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Betamethasone acetate

Betamethasone acetate structure

CAS No:
987-24-6
Formula:
C24H31FO6
Chemical Name:
Betamethasone acetate
Synonyms:
Pregna-1,4-diene-3,20-dione,21-(acetyloxy)-9-fluoro-11,17-dihydroxy-16-methyl-,(11β,16β)-;Pregna-1,4-diene-3,20-dione,9-fluoro-11β,17,21-trihydroxy-16β-methyl-,21-acetate;(11β,16β)-21-(Acetyloxy)-9-fluoro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione;21-Acetoxy-9α-fluoro-11β,17α-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione;Betamethasone acetate;Betamethasone 21-acetate;9-Fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 21-acetate
Categories:
Active Pharmaceutical Ingredients > Hormones and the Endocrine System

Description

White Solid

Betamethasone acetate is an acetate ester, a steroid ester, a fluorinated steroid, a 17alpha-hydroxy steroid, a 20-oxo steroid, an 11beta-hydroxy steroid, a 3-oxo-Delta(1),Delta(4)-steroid and a tertiary alpha-hydroxy ketone. It derives from a betamethasone.

Betamethasone acetate Basic Attributes

Molecular Weight：

434.5

Exact Mass：

434.50

EC Number：

213-578-6

UNII：

TI05AO53L7

DSSTox ID：

DTXSID8022668

ATC Code：

QS02CA90

HScode：

2937220000

Characteristics

PSA：

100.90000

XLogP3：

2.96

Density：

1.3±0.1 g/cm3

Melting Point：

232 °C

Boiling Point：

579.4±50.0 °C at 760 mmHg

Flash Point：

304.2±30.1 °C

Refractive Index：

1.571

Water Solubility：

30mg/L(25 ºC)

Storage Conditions：

Refrigerator

Specific rotation：

D +140° (chloroform)

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

safety instructions：

22-36

Marks：

Precautionary statement(s)：

P280

Hazard Statements：

H351

GHS Classification：

|Danger|H317 (12.22%): May cause an allergic skin reaction [Warning Sensitization, Skin]|P201, P202, P260, P261, P264, P270, P271, P272, P273, P280, P281, P284, P302+P352, P304+P340, P308+P313, P310, P311, P314, P320, P321, P333+P313, P363, P391, P403+P233, P405, and P501|Aggregated GHS information provided by 90 companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

Drug Indication：

Treatment of acute otitis externa.

Drug Transformations：

Betamethasone-21-acetate has known transformation products that include Betamethasone.

MeSH：

Substances that reduce or suppress INFLAMMATION. (See all compounds classified as Anti-Inflammatory Agents.)|A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system. (See all compounds classified as Glucocorticoids.)

MeSH Entry Terms：

betamethasone acetate

Betamethasone acetate Use and Manufacturing

Uses

Betamethasone acetate (BA)

Use Classification：

Veterinary drugs -> Osurnia -> EMA Drug Category|Corticosteroids and antiinfectives in combination -> Veterinary pharmacotherapeutic group|Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients|Pharmaceuticals -> Transformation products

Computed Properties

Molecular Weight:434.5
XLogP3:2.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:4
Exact Mass:434.21046687
Monoisotopic Mass:434.21046687
Topological Polar Surface Area:101
Heavy Atom Count:31
Complexity:910
Defined Atom Stereocenter Count:8
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Extract from the above information

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Betamethasone acetate
Manufacturer	Shanghai New Hualian Pharmaceutical Co., Ltd.

Betamethasone acetate
Manufacturer	Shanghai New Hualian Pharmaceutical Co., Ltd.

Registered Holders

HOVIONE FARMACIENCIA SA

United States
Active
TAPI NL B.V.

France
Active
Shanghai New Hualian Pharmaceutical Co., Ltd.

China
Active

See More Registered Holders

Recommended Suppliers of Betamethasone acetate

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

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Betamethasone 21-acetate

CAS No.: 987-24-6

Content: 99.00%

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Henan Lihao Chem Plant Limited Contact Supplier

CN
5 YRS

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High purity Betamethasone 21-acetate 99% high quality see COA KANBEI

CAS No.: 987-24-6

Grade: Industrial Grade

Content: 99%

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