Butyl phthalyl butyl glycolate

336.380

336.38

201-624-8

I5LOD5H050

DTXSID7023938

COLORLESS LIQUID

2917349000

78.90000

4.46

Clear colorless liquid

1.097 g/cm³

<-35 °C

345 °C

185.5±23.2 °C

1.501

12mg/L(20 ºC)

7.07X10-6 mm Hg at 25 deg C (est)

11.6 (Air = 1)

ODORLESS

TASTELESS

Henry's Law constant = 2.06X10-8 atm-cu m/mol at 25 °C (est)

Conversion factor: 13.73 mg/cu m= 1 ppm|... Resistance to migration from polymers, low temperature flexibility ... compatibility with polar polymers and additives over a wide range of compositions. /Phthalate esters/|Phthalate esters would be expected to have UV maxima in the 230 nm and 270 nm regions. /Phthalate esters/|Hydroxyl radical reaction rate constant = 9.74X10-12 cu cm/molec-sec at 25 °C (est)

62-61-51

S61-S53-S45

TI0535000

N-T

VERY STABLE

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

Butylphthalate butyl glycolate is an indirect food additive for use only as a component of adhesives.|Butylphthalyl butyl glycolate is classified as a plasticizer, when migrating from food-packaging material.

Nat'l Research Council Canada; Phthalate Esters in the Aquatic Environment (1980) NRCC No. 17583|USEPA; Ambient Water Quality Criteria Doc: Phthalate Esters (1980) EPA 440/5-80-067|USEPA/ECAO; Atlas Document for: Phthalate Esters (1980)

SLIGHT, WHEN EXPOSED TO HEAT OR FLAME; CAN REACT WITH OXIDIZING MATERIALS.

Water or foam may cause frothing.

SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.

| 1 - Materials that, under emergency conditions, can cause significant irritation.| 1 - Materials that must be preheated before ignition can occur. Materials require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur.| 0 - Materials that in themselves are normally stable, even under fire conditions.

Butyl glycolyl butyl phthalate was identified in the fly ash from combined coal/refuse combustion(1).

SOURCE DOMINATED: Butyl glycolyl butyl phthalate was detected in the air at a Hamilton, Ontario, water works plant located adjacent to a municipal incinerator, at a concentration of 750 ng/cu m(1).

MICE INJECTED IP WITH 60 MG/KG HEXOBARBITAL, 30 MIN AFTER PRETREATMENT WITH 500 MG/KG BUTYLGLYCOLYL BUTYL PHTHALATE SHOWED AN INCR HEXOBARBITAL INDUCED SLEEPING TIME, WHILE MICE TREATED WITH 250 MG/KG BUTYLGLYCOLYL BUTYL PHTHALATE DID NOT.

LD50 Rat oral 7000 mg/kg|LDE50 Rat ip 6889 mg/kg|LD50 Mouse oral 12567 mg/kg|LD50 Mouse ip 6880 mg/kg

/AQUATIC SPECIES/ The study was conducted to determine the effects of treatment and seawater dilution of municipal wastewater on marine organisms. An experimental facility was built in southeast Florida that provided both unchlorinated and chlorinated effluent from three standard treatments: primary settling, chemical flocculation, and activated sludge secondary treatment. Exposure tests lasting longer than one month were conducted on the sheepshead minnow (Cyprinodon variegatus) and the pink shrimp (Penaeus duorarum), with each of these six effluent types at seawater dilution ratios of 30:1, 100:1, and 300:1. The shrimp showed a much more sensitive response than the minnow. Almost 100% mortality occurred for shrimp exposed to the unchlorinated 30:1 seawater dilutions of primary-settled wastewater, while mortality for the other two effluents were similar to controls. Mortality could not be attributed to any of the chemicals measured in the wastewater. For the 30:1 dilution experiments, chlorination usually resulted in much higher toxicity; increasing the dilution factor from 30:1 to 100:1 reduced the mortality observed (in both unchlorinated and chlorinated tests) essentially to control levels. Little bioaccumulation of metals or chlorinated organics in exposed specimens.

The group at greatest risk is medical patients receiving blood transfusions and, especially, those requiring regular dialysis on a kidney machine.

Butyl glycolyl butyl phthalate's production and use as a plasticizer(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 1.5X10+4(SRC), determined from a structure estimation method(2), indicates that butyl glycolyl butyl phthalate is expected to be immobile in soil(SRC). Volatilization of butyl glycolyl butyl phthalate from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 2.1X10-8 atm-cu m/mole(SRC), using a fragment constant estimation method(3). Butyl glycolyl butyl phthalate is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 7.1X10-6 mm Hg(SRC), determined from a fragment constant method(4). Rates of 84.5 to >99% biodegradation in 24 hrs using a semi-continuous activated sludge test(5) suggests that biodegradation may be an important environmental fate process in soil(SRC).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 1.5X10+4(SRC), determined from a structure estimation method(2), indicates that butyl glycolyl butyl phthalate is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 2.1X10-8 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). According to a classification scheme(5), an estimated BCF of 300(SRC), from an estimated log Kow of 4.15(6) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is high(SRC). However, bioconcentration studies on compounds which are structurally similar suggest that bioconcentration may be lower than that indicated by the regression-derived equations due to the ability of aquatic organisms to readily metabolize this class of compounds(8). Hydrolysis is expected to be an important process(SRC) based on estimated hydrolysis half-lives of 11 and 1 days at pHs 7 and 8, respectively(9). A 95% biodegradation in 2 days using the river die-away test(10) suggests that biodegradation may be an important environmental fate process in water(SRC).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), butyl glycolyl butyl phthalate, which has an estimated vapor pressure of 7.1X10-6 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase butyl glycolyl butyl phthalate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 40 hours(SRC), calculated from its rate constant of 9.7X10-12 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Particulate-phase butyl glycolyl butyl phthalate may be removed from the air by wet or dry deposition(SRC). Butyl glycolyl butyl phthalate does contain chromophores that absorb at wavelengths >290 nm(4) and therefore may be susceptible to direct photolysis by sunlight(SRC).

The rate constant for the vapor-phase reaction of butyl glycolyl butyl phthalate with photochemically-produced hydroxyl radicals has been estimated as 9.7X10-12 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 40 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). A base-catalyzed second-order hydrolysis rate constant of 7.0 L/mole-sec(SRC) was estimated using a structure estimation method(2); this corresponds to half-lives of 11 and 1 days at pH values of 7 and 8, respectively(2). Butyl glycolyl butyl phthatalate does contain chromophores that absorb at wavelengths >290 nm(3) and therefore may be susceptible to direct photolysis by sunlight(SRC).

An estimated BCF of 300 was calculated in fish for butyl glycolyl butyl phthalate(SRC), using an estimated log Kow of 4.15(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is high(SRC). However, bioconcentration studies on compounds which are structurally similar suggest that bioconcentration may be lower than that indicated by the regression-derived equations due to the ability of aquatic organisms to readily metabolize this class of compounds(4).

5.01e+03 L/kg|Using a structure estimation method based on molecular connectivity indices(1), the Koc of butyl glycolyl butyl phthalate can be estimated to be 1.5X10+4(SRC). According to a classification scheme(2), this estimated Koc value suggests that butyl glycolyl butyl phthalate is expected to be immobile in soil.

The Henry's Law constant for butyl glycolyl butyl phthalate is estimated as 2.1X10-8 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that butyl glycolyl butyl phthalate is expected to be essentially nonvolatile from water surfaces(2). Butyl glycolyl butyl phthalate is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 7.1X10-6 mm Hg(SRC), determined from a fragment constant method(3).

SURFACE WATER: Butyl glycolyl butyl phthalate at a concn of greater than 1 ug/L was detected in 13% of 30 water samples collected from unpolluted upstream reaches, polluted stretches, and downstream from major discharges into the Delaware River, 1976(1). Butyl glycolyl butyl phthalate was found in the Inner Harbor Navigation Channel of Lake Pontchartrain, LA, in 1980, concn not detected to 0.04 ppb(2). Butyl glycolyl butyl phthalate was detected in Lake Michigan and Lake Erie, 1978(3). Butyl glycolyl butyl phthalate was detected in 23 of 204 water samples obtained from waterway sites collected throughout the United States, 1975-6(4).|SURFACE WATER: Phthalate esters in fresh ... waters: Lake Ontario (lakewide), 2-50 ug/L; Lake Erie (lakewide), 7-6 ug/L; Lake Huron (lakewide), 8-3 ug/L; Lake Superior (lakewide), <0.1 ug/L /From Table; Phthalate esters/|DRINKING WATER: Butyl glycolyl butyl phthalate has been qualitatively detected in drinking water(1,2).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 430 workers (49 of these were female) were potentially exposed to butyl glycolyl butyl phthalate in the US(1). Occupational exposure to butyl glycolyl butyl phthalate may occur through inhalation and dermal contact with this compound at workplaces where butyl glycolyl butyl phthalate is produced or used. Use data indicate that the general population may be exposed via dermal contact with consumer products containing this compound(SRC).

Butyl glycolyl butyl phthalate was identified, not quantified, in the adipose tissue in 6 of 46(1) and 8 of 46(2) humans sampled in the US.

BUTYLGLYCOLYLBUTYL PHTHALATE WAS ADMIN IN DIET TO MALE SPRAGUE DAWLEY RATS, BEAGLE DOGS & MINIATURE PIGS IN DOSE OF 50 MG/KG FOR 21-28 DAYS BEFORE ORAL ADMIN OF SINGLE DOSE OF SAME CMPD LABELED WITH (14)C IN CARBONYL GROUP. IT WAS EXCRETED MAINLY IN THE URINE IN RATS (77-83%), DOGS (72-75%) AND PIGS (68-89%).

BUTYLGLYCOLYLBUTYL PHTHALATE OR DIISOOCYTL PHTHALATE WAS ADMIN IN DIET TO MALE SPRAGUE DAWLEY RATS, BEAGLE DOGS & MINIATURE PIGS IN DOSE OF 50 MG/KG FOR 21-28 DAYS BEFORE ORAL ADMIN OF SINGLE DOSE OF SAME CMPD LABELED WITH (14)C IN CARBONYL GROUP. DIISOOCYTL PHTHALATE WAS LESS READILY METABOLIZED THAN BUTYLGLYCOLYL BUTYL PHTHALATE BY ALL SPECIES.

/ALTERNATIVE and IN VITRO TESTS/ Comparative toxicity of phthalate esters to HeLa-S3 cells was studied by determining their effect on doubling time of the cells. The toxicity of the esters decreasing in order: diethyl phthalate, butylphthalyl butyl glycolate, di-iso-butyl phthalate, ethyl phthalyl ethyl glycolate, bis(2-ethylhexyl) phthalate, dimethyl isophthalate, dibutyl phthalate, methyl phthalyl ethyl glycolate, dimethyl phthalate, and dioctyl phthalate.

butyl phthalyl butyl glycolate

1,2-Benzenedicarboxylic acid, 1-(2-butoxy-2-oxoethyl) 2-butyl ester: ACTIVE|The first step, alcoholysis of phthalic anhydride (PA) to give the monoester, is rapid and goes to completion. The reaction generally starts at elevated temperatures and proceeds exothermically. The second step is the conversion of the monoester to a diester with the formation of water. This is a reversible reaction and proceeds more slowly than the first, thus determining the overall rate of reaction. To shift the equilibrium towards the diester, the water of reaction is removed by distillation. The rate of reaction can be influenced by the choice of catalyst and the reaction temperature. For fast conversion rates, high reaction temperatures are generally used. However, these are influenced by the boiling point of the alcohol and/or the type of catalyst. ... Currently, nearly all major phthalate producers use amphoteric catalysts for the esterification of high boiling alcohols. ... The reaction temperatures for the amphoteric catalysts are about 200 °C. At this temperature side reactions are minimized, and the alcohol can be recycled without purification. By using this type of catalyst, over 99.5 % conversion to diester can be achieved. /Phthalates/|IT IS COMPATIBLE WITH POLYVINYL CHLORIDE, POLYVINYL ACETATE, ETHYL CELLULOSE, & NITRILE RUBBER, & IS USED FOR MAKING A VARIETY OF PACKAGING FILMS, TO WHICH IT IMPARTS VERY GOOD STABILITY TO HEAT & LIGHT.

BUTYLPHTHALYL BUTYL GLYCOLATE AND 3 OTHER PHTHALIC ESTERS WERE SEPARATED QUANTITATIVELY ON 2% OV-25, OV-7, AND OV-210 GLASS COLUMNS BY EQUAL CHARGE GAS CHROMATOGRAPHY.|This method is applicable to natural/ waters, sediments, and benthic organisms from the Mississippi River, the Mississippi delta system, and the adjacent Gulf of Mexico. Samples were extracted with hexane and the extract concentrated to 5 ml. Two chromatographic columns were used to separate the chlorinated hydrocarbons: 5% QF-1 on 80-90 Gas Chrom Q and 1.5% OV-17 plus 1; 95% QF-1 on 80-90 Gas Chrom Q. The extract was examined by GLC using an electron capture detector without further cleanup. Butylphthalyl butyl glycolate was one of 2 plasticizers that was identified by this analysis.

Cosmetics -> Film forming