D-Tagatose
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D-Tagatose
structure -
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CAS No:
87-81-0
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Formula:
C6H12O6
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Chemical Name:
D-Tagatose
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Synonyms:
D-Tagatose;Tagatose,D-;D-lyxo-2-Hexulose
- Categories:
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CAS No:
Description
Tagatose is a white, anhydrous crystalline solid. It is a carbohydrate, a ketohexose, an epimer of D-fructose inverted at C-4. It can exist in several tautomeric forms. white to off-white crystalline powder
Keto-D-tagatose is the straight-chain keto form of D-tagatose. It is an enantiomer of a keto-L-tagatose.|Tagatose is a functional sweetener. It is a naturally occurring monosaccharide, specifically a hexose. It is commonly found in dairy with a similar texture and sweetened capacity to sucrose but with only a third of the calories. It is approved as a food additive as a low calorie sweetener. Additionally, it is under investigation by Spherix for the treatment of obesity and type II diabetes.
Characteristics
118
-3.202
1.65 at 15 deg C
134.5 °C
551.7±50.0 °C at 760 mmHg
301.5±26.6 °C
1.574
H2O: 0.1 g/mL, clear, colorless
Keep container tightly closed in a dry and well-ventilated place.
5.2X10-9 mm Hg at 25 deg C (est)
D25 -5° (c = 1 in water)
Safety Information
NONH for all modes of transport
3
36/37/38
24/25-36-26
WW1100000
Xi
Stable under recommended storage conditions.
Drug Information
Intended for use as a therapeutic adjunct in the treatment of type II diabetes.
Oral tagatose significantly blunts the rise in plasma glucose seen after oral glucose in patients with diabetes mellitus in a dose-dependent manner without significantly affecting insulin levels. The minimal elevation of plasma tagatose levels in normal patients and the adverse gastrointestinal effects seen following larger doses of tagatose support poor absorption of this hexose and suggest that tagatose may act by attenuating glucose absorption in the intestine.
Organic chemicals that form two or more coordination links with an iron ion. Once coordination has occurred, the complex formed is called a chelate. The iron-binding porphyrin group of hemoglobin is an example of a metal chelate found in biological systems. (See all compounds classified as Iron Chelating Agents.)
Only 15-20 percent of tagatose is absorbed in the small intestine.
Tagatose does not influence the level of blood glucose nor insulin levels.
he steps in the metabolism of tagatose are identical to those for fructose or fruit sugar but tagatose is incompletely absorbed. Only 15-20 percent of tagatose is absorbed in the small intestine. The major part of ingested tagatose is fermented in the colon by indigenous microflora, resulting in the production of short-chain fatty acids. The short chain fatty acids are absorbed almost completely and metabolized.
D-tagatose
Computed Properties
Molecular Weight:180.16
XLogP3:-3.2
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:5
Exact Mass:180.06338810
Monoisotopic Mass:180.06338810
Topological Polar Surface Area:118
Heavy Atom Count:12
Complexity:147
Defined Atom Stereocenter Count:3
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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