 Home > Encyclopedia > Gd-DTPA

Gd-DTPA

Gd-DTPA structure

CAS No:
80529-93-7
Formula:
C14H18GdN3O10.2H
Chemical Name:
Gd-DTPA
Synonyms:
Gadolinate(2-),[N,N-bis[2-[bis[(carboxy-κO)methyl]amino-κN]ethyl]glycinato(5-)-κN,κO]-,hydrogen (1:2);Gadolinate(2-),[N,N-bis[2-[bis(carboxymethyl)amino]ethyl]glycinato(5-)]-,dihydrogen;Gadolinate(2-),[N,N-bis[2-[bis[(carboxy-κO)methyl]amino-κN]ethyl]glycinato(5-)-κN,κO]-,dihydrogen;Glycine,N,N-bis[2-[bis(carboxymethyl)amino]ethyl]-,gadolinium complex;Gadopentetic acid;(Diethylenetriaminepentaacetato)gadolinium;Gd-DTPA;104676-51-9;105332-91-0;106228-95-9;109998-45-0;113427-21-7;94552-93-9
Categories:
Active Pharmaceutical Ingredients > Diagnostic Agents

Description

Gadopentetic acid (Gd-DTPA) is an paramagnetic contrast agent commonly implemented by a bolus intravenous injection (i.v.) in Dynamic contrast-enhanced MRI (DCE-MRI) studies. The initial concentration of Gadopentetic acid (Gd-DTPA) in the plasma ([Gd-DTPA0]) is an important parameter for DCE-MRI. [Gd-DTPA0] is related to the administered bolus dose and varies with subjects. A bolus of 0.025 mmol/kg Gd-DTPA offers shorter acquisition time and less exposure of subjects, with a half-life of

Gadopentetic acid is a Paramagnetic Contrast Agent. The mechanism of action of gadopentetic acid is as a Magnetic Resonance Contrast Activity.|A complex of gadolinium with a chelating agent, diethylenetriamine penta-acetic acid (DTPA see PENTETIC ACID), that is given to enhance the image in cranial and spinal MRIs. (From Martindale, The Extra Pharmacopoeia, 30th ed, p706)

Gd-DTPA Basic Attributes

Molecular Weight：

547.57

Exact Mass：

548.03900

EC Number：

1592732-453-0

UNII：

K2I13DR72L

Characteristics

PSA：

204.71000

Melting Point：

129 °C (dec.)(lit.)

Boiling Point：

721.1ºC at 760 mmHg

Flash Point：

389.9ºC

Safety Information

wgk germany：

hazard class code：

36/37/38

safety instructions：

26-37/39

Marks：

Drug Information

MeSH：

Substances used to allow enhanced visualization of tissues. (See all compounds classified as Contrast Media.)

MeSH Entry Terms：

Diethylenetriaminepenta-acetic Acid, Gadolinium

Gd-DTPA Use and Manufacturing

Metal ion complexes widely used in MRI are used to diagnose brain tumors, central nervous system diseases, liver tumors, pituitary adenoma, multiple sclerosis and blood-brain barrier damage.

Computed Properties

Molecular Weight:547.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:13
Rotatable Bond Count:11
Exact Mass:548.03898
Monoisotopic Mass:548.03898
Topological Polar Surface Area:210
Heavy Atom Count:28
Complexity:454
Covalently-Bonded Unit Count:4
Compound Is Canonicalized:Yes

Recommended Suppliers of Gd-DTPA

ROYAL PHARM Contact Supplier

CN
4 YRS

Business licensed

Trader Supplier of additives,pharmaceutical chemicals,organic intermediate,chemical intermediates,Pharmaceutical Intermediates,catalyst,API

Gadopentetic Acid CAS No.80529-93-7

CAS No.: 80529-93-7

Grade: Pharmaceutical grade

Content: 99%

Inquiry
Shandong Airuike Chemical Co., Ltd. Contact Supplier

CN
3 YRS

Business licensed

Trader Supplier of api,Intermediates,Organic Chemistry,Inorganic Chemistry,Daily Chemicals,Cosmetic Raw Materals,CATALYST AND AUXILIARY,FLAVORS AND FRAGRANCES,Chemical Pesticides,ADDITIVE

Gadopentetate CAS 80529-93-7

CAS No.: 80529-93-7

Grade: Pharmaceutical Grade

Content: 99%

Inquiry