Sodium pantothenate

241.22

241.092621

212-768-6

DTXSID4047173

2924199090

110

-1.98710

white powder

171-178 °C

551.5°C at 760 mmHg

287.3ºC

27 ° (C=5, H2O)

2-8°C

D25 +27.1° (c = 2)

36/37/38-48-41-37/38-20/21/22

26-36-45-36/37/39-22-24/25

Xi,Xn

Stable under normal temperatures and pressures.

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.

Sodium pantothenate used as a nutrient and/or dietary supplement in animal drugs, feeds, and related products is generally recognized as safe when used in accordance with good manufacturing or feeding practice.

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 39 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Topical application of pantothenate is widely used in clinical practice for wound healing.

Distribution of pantothenate from plasma into liver was very rapid; during 10 min after iv admin about 80% of dose was cleared from plasma.|Total blood pantothenic acid levels were higher after oral admin of 21.6 uM/kg pantethine than after calcium pantothenate in rats but no difference in amount of bound pantothenic acid. Max concentrations were observed at 2-4.5 hr after ingestion of both groups.|Total pantothenic acid excretions after 24 hr oral admin to rats were 29% and 18% after administration of pantethine and calcium pantothenate, respectively. Pantethine was more readily absorbed from GI tract than calcium pantothenate.

... To test the functional effect of pantothenate on dermal fibroblasts, cells were cultured and in vitro proliferation tests were performed using a standardized scratch test procedure. For all three donors analyzed, a strong stimulatory effect of pantothenate at a concentration of 20 ug/mL on the proliferation of cultivated dermal fibroblasts was observed. To study the molecular mechanisms resulting in the proliferative effect of pantothenate, gene expression was analyzed in dermal fibroblasts cultivated with 20 ug/mL of pantothenate compared with untreated cells using the GeneChip Human Exon 1.0 ST Array. A number of significantly regulated genes were identified including genes coding for interleukin (IL)-6, IL-8, Id1, HMOX-1, HspB7, CYP1B1 and MARCH-II. Regulation of these genes was subsequently verified by quantitative real-time polymerase chain reaction analysis. Induction of HMOX-1 expression by pantothenol and pantothenic acid in dermal cells was confirmed on the protein level using immunoblots. Functional studies revealed the enhanced suppression of free radical formation in skin fibroblasts cultured with panthenol. In conclusion, these studies provided new insight in the molecular mechanisms linked to the stimulatory effect of pantothenate and panthenol on the proliferation of dermal fibroblasts. /Calcium pantotenate/

Contains ~5% isopropanol as solvent of crystallization.

.beta.-Alanine, N-[(2R)-2,4-dihydroxy-3,3-dimethyl-1-oxobutyl]-, sodium salt (1:1): ACTIVE

USE OF SILICA GEL FOR SEPARATION OF WATER-SOL VITAMINS BY THIN-LAYER CHROMATOGRAPHY. SEPARATION OF VITAMIN MIXT CONTAINING SODIUM PANTOTHENATE WAS PERFORMED IN 6 DEVELOPING SYSTEMS. COLORING AGENTS & UV LIGHT USED IN DETECTION. VITAMINS WERE SEPARABLE & RF VALUES REPORTED.|PANTOTHENIC ACID (VITAMIN B5), SOME OF ITS SALTS, & SOME OF ITS PHARMACEUTICAL DEGRADATION PRODUCTS WERE THIN-LAYER-CHROMATOGRAPHED.

Cosmetics -> Hair conditioning