1-Hydroxypyrazole
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1-Hydroxypyrazole
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CAS No:
81945-73-5
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Formula:
C3H4N2O
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Chemical Name:
1-Hydroxypyrazole
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Synonyms:
1H-Pyrazole,1-hydroxy-;1-Hydroxy-1H-pyrazole;1-Hydroxypyrazole;N-Hydroxypyrazole;Pyrazol-1-ol;1H-Pyrazol-1-ol;126248-89-3;169382-96-1
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CAS No:
Safety Information
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
1-Hydroxypyrazole Use and Manufacturing
N-[6-(2-Hydroxy-2H-pyrazol-3-yl)-2, 4-dioxo-7-trifluoromethyl-l, 4-dihydro-2H-quinazolin-3-yl]-methanesulfonamide; Pyrazol-1-ol; OHHVi N O.A mixture of pyrazole (10 g, 147 mmol) and mCPBA (36.2 g, 147 mmol) in AcOEt (500 mL) was stirred at r.t. for 1O d. The solution was concentrated in vacuo to afford a yellow paste which was extracted with water (6 x 100 mL) and coned HCl (100 mL). The aqueous phase was washed with DCM (2 x 100 mL). The organic layers were combined, concentrated in vacuo and extracted with coned HCl (50 mL). The aqueous phases were combined and 115 g of trisodium phosphate dodecahydrate were added followed by NaOH until pH 10. The aqueous phase was concentrated in vacuo to a volume of 400 mL and was then extracted in continue with OCMfEt