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Dimethocaine

Dimethocaine structure

CAS No:
94-15-5
Formula:
C16H26N2O2
Chemical Name:
Dimethocaine
Synonyms:
1-Propanol,2-[(diethylamino)methyl]-2-methyl-,1-(4-aminobenzoate);1-Propanol,3-(diethylamino)-2,2-dimethyl-,p-aminobenzoate (ester);1-Propanol,3-(diethylamino)-2,2-dimethyl-,4-aminobenzoate (ester);1-Propanol,3-(diethylamino)-2,2-dimethyl-,p-amino benzoate;Dimethocaine;Larocaine;NSC 68927
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

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Description

Dimethocaine is a local anesthetic with reported stimulant properties most similar to cocaine.

Dimethocaine is a benzoate ester.

Dimethocaine Basic Attributes

Molecular Weight：

278.396

Exact Mass：

278.39

UNII：

R3L4A6GOWZ

NSC Number：

68927

DSSTox ID：

DTXSID40240185

HScode：

2922499990

Characteristics

PSA：

55.6

XLogP3：

3.55

Density：

1.0±0.1 g/cm3

Melting Point：

53.0 to 57.0 °C

Boiling Point：

403.5±25.0 °C at 760 mmHg

Flash Point：

197.8±23.2 °C

Refractive Index：

1.529

Drug Information

MeSH：

Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate. (See all compounds classified as Anesthetics, Local.)

MeSH Entry Terms：

3-(diethylamino)-2,2-dimethylpropyl 4-aminobenzoate

Dimethocaine Use and Manufacturing

Dimethocaine is a local anesthetic with stimulatory properties that is half the potency of cocaine.

Computed Properties

Molecular Weight:278.39
XLogP3:3.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:8
Exact Mass:278.199428076
Monoisotopic Mass:278.199428076
Topological Polar Surface Area:55.6
Heavy Atom Count:20
Complexity:293
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes