4-Amino-1-naphthalenesulfonic acid

slightly greyish to beige powder and granules

Naphthionic acid is an aminonaphthalenesulfonic acid.

Naphthylamine is sulfonated to obtain 4-amino-1-naphthalenesulfonic acid, which is neutralized to obtain sodium salt. The sulfonation reaction is carried out in the solvent trichlorobenzene, the reaction temperature is 185-190°C, the vacuum degree is controlled at 2.67-5.33kPa, the temperature is kept for 3.5 hours, and the end point is checked by sampling. After being qualified, the temperature is lowered to 150°C, and alkaline water is added to neutralize, and the pH is controlled to be 8-9. At 70-80°C, add carbolic acid and alkali sulfide to the neutralized solution, heat up to 90-95°C, and then stand still to separate layers. The upper layer liquid is concentrated, cooled, crystallized, and centrifuged to dry the sodium salt product. The yield was 83%. The lower trichlorobenzene is washed and recycled with water.

As an antidote to nitrite and iodine poisoning, it is also an intermediate for various azo dyes.

Molecular Weight:223.25
XLogP3:1.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:223.03031432
Monoisotopic Mass:223.03031432
Topological Polar Surface Area:88.8
Heavy Atom Count:15
Complexity:322
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes