Flosulide
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Flosulide
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CAS No:
80937-31-1
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Formula:
C16H13F2NO4S
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Chemical Name:
Flosulide
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Synonyms:
ZK-38997;CGP-28328;CGP-28238;Flosulide;N-[1-Oxo-6-(2,4-difluorophenoxy)indan-5-yl]methanesulfonamide;N-[[6-(2,4-Difluorophenoxy)-2,3-dihydro-1-oxo-1H-inden]-5-yl]methanesulfonamide
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CAS No:
Description
Flosulide is a potent and selective COX-2 inhibitor, used for the treatment for inflammatory diseases.
Characteristics
80.8
4.41130
1.506g/cm3
156 °C(Solv: ethanol (64-17-5))
446.9ºC at 760 mmHg
224.1ºC
1.62
Drug Information
Compounds or agents that combine with cyclooxygenase (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES) and thereby prevent its substrate-enzyme combination with arachidonic acid and the formation of eicosanoids, prostaglandins, and thromboxanes. (See all compounds classified as Cyclooxygenase Inhibitors.)|Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)
6-(2,4-difluorophenoxy)-5-methylsulfonylamino-1-indanone
Computed Properties
Molecular Weight:353.3
XLogP3:2.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:4
Exact Mass:353.05333539
Monoisotopic Mass:353.05333539
Topological Polar Surface Area:80.8
Heavy Atom Count:24
Complexity:579
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes