Tetramethylthiuram monosulfide

208.37

208.37

1775650

202-605-7

01W430XXSQ

4767|3400

DTXSID0021333

Yellow powder

3812100000

95.96000

0.87

Yellow Powder

1.37 g/cm³ @ Temp: 20 °C

109.5 °C

260.9±23.0 °C at 760 mmHg

156 °C

1.641

H2O: insoluble

Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Peritoneal-rat LD50: 383 mg/kg; oral-mouse LD50: 818 mg/kg

Flammable; heated to decompose toxic nitrogen oxides, sulfur oxides fumes

Odorless

III

9

UN 3077 9/PG 3

3

22-43-51/53

24-26-37-61

WQ1750000

Xn,N

Treasury is ventilated, low temperature and dry; stored separately from food materials

Stable under normal temperatures and pressures.

P273-P280

H302-H317-H411

Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number U401, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.

|Warning|H302: Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P272, P273, P280, P301+P312, P302+P352, P321, P330, P333+P313, P363, P391, and P501|H302+H332 (12.64%): Harmful if swallowed or if inhaled [Warning Acute toxicity, oral; acute toxicity, inhalation]|P260, P261, P264, P270, P271, P272, P273, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P314, P321, P330, P333+P313, P363, P391, and P501|Aggregated GHS information provided by 261 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|P201, P202, P260, P261, P264, P270, P271, P272, P280, P281, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P308+P313, P312, P314, P321, P330, P332+P313, P333+P313, P337+P313, P362, P363, P405, and P501

U401; A toxic waste when a discarded commercial chemical product or manufacturing chemical intermediate or an off-specification commercial chemical product or a manufacturing chemical intermediate.

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 1 lb (statutory). The toll free number of the NRC is (800) 424-8802; In the Washington D.C. metropolitan area (202) 426-2675. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).

U401; As stipulated in 40 CFR 261.33, when bis(dimethylthiocarbamoyl) sulfide, as a commercial chemical product or manufacturing chemical intermediate or an off-specification commercial chemical product or a manufacturing chemical intermediate, becomes a waste, it must be managed according to Federal and/or State hazardous waste regulations. Also defined as a hazardous waste is any residue, contaminated soil, water, or other debris resulting from the cleanup of a spill, into water or on dry land, of this waste. Generators of small quantities of this waste may qualify for partial exclusion from hazardous waste regulations (40 CFR 261.5).

highly toxic

In adult female wistar rats, pretreated by gavage with 16 or 256 uM/kg cyanamide, tetramethylthiuram disulfide (TMTD), tetramethylthiuram monosulfide (TMTM), ziram or zineb 90 min or 18 hr before admin of 2 g ethanol/kg ip, the blood acetaldehyde levels were significantly incr for 90-240 min after ethanol admin (exceptions were noted after exposure to zineb for 90 min or to low dosed cyanamide for 18 hr). After pretreatment for identical periods with ANTU or ANIT at doses extending into the LD50 range, the blood acetaldehyde levels of rats given the same dose of ethanol remained uninfluenced. The incr in blood acetaldehyde recorded after 16 uM/kg TMTM and TMTD orally remained detectable for up to 48 hr. Onset of the cyanamide action /resulted/ after 45 min. ...

Bis(dimethylthiocarbamoyl) sulfide's production and use as a vulcanization accelerator(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a recommended classification scheme(1), an estimated Koc value of 10(SRC), determined from a structure estimation method(2), indicates that bis(dimethylthiocarbamoyl) sulfide will have very high mobility in soil(SRC). Based on data for a similar compound, the disulfide (tetramethylthiuram disulfide), bis(dimethylthiocarbamoyl) sulfide is expected to be resistant to aerobic biodegradation in soil(SRC); over a 4 week period, tetramethylthiuram disulfide (at 100 mg/L, sewage inoculum) reached 2.8% of the theoretical BOD(3). Bis(dimethylthiocarbamoyl) sulfide, as a powdered additive placed onto a membrane or resin support and buried in soil, did not support microbial growth over a 3 month period(4). Volatilization of bis(dimethylthiocarbamoyl) sulfide may be important from moist soil surfaces(SRC) given an estimated Henry's Law constant of 1.7X10-5 atm-cu m/mole(5,SRC), but not from dry soil surfaces(SRC), based on an estimated vapor pressure of 2.7X10-4 mm Hg at 25 °C(6,SRC).|AQUATIC FATE: Based on a recommended classification scheme(1), an estimated Koc value of 10(SRC), determined from a structure estimation method(2), indicates that bis(dimethylthiocarbamoyl) sulfide will not adsorb to suspended solids and sediment(SRC) in the water. Based on data for a similar compound, the disulfide (tetramethylthiuram disulfide), bis(dimethylthiocarbamoyl) sulfide is expected to be resistant to aerobic biodegradation(SRC); over a 4 week period, tetramethylthiuram disulfide (at 100 mg/L, sewage inoculum) reached 2.8% of the theoretical BOD(3). Bis(dimethylthiocarbamoyl) sulfide may volatilize from water surfaces based on an estimated Henry's Law constant of 1.7X10-5 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). Estimated half-lives for a model river and model lake are 3 and 28 days, respectively(5,SRC). An estimated BCF value of 2(5,SRC), from an estimated log Kow(6,SRC), suggests that bioconcentration in aquatic organisms is low(SRC), according to a recommended classification scheme(7).|ATMOSPHERIC FATE: According to a suggested classification scheme(1), an estimated vapor pressure of 2.7X10-4 mm Hg at 25 °C(2,SRC) indicates that bis(dimethylthiocarbamoyl) sulfide will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase bis(dimethylthiocarbamoyl) sulfide is degraded in the atmosphere by reaction with photochemically produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be about 3 hours(3,SRC). Particulate-phase bis(dimethylthiocarbamoyl) sulfide may be physically removed from the air by wet and dry deposition(SRC).

The rate constant for the vapor-phase reaction of bis(dimethylthiocarbamoyl) sulfide with photochemically produced hydroxyl radicals has been estimated as 1.4X10-10 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1,SRC). This corresponds to an atmospheric half-life of about 3 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1,SRC).

An estimated BCF value of 2 was calculated for bis(dimethylthiocarbamoyl) sulfide(SRC), using an estimated log Kow of 0.75(1,SRC) and a recommended regression-derived equation(2). According to a classification scheme(3), this BCF value suggests that bioconcentration in aquatic organisms is low(SRC). A similar compound, the disulfide (tetramethylthiuram disulfide), had measured BCF values of 1.1-4.4 in carp(4).

Using a structure estimation method based on molecular connectivity indexes(1), the Koc for bis(dimethylthiocarbamoyl) sulfide can be estimated to be about 10(SRC). According to a recommended classification scheme(2), this estimated Koc value suggests that bis(dimethylthiocarbamoyl) sulfide has very high mobility in soil(SRC).

The Henry's Law constant for bis(dimethylthiocarbamoyl) sulfide is estimated as 1.7X10-5 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This value indicates that bis(dimethylthiocarbamoyl) sulfide will volatilize from water surfaces(2,SRC). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec) is estimated as approximately 3 days(2,SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec) is estimated as approximately 28 days(2,SRC). Bis(dimethylthiocarbamoyl) sulfide's estimated value for vapor pressure, 2.7X10-4 mm Hg(3,SRC) indicates that volatilization from dry soil surfaces will not be a major fate process(SRC); its estimated Henry's Law constant(1,SRC) suggests that volatilization from moist soil surfaces may occur(SRC).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 33,447 workers (2904 of these are female) are potentially exposed to bis(dimethylthiocarbamoyl) sulfide in the USA(1). Bis(dimethylthiocarbamoyl) sulfide and tetramethylthiuramdisulphide (not separated) were released from 2 of 5 surgical gloves (concentrations of 1.8-4.0 mg/200 mL sweat) and 1 of 5 household gloves (at 0.1 mg/200 mL sweat) after exposure to synthetic sweat for 20 hours(2).

1. LAVAGE STOMACH WITH TAP WATER. ... 2. AVOID FATS, OILS, & LIPID SOLVENTS, WHICH ENHANCE ABSORPTION. 3. RIGOROUSLY PROHIBIT ALL FORMS OF ALCOHOL FOR @ LEAST 10 DAYS. 4. ARTIFICIAL RESP & OXYGEN THERAPY AS NEEDED. /THIRAM/|5. SYMPTOMATIC & SUPPORTIVE TREATMENT FOR VARIOUS GASTROINTESTINAL SYMPTOMS & NEUROLOGICAL COMPLICATIONS. /THIRAM/

IN RUBBER INDUSTRY, NUMBER OF CHEMICAL AGENTS USED IN PREPARING RUBBER CAN SENSITIZE EXPOSED WORKERS... THESE INCL ACCELERATORS SUCH AS...TETRAMETHYLTHIURAM MONOSULFIDE...|...ALLERGIC CONTACT DERMATITIS... /RUBBER ACCELERATORS/|SYMPTOMATOLOGY (THE ALCOHOL-INDUCED REACTION ONLY): 1. SENSATION OF HEAT, FLUSHING, VASODILATATION. 2. FALL IN BLOOD PRESSURE, TACHYCARDIA, PALPITATIONS. 3. SEVERE PULSATING HEADACHE, NAUSEA & VOMITING. 4. DYSPNEA, SENSATION OF CONSTRICTION IN THE NECK, CHEST PAIN.|SYMPTOMATOLOGY: 5. HYPOTENSION, SWEATING, THIRST, WEAKNESS, VERTIGO & CONFUSION. ...VISUAL HALLUCINATIONS... 6. CIRCULATORY COLLAPSE, COMA, & DEATH. 7. SEVERE ATYPICAL REACTIONS...MYOCARDIAL INFARCTION, ACUTE CONGESTIVE HEART FAILURE, CARDIAC ARRHYTHMIAS, MARKED RESP DEPRESSION & CONVULSIONS.|For more Human Toxicity Excerpts (Complete) data for BIS(DIMETHYLTHIOCARBAMOYL) SULFIDE (9 total), please visit the HSDB record page.

tetramethylthiuram monosulfide

ESSENTIALLY 100% AS AN ACCELERATOR FOR RUBBER VULCANIZATION

Powder and granular forms.

Rubber product manufacturing|Thiodicarbonic diamide ([(H2N)C(S)]2S), N,N,N',N'-tetramethyl-: ACTIVE

THIN-LAYER CHROMATOGRAPHY. HYLIN, JW, BULL ENVIRON CONT TOXICOL 1, 77 (1966).|Bis(dimethylthiocarbamoyl) sulfide was measured in synthetic sweat using capillary GC/MS analysis.