(-)-Securinine
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(-)-Securinine
structure -
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CAS No:
5610-40-2
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Formula:
C13H15NO2
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Chemical Name:
(-)-Securinine
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Synonyms:
8H-6,11b-Methanofuro[2,3-c]pyrido[1,2-a]azepin-2(6H)-one,9,10,11,11a-tetrahydro-,(6S,11aR,11bS)-;Securinine,(-)-;Securinine;Securinan-11-one;6,10-Methanopyrido[1,2-a]azepine-Δ9(6H),α-acetic acid,1,2,3,4,10,10a-hexahydro-10-hydroxy-,γ-lactone;(6S,11aR,11bS)-9,10,11,11a-Tetrahydro-8H-6,11b-methanofuro[2,3-c]pyrido[1,2-a]azepin-2(6H)-one;Securinin;(-)-Securinine;l-Securinine;NSC 107413;780-62-1;13425-54-2
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CAS No:
Description
(-)-Securinine is plant-derived alkaloid and also a GABAA receptor antagonist.
Securinine is a member of indolizines.
Characteristics
29.5
1.1
yellow
1.3±0.1 g/cm3
142-143 °C
459ºC at 760 mmHg
197.0±19.6 °C
1.633
DMSO: ≥25mg/mL
-20°C Freezer
D20 -1042° (c = 1 in alc)
146.4 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Safety Information
NONH for all modes of transport
3
23/24/25-22
36/37/39-45
VS4115000
T,Xn
P264, P270, P301+P312, P330, P501
H302
Computed Properties
Molecular Weight:217.26
XLogP3:1.1
Hydrogen Bond Acceptor Count:3
Exact Mass:217.110278721
Monoisotopic Mass:217.110278721
Topological Polar Surface Area:29.5
Heavy Atom Count:16
Complexity:426
Defined Atom Stereocenter Count:3
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Drug Function and Efficacy
This product has a selective excitatory effect on the spinal cord, enhancing reflexes and muscle tension.
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