 Home > Encyclopedia > Pyridoxamine

Pyridoxamine

Pyridoxamine structure

CAS No:
85-87-0
Formula:
C8H12N2O2
Chemical Name:
Pyridoxamine
Synonyms:
3-Pyridinemethanol,4-(aminomethyl)-5-hydroxy-6-methyl-;Pyridoxamine;4-(Aminomethyl)-5-hydroxy-6-methyl-3-pyridinemethanol;4-(Aminomethyl)-3-hydroxy-5-(hydroxymethyl)-2-methylpyridine;Pyridoxylamine;1801892-38-5;2087491-59-4;2376308-84-6
Categories:
Active Pharmaceutical Ingredients > Vitamins and Minerals Medicines

Description

Pyridoxylamine is an advanced glycation end production (AGEs) and lipoxidation end products (ALEs) inhibitor, to protect against diabetes-induced retinal vascular lesions.

Solid

Pyridoxamine is a monohydroxypyridine that is pyridine substituted by a hydroxy group at position 3, an aminomethyl group at position 4, a hydroxymethyl group at position 5 and a methyl group at position 2. The 4-aminomethyl form of vitamin B6, it is used (in the form of the hydrochloride salt) for treatment of diabetic nephropathy. It has a role as a human metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite, a plant metabolite, a mouse metabolite, an iron chelator and a nephroprotective agent. It is a hydroxymethylpyridine, a monohydroxypyridine, an aminoalkylpyridine and a vitamin B6. It is a conjugate base of a pyridoxaminium(1+).|Pyridoxamine has been used in trials studying the treatment of Kidney Stones.|The 4-aminomethyl form of VITAMIN B 6. During transamination of amino acids, PYRIDOXAL PHOSPHATE is transiently converted into pyridoxamine phosphate.

Pyridoxamine Basic Attributes

Molecular Weight：

168.2

Exact Mass：

168.19

EC Number：

201-640-5

UNII：

6466NM3W93

DSSTox ID：

DTXSID6046929

HScode：

2933399090

Characteristics

PSA：

79.4

XLogP3：

0.74690

Appearance：

Solid

Density：

1.282g/cm3

Melting Point：

193-193.5 °C

Boiling Point：

460.1ºC at 760 mmHg

Flash Point：

232.1ºC

Refractive Index：

1.617

Water Solubility：

815 mg/mL

Collision Cross Section：

134 Å² [M+H]+ [CCS Type: DT, Method: single field calibrated with Agilent tune mix (Agilent)]|135.79 Å² [M+H]+ [CCS Type: DT, Method: stepped-field]|148.49 Å² [M+Na]+ [CCS Type: DT, Method: stepped-field]|140.12 Å² [M-H]- [CCS Type: DT, Method: stepped-field]|130 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine]|133.7 Å² [M+H]+ [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|144.1 Å² [M+Na]+ [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|133.9 Å² [M-H]- [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|136.4 Å² [M-H]-

Drug Information

MeSH：

A group of water-soluble vitamins, some of which are COENZYMES. (See all compounds classified as Vitamin B Complex.)

MeSH Entry Terms：

Pyridoxamine

Computed Properties

Molecular Weight:168.19
XLogP3:-1
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:168.089877630
Monoisotopic Mass:168.089877630
Topological Polar Surface Area:79.4
Heavy Atom Count:12
Complexity:143
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of Pyridoxamine

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

Pyridoxamine

CAS No.: 85-87-0

Content: 99.00%

Inquiry
Wuhan Pnq Int Trade Co., Ltd Contact Supplier

CN
3 YRS

Business licensed

Trader Supplier of Apigenin,PQQ,NMNH

Pyridoxamine

Unit Price: $100 /KG EXW

CAS No.: 85-87-0

Grade: Pharmaceutical grad

Content: 99%

Inquiry