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8-Chlorotheophylline

CAS No:
85-18-7
Formula:
C7H7ClN4O2
Synonyms:
NSC 6113;Theoclate;AKOS BBS-00006435;8-Chlorothephyline;chlorotheophylline;8-chloro-theophyllin;8-CHLOROTHEOPHYLLINE;LABOTEST-BB LT00138074;Theophylline, 8-chloro-;8-Chlorotheophylline,99%
China Export:
From 2018.11 to 2019.11, total export volume of 8-Chlorotheophylline from China was 112,377,052KG while total export value was $2,146,929,254. The biggest proportion of exporting volume in the last 12 months was 9.88% in 2019.03.

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Description

white to light yellow crystal powder

Basic Attributes

CAS No：

85-18-7
Molecular Formula ：

C7H7ClN4O2
Molecular Mass ：

214.61
Exact Mass ：

214.025757
PSA ：

69.3 A^2
LogP ：

-0.42
EINECS ：

201-590-4
InChIKeys ：

RYIGNEOBDRVTHA-UHFFFAOYSA-N
H-bond Acceptor ：

3
H-bond Donor ：

1
RBN ：

0

Characteristics

Density ：

1.6±0.1 g/cm3
Melting Point ：

290 °C (dec.)(lit.)
Bolling Point ：

455.0±55.0 °C at 760 mmHg
Flash Point ：

229.0±31.5 °C
Refractive Index ：

1.631
Solubility ：

H2O: SLIGHTLY soluble ;soluble in sodium hydroxide.
Storage Condition ：

Refrigerator
BRN ：

203068

Safety Information

Packing Group ：

III
Hazard Class ：

6.1(b)
HS Code ：

2933990090
UN No. ：

2811
WGK_Germany ：

3
Risk Code ：

20/21/22-36/37/38-22
Safety Instructions ：

36-37/39-26
RTECS No. ：

XH5063000
Dangerous Mark ：

Xn
P Code ：

P264, P270, P301+P312, P330, P501
Hazard Statements ：

H302

Product Usage

A stimulant drug. It can be used as a binding agent to form stable salts of pharmaceutical drugs. Intermediate of anti-allergic drugs

Production Methods

Derived from caffeine by chlorination and hydrolysis. In the reaction pot, add caffeine, carbon tetrachloride-nitrobenzene mixture and iodine tablets, raise the temperature to below 80 ℃, and react with chlorine gas for 3 hours. The temperature was raised to 90-95°C, and the chlorine was passed for more than 5 hours. The reaction solution was completely clear to obtain 7, 8-dichlorocaffeine. Add water and heat to distill to make the distillate clear without formaldehyde smell. Freeze and crystallize, spin filter, wash with ethanol and chloroform in order, spin dry to obtain 8-chlorotheophylline. The yield was 60%.

Material ：

1,3-DIMETHYLURICACID, Iodine, Iodine, 1,3-Dimethyl-8-nitro-3,7-dihydro-1H-purine-2,6-dione, CAFFEINE, Caffeine, Hydrochloric Acid, Theophylline

China 8-Chlorotheophylline Export Data

Data referenced from General Administration of Customs,P.R.China

2018.11-2019.11 China - America 8-Chlorotheophylline Export Data

From 2018.11 to 2019.11, total export volume of 8-Chlorotheophylline from China to America was 15,218,209KG while total export value was $257,443,342. The biggest proportion of exporting volume in the last 12 months was 13.24% in 2018.11.

2018.11-2019.11 China 8-Chlorotheophylline Export Data

From 2018.11 to 2019.11, total export volume of 8-Chlorotheophylline from China was 112,377,052KG while total export value was $2,146,929,254. The biggest proportion of exporting volume in the last 12 months was 9.88% in 2019.03.

8-Chlorotheophylline

SDS

8-Chlorotheophylline

Description

Basic Attributes

Characteristics

Safety Information

Product Usage

Production Methods

Material and Products

China 8-Chlorotheophylline Export Data

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