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Noscapine hydrochloride

Noscapine hydrochloride structure

CAS No:
912-60-7
Formula:
C22H23NO7.ClH
Chemical Name:
Noscapine hydrochloride
Synonyms:
1(3H)-Isobenzofuranone,6,7-dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-,hydrochloride (1:1),(3S)-;Narcotine,hydrochloride;1(3H)-Isobenzofuranone,6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-,hydrochloride,[S-(R*,S*)]-;1(3H)-Isobenzofuranone,6,7-dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-,hydrochloride,(3S)-;1,3-Dioxolo[4,5-g]isoquinoline,1(3H)-isobenzofuranone deriv.;l-Narcotine hydrochloride;Noscapine hydrochloride;Opianine hydrochloride;11035-01-1
Categories:
Active Pharmaceutical Ingredients > Respiratory Drugs

Description

White or almost white, crystalline powder or colourless crystals, hygroscopic.

Noscapine Hydrochloride is the orally available hydrochloride salt of the opioid agonist noscapine, a phthalideisoquinoline alkaloid derived from the opium poppy Papaver somniferum, with mild analgesic, antitussive, and potential antineoplastic activities. Noscapine binds to tubulin and alters its conformation, resulting in a disruption of the dynamics of microtubule assembly (by increasing the time that microtubules spend idle in a paused state) and subsequently, the inhibition of mitosis and tumor cell death. Unlike other tubulin inhibitors such as the taxanes and vinca alkaloids, noscapine does not affect microtubule polymerization.|A naturally occurring opium alkaloid that is a centrally acting antitussive agent.

Noscapine hydrochloride Basic Attributes

Molecular Weight：

449.88

Exact Mass：

449.124115

EC Number：

213-014-9

DSSTox ID：

DTXSID6073239

NCI Thesaurus Code：

C61103

Characteristics

PSA：

75.69000

XLogP3：

3.62170

Density：

1.332g/cm3

Melting Point：

190-191 °C

Boiling Point：

565.3ºC at 760mmHg

Flash Point：

295.7ºC

Storage Conditions：

2-8°C

Toxicity：

cyt-ham:fbr 60 mg/L ESKHA5 96,55,78

Safety Information

Packing level：

III

Hazard category：

6.1(b)

Transport codes：

1544

wgk germany：

hazard class code：

safety instructions：

RTECS Number：

NP7225000

Marks：

Xn,Xi

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (97.92%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 48 companies from 4 notifications to the ECHA C&L Inventory.|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Drug Information

MeSH：

Agents that suppress cough. They act centrally on the medullary cough center. EXPECTORANTS, also used in the treatment of cough, act locally. (See all compounds classified as Antitussive Agents.)

MeSH Entry Terms：

Capval

Noscapine hydrochloride Use and Manufacturing

Anti-Tussive

Computed Properties

Molecular Weight:449.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:4
Exact Mass:449.1241298
Monoisotopic Mass:449.1241298
Topological Polar Surface Area:76.9
Heavy Atom Count:31
Complexity:647
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

This product is a peripheral antitussive drug that can suppress cough caused by lung stretch reflex. The antitussive effect generally lasts for 4 hours. There is no tolerance or dependence.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Narcotic syrup
Indication	1. It should not be used with other central nervous system stimulants. 2. If used with other drugs at the same time, drug interactions may occur. Please consult your doctor or pharmacist for details.
Specifications	100ml
Manufacturer	NORTHEAST Pharmaceutical Group Shenyang NO.1 Pharmaceutical Co., Ltd.

Compound Methoxyphenamine Capsules
Ingredients	It mainly contains four ingredients: methoxyphenamine hydrochloride, aminophylline, narcotine, and chlorpheniramine maleate.
Indication	Do not use in combination with other cough suppressants, expectorants, cold medicines, antihistamines, sedatives, etc.
Specifications	Methoxyphenamine hydrochloride 12.5 mg, Noscapine 7 mg, Aminophylline 25 mg, Chlorpheniramine maleate 2 mg
Manufacturer	Daiichi Sankyo Pharmaceutical (SHANGHAI) Co., Ltd.

Nacotine
Manufacturer	Qinghai Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

SpecGx LLC

United States
Active
China CHINO PHARMA Ltd

China
Active
Guangdong Leawell Pharmaceutical Co., Ltd.

China
Active

See More Registered Holders

Recommended Suppliers of Noscapine hydrochloride

Shaanxi Dideu Medichem Co. Ltd Contact Supplier

CN
4 YRS

Business licensed Certified factory

Manufactory Supplier of Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst,Chemical Materials,Chem&Pharm Intermediates,Organic Intermediates,Feed Additive

NOSCAPINEHYDROCHLORIDE

CAS No.: 912-60-7

Grade: Pharmaceutical Grade

Content: 99%

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