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(±)-Methoxyphenamine

(±)-Methoxyphenamine structure

CAS No:
93-30-1
Formula:
C11H17NO
Chemical Name:
(±)-Methoxyphenamine
Synonyms:
Benzeneethanamine,2-methoxy-N,α-dimethyl-;Phenethylamine,o-methoxy-N,α-dimethyl-;2-Methoxy-N,α-dimethylbenzeneethanamine;Methoxyphenadrine;Methoxyphenamine;β-(o-Methoxyphenyl)isopropylmethylamine;1-(o-Methoxyphenyl)-2-methylaminopropane;α-(2-Methoxyphenyl)-β-methylaminopropane;Orthoxine;Ortodrinex;Ortoxine;2-Methoxy-N-methylamphetamine;Methoxyphenamin;Methoxiphenadrin;(±)-Methoxyphenamine;dl-Methoxyphenamine;2-Methoxymethamphetamine;[1-(2-Methoxyphenyl)propan-2-yl](methyl)amine;1-(2-Methoxyphenyl)-N-methylpropan-2-amine;93675-24-2
Categories:
Active Pharmaceutical Ingredients > Respiratory Drugs

Description

Solid

Methoxyphenamine is an amphetamine methylated on nitrogen and with the phenyl ring methoxylated at C-2. A beta-adrenergic receptor agonist, it is used as a bronchodilator. It has a role as a beta-adrenergic agonist and a bronchodilator agent.

(±)-Methoxyphenamine Basic Attributes

Molecular Weight：

179.25878

Exact Mass：

179.26

EC Number：

202-237-7

DSSTox ID：

DTXSID0023292

ATC Code：

R - Respiratory system

HScode：

2922299090

Characteristics

PSA：

21.26000

XLogP3：

2.23650

Appearance：

Solid

Density：

0.951

Melting Point：

<25 °C

Boiling Point：

98 °C

Flash Point：

103℃

Water Solubility：

1.309 mg/L @ 25 °C (est)

Drug Information

MeSH：

Drugs that selectively bind to and activate beta-adrenergic receptors. (See all compounds classified as Adrenergic beta-Agonists.)

MeSH Entry Terms：

1-(2-methoxyphenyl)-2-methylaminopropane

(±)-Methoxyphenamine Use and Manufacturing

Epinephrine drugs have a significant effect of bronchiectasis and smooth muscle relaxation. Along with a mild anti-histamine effect, sedation and cough suppression. It is suitable for the treatment of bronchial asthma, especially patients who are intolerant to ephedrine. Often its hydrochloride.

Computed Properties

Molecular Weight:179.26
XLogP3:2.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:179.131014166
Monoisotopic Mass:179.131014166
Topological Polar Surface Area:21.3
Heavy Atom Count:13
Complexity:138
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

This product has similar effects to ephedrine, but mainly stimulates beta-receptors and has a very weak effect on alpha-receptors. It can significantly relax bronchial smooth muscles and has a stronger antiasthmatic effect than ephedrine, but has a weaker effect on the cardiovascular system and central nervous system. In addition, it has mild antihistamine, sedative and cough center inhibition effects.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Compound Methoxyphenamine Capsules
Ingredients	Methoxyamphetamine.
Indication	Not yet clear.
Specifications	Each tablet contains 25 mg of aminophylline, 12.5 mg of methoxyphenamine hydrochloride, 7 mg of narcotine, and 2 mg of chlorpheniramine maleate
Manufacturer	Changxing Pharmaceutical Co., Ltd.

Compound Methoxyphenamine Capsules
Ingredients	Methoxyamphetamine.
Indication	Not yet clear.
Specifications	Compound
Manufacturer	Shanghai Sine Pharmaceutical Laboratories Co., Ltd.

Recommended Suppliers of (±)-Methoxyphenamine

Shaanxi Dideu Medichem Co. Ltd Contact Supplier

CN
5 YRS

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2-METHOXYPHENAMINE HCL

CAS No.: 93-30-1

Grade: Pharmaceutical Grade

Content: 99%

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