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Alpidem

Alpidem structure

CAS No:
82626-01-5
Formula:
C21H23Cl2N3O
Chemical Name:
Alpidem
Synonyms:
Imidazo[1,2-a]pyridine-3-acetamide,6-chloro-2-(4-chlorophenyl)-N,N-dipropyl-;6-Chloro-2-(4-chlorophenyl)-N,N-dipropylimidazo[1,2-a]pyridine-3-acetamide;Alpidem;SL 80.0342-00;Ananxyl;2-[6-Chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl]-N,N-dipropylacetamide
Categories:
Active Pharmaceutical Ingredients > Nervous System Drugs

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Description

White to Off-White Solid

Alpidem is a member of imidazoles.

Alpidem Basic Attributes

Molecular Weight：

404.33

Exact Mass：

404.33

UNII：

I93SC245QZ

DSSTox ID：

DTXSID8049046

Characteristics

PSA：

37.6

XLogP3：

5.49920

Appearance：

white to tan

Density：

1.24g/cm3

Melting Point：

140-141 °C

Refractive Index：

1.606

Water Solubility：

DMSO: ≥10mg/mL

Storage Conditions：

Refrigerator

Safety Information

Transport codes：

NONH for all modes of transport

Precautionary statement(s)：

P264, P270, P301+P312, P330, P501

Hazard Statements：

H302

Drug Information

MeSH：

Agents that alleviate ANXIETY, tension, and ANXIETY DISORDERS, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. ADRENERGIC BETA-ANTAGONISTS are commonly used in the symptomatic treatment of anxiety but are not included here. (See all compounds classified as Anti-Anxiety Agents.)

MeSH Entry Terms：

alpidem

Alpidem Use and Manufacturing

Methods of Manufacturing

Compound (I) can react with oxalyl chloride and di-n-propylamine to obtain apitan.

Uses

A peripheral benzodiazepine GABAA receptor ligand, a new anxiolytic

Computed Properties

Molecular Weight:404.3
XLogP3:4.8
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:7
Exact Mass:403.1218178
Monoisotopic Mass:403.1218178
Topological Polar Surface Area:37.6
Heavy Atom Count:27
Complexity:478
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Oxalyl chloride