37/39; S36; S22
FZ2050000
Xn
|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 94 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hyodeoxycholic acid Use and Manufacturing
1. Used for biochemical research. 2. Suitable for type Ia, Ib hyperlipidemia, atherosclerosis. It has certain bacteriostatic effect on pertussis bacilli, diphtheria bacilli and staphylococcus aureus. It can be used as an anti-inflammatory drug to treat chronic bronchitis and viral upper respiratory tract inflammation in children. It is suitable for cholangitis, cholecystitis, cholelithiasis and other non-obstructive cholestasis; it can expel the gallbladder contrast medium out of the liver to help visualization. Can still promote intestinal fat breakdown and absorption of fat-soluble vitamins can be used for indigestion caused by liver and gallbladder diseases.
Computed Properties
Molecular Weight:392.6
XLogP3:4.9
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:392.29265975
Monoisotopic Mass:392.29265975
Topological Polar Surface Area:77.8
Heavy Atom Count:28
Complexity:605
Undefined Atom Stereocenter Count:10
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Drug Function and Efficacy
It has antipyretic, brain tissue protective and liver damage resistance effects.
Registered Holders
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Gansu Xinyi Tiansen Pharmaceutical Co., Ltd.
Active
China
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Nanjing Xinbai Pharmaceutical Co., Ltd.
Active
China
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