Securinega suffruticosa Extract 95% securinine 95% 5610-40-2

Pharmacological effects

1. central excitatory effect: the central nervous system, especially the spinal cord with obvious excitatory effect, a small amount to improve the excitability of reflexes, shorten the latency of reflexes, a large number of the production of strychnine-like convulsions. Monohypericin and dihydromonohypericin can cause such convulsions. Monohypericin can significantly increase muscle tone, but there is no direct excitatory effect on neuromuscular specimens, no inhibition of cholinesterase and monoamine oxidase, so it is the result of the action of the centre. The effect on the cerebral cortex is to make the conditioned reflexes strengthened, the latency period is shortened, and the electroencephalogram shows an increase in fast waves and a decrease in slow waves. Hagaricine can also increase the oxygen consumption of the brain, spinal cord, liver, kidneys, bone and armour muscles. Excitatory effect on the spinal cord, can be used to treat the sequelae of poliomyelitis. Can also be used to treat facial nerve paralysis, not only can make the paralysed nerve recovery, but also can make the early patients with complete degeneration of the nerve rate significantly reduced. A leaf Hagi alkaloids on the spinal cord has a similar excitatory effect of strychnine, but the toxicity is much smaller than strychnine, frogs, mice, rats, rabbits and cats injected with a leaf Hagi alkaloids produced tonic and paroxysmal convulsions; a leaf Hagi alkaloids decoction also have central excitatory effect, but the degree of the weaker.