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Phthalylsulfathiazole

Phthalylsulfathiazole structure

CAS No:
85-73-4
Formula:
C17H13N3O5S2
Chemical Name:
Phthalylsulfathiazole
Synonyms:
Benzoic acid,2-[[[4-[(2-thiazolylamino)sulfonyl]phenyl]amino]carbonyl]-;Phthalanilic acid,4′-(2-thiazolylsulfamoyl)-;2-[[[4-[(2-Thiazolylamino)sulfonyl]phenyl]amino]carbonyl]benzoic acid;AFI-Ftalyl;(o-Carboxybenzoyl)-p-aminophenylsulfonamidothiazole;Cremothalidine;Enteramida;Entero-sulfina;Entexidina;Intestiazol;Phthalazol;2-(N4-Phthalylaminobenzenesulfonamide)thiazole;Phthalylnorsulfazole;2-(N4-Phthalylsulfanilamido)thiazole;Phthalylsulfathiazole;Phthalylsulfonazole;Sulfacetil;Sulfaphthalazole;Sulfathalidine;Sulftalyl;Taleudron;Talidine;Taloudron;Thalazole;Thalistanin;Thalistatyl;4′-(2-Thiazolylsulfamoyl)phthalanilic acid;4′-(2-Thiazolylsulfamyl)phthalanilic acid;Ultratiazol;Phthalylsulphathiazole;Ftalazol;Phthalidin;Thalinil;Ftalysept;Ftalil-Esteve;Phtalazol;Ftalil-Septol;Sulphaphthalyl;NSC 66454;NSC 683525;2-[[4-(1,3-Thiazol-2-ylsulfamoyl)phenyl]carbamoyl]benzoic acid;2-([4-[(1,3-Thiazol-2-yl)sulfamoyl]phenyl]carbamoyl)benzoic acid
Categories:
Organic Chemistry > Amides

Description

Phthalylsulfathiazole is a kind of sulfonamides used as an antibacterial drug.

Phthalylsulfathiazole is a sulfonamide incorporating 2-carboxybenzamido and 1,3-thiazol-2-yl moieties that is a broad-spectrum antibiotic indicated in the treatment of dysentery, colitis, gastroenteritis and intestinal surgery. It is a sulfonamide, a member of 1,3-thiazoles, a dicarboxylic acid monoamide and a sulfonamide antibiotic. It derives from a phthalic acid.|Phthalylsulfathiazole is a broad spectrum antibiotic which is part of the drug class, sulfonamides. It was used as an antibiotic for bowel surgery, and for infections of the colon.|Phthalylsulfathiazole is a broad spectrum antimicrobial agent. Phthalylsulfathiazole is used in the treatment of dysentery, colitis, and gastroenteritis.

Phthalylsulfathiazole Basic Attributes

Molecular Weight：

403.44

Exact Mass：

403.43

EC Number：

201-627-4

UNII：

6875L5852V

NSC Number：

758159|683525|66454

DSSTox ID：

DTXSID8023470

NCI Thesaurus Code：

C80790

ATC Code：

A - Alimentary tract and metabolism

HScode：

2935009090

Characteristics

PSA：

162

XLogP3：

1.54

Density：

1.6±0.1 g/cm3

Melting Point：

273 °C

Boiling Point：

579ºC at 760 mmHg

Flash Point：

304ºC

Refractive Index：

1.715

Storage Conditions：

-20°C

Toxicity：

LD50 i.p. in mice: 920 mg/kg (Mattis)

Collision Cross Section：

194.9 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

Packing level：

III

Hazard category：

6.1(b)

Transport codes：

3249

safety instructions：

24/25

RTECS Number：

TH8575000

GHS Classification：

H412 (100%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]|P273, and P501|Aggregated GHS information provided by 4 companies from 2 notifications to the ECHA C&L Inventory.

Drug Information

MeSH Entry Terms：

ftalazol

Phthalylsulfathiazole Use and Manufacturing

Uses

antibacterial

Manufacturing Info：

Benzoic acid, 2-[[[4-[(2-thiazolylamino)sulfonyl]phenyl]amino]carbonyl]-: INACTIVE

Use Classification：

Pharmaceuticals

Computed Properties

Molecular Weight:403.4
XLogP3:1.1
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:6
Exact Mass:403.02966287
Monoisotopic Mass:403.02966287
Topological Polar Surface Area:162
Heavy Atom Count:27
Complexity:643
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Phthalic anhydride

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