Benzenesulfinic acid, 4-fluoro-, sodium salt (1:1)

white powder

Take 250mL of mono vial, P-fluorobenzenesulfonyl chloride (48.5 mmol, 9.4 g, 1.0 equiv) was added, Sodium sulfite (97 mmol, 12.2 g, 2.0 equiv), Sodium bicarbonate (97 mmol, 8.1 g, 2.0 equiv)Add 60 mL of water, Equipped with reflux condenser, 80 ° C for 4 h.The reaction ends, Dry water, Add methanol dissolved to filter, And then spin dry methanol to white solid 10.2g, Yield 99percent.General procedure: The aryl bromide (2.00 mmol), Mg (194 mg, 8.00 mmol) and an I2 crystal were weighed in a 2-5 ml Smith process vial and 2.5 ml dry THF was added after flushing with nitrogen. The mixture was heated in a microwave reactor for 1 h at 100 °C. In a second vial DABSO (121 mg, 0.500 mmol) was weighed and cooled on ice followed by slow addition of the Grignard reagent by syringe and the mixture was then stirred for 3 hours at 0 °C and then allowed to reach room temperature. The reaction mixture was poured into 10 ml of diethyl ether and was extracted with 3×10 ml of 10percent Na2CO3 solution. The aqueous layers were acidified by careful addition of 3 ml of concentrated H2SO4while cooling on ice and was then extracted with 3×10 ml of diethyl ether. The organic layers were then extracted with 3×10 mlof 10percent Na2CO3 solution. The water was evaporated in vacuo. 20 ml of absolute ethanol was added to the residue and refluxed for 10 minutes. The round bottomed flask was allowed to cool and was then filtered through a P4 frit, and the ethanol extraction was repeated. The ethanol was evaporated in vacuoand the product was obtained as a white solid.

Molecular Weight:160.17
XLogP3:1.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:159.99942873
Monoisotopic Mass:159.99942873
Topological Polar Surface Area:56.5
Heavy Atom Count:10
Complexity:132
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes