 Home > Encyclopedia > Fibric acid

Fibric acid

Fibric acid structure

CAS No:
943-45-3
Formula:
C10H12O3
Chemical Name:
Fibric acid
Synonyms:
Propanoic acid,2-methyl-2-phenoxy-;Propionic acid,2-methyl-2-phenoxy-;2-Methyl-2-phenoxypropanoic acid;Phenoxy-α-isobutyric acid;2-Phenoxy-2-methylpropionic acid;Phenoxyisobutyric acid;2-Phenoxyisobutyric acid;2,2-Dimethylphenoxyacetic acid;2,2-Dimethyl-2-phenoxyacetic acid;Fibric acid;NSC 34010;2-Phenoxy-2,2-dimethyl acetic acid;19128-87-1;19128-86-0
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Request for Quotation

Fibric acid Basic Attributes

Molecular Weight：

180.2

Exact Mass：

180.20

EC Number：

213-402-8

UNII：

6848ST447Q

NSC Number：

34010

DSSTox ID：

DTXSID40241410

HScode：

2918990090

Characteristics

PSA：

46.5

XLogP3：

1.9

Density：

1.1±0.1 g/cm3

Melting Point：

97-98 °C @ Solvent: Ligroine

Boiling Point：

289.3°C at 760 mmHg

Flash Point：

111.7±13.3 °C

Refractive Index：

1.526

Safety Information

Marks：

Xi: Irritant;

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 5 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

2-phenoxy-2-methylpropionic acid

Fibric acid Use and Manufacturing

To a solution of ethyl 2-methyl-2-phenoxypropanoate (2.0 g, 9.6 mmol) in EtOH (16 ml) was added a solution of NaOH (0.46 g, 11.5 mmol) in H[0270] Step 1: 2-Methyl-2-phenoxypropionic acid 6 was prepared following the procedure of Corey et al., J. Am. Chem. Soc. 1969;91 :4782. To an ice-cold, stirred suspension of powdered NaOH (3.2 g, 80 mmol) in acetone (40 mL) was added phenol (1.88 g, 20 mmol) followed by 1, 1, 1-trichloro-2-methyl-2-propanol hydrate (7.82 g, 40 mmol). The mixture was stirred at 0° C. for 2 hours and then at room temperature for 2 hours. The mixture was diluted with H2O, acidified with 2N HCl, and extracted with EtOAc. The organic layer was washed with 2 N HCl, then extracted with saturated NaHCO3 (2.x.). The aqueous extracts were combined, washed once with EtOAc, acidified with 2N HCl, then extracted with EtOAc (2.x.). The combined organic layers were washed once with saturated NaCl, dried (MgSO4), and concentrated under reduced pressure. Purification by flash chromatography gave 6 (1.36 g, 38percent): 1H NMR (300 MHz, CDCl3) δ 7.28 (t, J=8 Hz, 2H), 7.08 (t, J=8 Hz, 1H), 6.96 (d, J=8 Hz, 2H), 1.52 (s, 6H).in 100mL flask four raw benzoic acid 1. 000g (10. 63mmol), 40mL (544mmol) of acetone and sodium hydroxide 4. 256g (106. 3mmol), connect the device, insert a thermometer, stirring, reaction white turbid liquid, the temperature at about 20 ° C was added dropwise chloroform 9. 3mL (115. 54mmol), 10min dropping was completed, the reaction solution was gradually heated until boiling, then gradually cooling, 3h after TLC showed disappearance of starting material spot , and concentrated under reduced pressure to obtain yellow solid was added 20mL7K, adjusted to pH 4, extracted with ethyl acetate, separated, dried over anhydrous Na2S04, filtered to remove the drying agent and concentrated to give a yellow oil, freezer overnight, the precipitated needle-like crystals, suction filtered, washed with petroleum ether (3mLX2), 80percent ethanol and dried to give a white solid 1. 34g.

Computed Properties

Molecular Weight:180.20
XLogP3:1.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:180.078644241
Monoisotopic Mass:180.078644241
Topological Polar Surface Area:46.5
Heavy Atom Count:13
Complexity:181
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of Fibric acid

Hangzhou KieRay Chem Co.,LTD Contact Supplier

CN
5 YRS

Business licensed Certified factory

Manufactory Supplier of fine chemicals,pharmaceutical materials

2-METHYL-2-PHENOXY-PROPIONIC ACID

CAS No.: 943-45-3

Grade: industrial Grade

Content: 98%

Inquiry
QUANHUI BIO Contact Supplier

CN
1 YR

Business licensed

Trader Supplier of API & INTERMEDIATE

2-METHYL-2-PHENOXY-PROPIONIC ACID

Unit Price: $100 /KG EXW

CAS No.: 943-45-3

Grade: Pharmaceutical Grade

Content: 99%

Inquiry
Hangzhou Chungyo Chemicals Co., Ltd. Contact Supplier

CN
3 YRS

Business licensed Certified factory

Manufactory Supplier of Dyes,Textile agent,Medical intermediate,API,Pigments,Basic Chemicals

2-Methyl-2-phenoxypropanoic acid

CAS No.: 943-45-3

Grade: pharmaceutical grade

Content: 98%

Inquiry