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Home > Encyclopedia > 4-Nitrobenzenesulfonyl chloride

4-Nitrobenzenesulfonyl chloride

4-Nitrobenzenesulfonyl chloride structure

4-Nitrobenzenesulfonyl chloride 

structure
  • CAS No:

    98-74-8

  • Formula:

    C6H4ClNO4S

  • Chemical Name:

    4-Nitrobenzenesulfonyl chloride

  • Synonyms:

    Benzenesulfonyl chloride,4-nitro-;Benzenesulfonyl chloride,p-nitro-;4-Nitrobenzenesulfonyl chloride;p-Nitrobenzenesulfonyl chloride;p-Nitrophenylsulfonyl chloride;4-Nitrophenylsulfonyl chloride;4-Nitrobenzenesulfonic acid chloride;Nosyl chloride;NSC 13065;NSC 9572;4-Nitrobenzene-1-sulfonyl chloride;4-Nitrophenyl-1-sulfonyl chloride;p-Nosyl chloride;1623050-71-4

  • Categories:

    Organic Chemistry  >  Hydrocarbons and Derivatives

Description

yellow to brown powder

4-Nitrobenzenesulfonyl chloride Basic Attributes

221.62

221.62

746543

202-697-9

13065|9572

DTXSID4059178

29049085

Characteristics

88.3

2.19

yellow Powder

1.6±0.1 g/cm3

78 °C

108-110 °C @ Press: 2 x 10-4 Torr

143-144°C/1.5mm

1.588

H2O: Insoluble

Store below +30°C.

Safety Information

II

8

UN 3261 8/PG 2

3

34-52/53

26-36/37/39-45-61

C

Corrosive/Moisture Sensitive

P280-P305 + P351 + P338-P310

H314

|Danger|H314 (98.44%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]|P260, P261, P264, P272, P280, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P321, P333+P313, P363, P405, and P501|Aggregated GHS information provided by 65 companies from 12 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

4-nitrobenzenesulfonyl chloride

4-Nitrobenzenesulfonyl chloride Use and Manufacturing

Methods of Manufacturing

Mix 60g of 4, 4'-dinitrodiphenyl disulfide, 300ml of concentrated hydrochloric acid and 60ml of concentrated nitric acid, heat to 80°C, and react with chlorine gas. After the reaction was completed, the generated sulfonyl chloride was decanted and washed with water at 80°C to obtain a crude product, which was recrystallized from glacial acetic acid to obtain 72g of p-nitrobenzenesulfonyl chloride.

Uses

4-Nitrobenzenesulfonyl Chloride is used in the preparation of N-Nosyl-α-amino acid for peptide synthesis.

Benzenesulfonyl chloride, 4-nitro-: ACTIVE

Computed Properties

Molecular Weight:221.62
XLogP3:2.1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:220.9549565
Monoisotopic Mass:220.9549565
Topological Polar Surface Area:88.3
Heavy Atom Count:13
Complexity:283
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Nitric acid

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