2-Hydroxypropyl acrylate

130.14200

130.14

213-663-8

0899

2927|1760

DTXSID0022143

Liquid|Colorless liquid

46.53000

0.09640

COLOURLESS LIQUID.

1.06 g/cm³

Freezing point: -30 deg C

225 °C

79.9ºC

1.442

Solubility in water, g/100ml at 25°C: 100 (good)

Keep tightly closed.

0.17 mm Hg at 25 deg C (est)

Relative vapour density (air = 1): 4.5

Class IIIA Combustible Liquid: Fl.P. at or above 140°F and below 200°F.

Explosive limits , vol% in air: 1.4-?

Henry's Law constant = 1.7X10-9 atm-cu m/mol at 25 °C (est)

When heated to decomposition it emits acrid smoke and fumes.|Freezing point: -30 °C|Hydroxyl radical reaction rate constant = 1.97X10-11 cu cm/molecule-sec at 25 °C (est)

Lower 1.4 at 212 °F (100 °C)|Class IIIA Combustible Liquid: Fl.P. at or above 140°F and below 200°F.

II

8

2927

R23/24/25

S26-S36/37/39-S45

AT1925000

T

Separated from food and feedstuffs. Cool. Keep in the dark. Store only if stabilized. See Notes. Provision to contain effluent from fire extinguishing. Store in an area without drain or sewer access.

Stable under recommended storage conditions.

P260, P261, P264, P270, P271, P272, P280, P301+P310, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P311, P312, P321, P322, P330, P333+P313, P361, P363, P403+P233, P405, P501

H301

SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.|SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.|Product: This combustible material may be burned in a chemical incinerator equipped with an afterburner and scrubber. Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Contaminated packaging: Dispose of as unused product.

Water [Note: Can become unstable at high temperatures & pressures or may react with water with some release of energy, but not violently.]

Combustible. Gives off irritating or toxic fumes (or gases) in a fire. Above 65 °C explosive vapour/air mixtures may be formed.|Corrosives, Flammable - 2nd degree

|Danger|H301+H311+H331 (12.75%): Toxic if swallowed, in contact with skin or if inhaled [Danger Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]|P260, P261, P264, P270, P271, P272, P280, P301+P310, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P311, P312, P321, P322, P330, P333+P313, P361, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 298 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H301: Toxic if swallowed [Danger Acute toxicity, oral]|H227: Combustible liquid [Warning Flammable liquids]|P210, P260, P261, P262, P264, P270, P271, P272, P273, P280, P301+P310, P301+P330+P331, P302+P350, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P311, P321, P322, P330, P333+P313, P361, P363, P370+P378, P391, P403+P233, P403+P235, P405, and P501|H302: Harmful if swallowed [Warning Acute toxicity, oral]|P260, P261, P262, P264, P270, P271, P272, P273, P280, P301+P312, P301+P330+P331, P302+P350, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P312, P314, P321, P322, P330, P333+P313, P361, P363, P403+P233, P405, and P501|P260, P261, P262, P264, P270, P272, P280, P301+P312, P301+P330+P331, P302+P350, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P309+P311, P310, P314, P321, P322, P330, P333+P313, P361, P363, P405, and P501

Personnel protection: Wear appropriate chemical protective gloves, boots, and goggles. If contact with the material anticipated, wear appropriate chemical protective clothing.|Wear appropriate eye protection to prevent eye contact.|Wear appropriate personal protective clothing to prevent skin contact.|Eyewash fountains should be provided in areas where there is any possibility that workers could be exposed to the substances; this is irrespective of the recommendation involving the wearing of eye protection.|For more Personal Protective Equipment (PPE) (Complete) data for 2-Hydroxypropyl acrylate (9 total), please visit the HSDB record page.|(See protection codes)

If the polymerization takes place inside the container, the container is subject to violent rupture.|Explosive limits , vol% in air: 1.4-?

Extinguishing methods: Alcohol foam|If material on fire or involved in fire: Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use "alcohol" foam, dry chemical, or carbon dioxide. Use water spray to knock-down vapors.|Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Advice for firefighters: Wear self-contained breathing apparatus for firefighting if necessary. Further information: Use water spray to cool unopened containers.

It is ... flammable.

ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Wear respiratory protection. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up: Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations. Keep in suitable, closed containers for disposal.

Avoid contact with skin and eyes. Avoid inhalation of vapor or mist. Keep away from sources of ignition - No smoking. Take measures to prevent the build up of electrostatic charge.|ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Wear respiratory protection. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.|Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.|Personnel protection: Avoid breathing vapors. Keep upwind. Avoid bodily contact with the material. Do not handle broken packages unless wearing appropriate personal protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap and water.|For more Preventive Measures (Complete) data for 2-Hydroxypropyl acrylate (8 total), please visit the HSDB record page.

Rats inhaling saturated HPA vapor generated at room temperature for 7 to 8 hours survived, but those exposed for 4 hours at approximately 650 ppm HPA vapor (generated at 100 °C) died either during exposure or within 1 hour after cessation of exposure. Marked signs of eye, nasal, and respiratory irritation were noted during the exposure period.|Instillation of 0.1 mL in rabbit eye produced prompt, severe ocular irritation and corneal injury.

Recommended Exposure Limit: 10 hr Time-Weighted Avg: 0.5 ppm (3 mg/cu m). Skin designation.

Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking liquid in covered containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

Separated from food and feedstuffs. Cool. Keep in the dark. Store only if stabilized. Provision to contain effluent from fire extinguishing. Store in an area without drain or sewer access.

A harmful contamination of the air will be reached rather slowly on evaporation of this substance at 20 °C.

The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation may cause lung oedema, but only after initial corrosive effects on eyes and/or airways have become manifest. If swallowed the substance may cause vomiting and could result in aspiration pneumonitis.

Repeated or prolonged contact with skin may cause dermatitis. Repeated or prolonged contact may cause skin sensitization.

NO open flames. Above 65 °C use a closed system and ventilation.

AVOID ALL CONTACT! PREVENT GENERATION OF MISTS!

Use ventilation, local exhaust or breathing protection.

Protective gloves. Protective clothing.

Wear face shield or eye protection in combination with breathing protection.

| 3 - Materials that, under emergency conditions, can cause serious or permanent injury.| 1 - Materials that must be preheated before ignition can occur. Materials require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur.| 2 - Materials that readily undergo violent chemical changes at elevated temperatures and pressures.

IDENTIFICATION AND USE: 2-Hydroxypropyl acrylate (HPA) is a colorless liquid. It is used in manufacture of thermosetting resins for surface coatings. HUMAN STUDIES: There are no data available. ANIMAL STUDIES: Instillation of 0.1 mL in rabbit eye produced prompt, severe ocular irritation and corneal injury. In rabbits topical HPA application causes moderate burns (even when contacted as a 10% aqueous solution). Rats inhaling saturated HPA vapor generated at room temperature for 7 to 8 hours survived, but those exposed for 4 hours at approximately 650 ppm HPA vapor (generated at 100 °C) died either during exposure or within 1 hour after cessation of exposure. Marked signs of eye, nasal, and respiratory irritation were noted during the exposure period. When dogs were repeatedly exposed by inhalation at 5 ppm 6 hours/day, 5 days/week for a total of 20 or 21 days during a 1-month period, signs of ocular, nasal, and respiratory tract irritation were observed, and histologic testicular changes were seen in 3 of the 4 exposed animals. HPA was tested for mutagenicity in Salmonella typhimurium strains TA102 and TA2638 (with metabolic activation) and Escherichia coli strains WP2/pKM101 and WP2 uvrA/pKM101. It was found positive in the Escherichia coli strains.

LD50 Rat oral 250 mg/kg|LD50 Mouse oral 1056 mg/kg|LD50 Rabbit dermal 170-250 mg/kg body weight|LD50 Rabbit subcutaneous 160 mg/kg

2-Hydroxypropyl acrylate's production and use in the manufacture of polymers and chemical intermediates(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 1.4(SRC), determined from a structure estimation method(2), indicates that 2-hydroxypropyl acrylate is expected to have very high mobility in soil(SRC). Volatilization of 2-hydroxypropyl acrylate from moist soil surfaces is not expected(SRC) given an estimated Henry's Law constant of 1.7X10-9 atm-cu m/mole(SRC), developed using a fragment constant estimation method(2). 2-Hydroxypropyl acrylate is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 0.17 mm Hg at 25 °C(SRC), determined from a fragment constant method(2). A 83% of Theoretical BOD using activated sludge in the Japanese MITI test(3) suggests that biodegradation is an important environmental fate process in soil(SRC).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 1.4(SRC), determined from a structure estimation method(2), indicates that 2-hydroxypropyl acrylate is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 1.7X10-9 atm-cu m/mole(SRC), developed using a fragment constant estimation method(2). A hydrolysis half-life of >230 days at pH 7 for the commercial hydroxypropyl acrylate isomer mixture was reported, the hydrolysis half-life decreases with increase pH indicating that 2-hydroxypropyl acrylate may undergo slow hydrolysis under basic conditions(4). According to a classification scheme(5), an estimated BCF of 3(SRC), from its log Kow of 0.35(6) and a regression-derived equation(2), suggests the potential for bioconcentration in aquatic organisms is low. The percent Theoretical BOD of the commercial hydroxypropyl acrylate isomer mixture reached 83% after 4 weeks in the Japanese MITI test(7) and 34.9% after 4 weeks in a closed bottle test for ready biodegradability(4). These results indicate that biodegradation will be an important fate process for 2-hydroxypropyl acrylate in water(SRC).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 2-hydroxypropyl acrylate, which has an estimated vapor pressure of 0.17 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 2-hydroxypropyl acrylate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals and ozone(SRC); the half-lives for these reactions in air are estimated to be 19 hours and 6.5 days(SRC), calculated from its respective rate constants of 2.0X10-11 and 1.7X10-18 cu cm/molecule-sec at 25 °C(SRC) that were derived using a structure estimation method(2). 2-Hydroxypropyl acrylate contains chromophores that absorb at wavelengths >290 nm(3) and, therefore, may be susceptible to direct photolysis by sunlight(SRC).

The rate constant for the vapor-phase reaction of 2-hydroxypropyl acrylate with photochemically-produced hydroxyl radicals has been estimated as 2.0X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 20 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). The rate constant for the vapor-phase reaction of 2-hydroxypropyl acrylate with ozone has been estimated as 1.7X10-18 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(1). This corresponds to an atmospheric half-life of about 6.5 days at an atmospheric concentration of 7X10+11 ozone molecules per cu cm(2). A base-catalyzed second-order hydrolysis rate constant of 0.024 L/mole-sec(SRC) was estimated using a structure estimation method(1); this corresponds to half-lives of 9 and 0.9 years at pH values of 7 and 8, respectively(1). Hydrolysis half-lives of >490, >230 and 0.056 days were reported at respective pH values of 2.85, 7.03 and 10.9 for a commercial hydroxypropyl acrylate isomer mixture(3). 2-Hydroxypropyl acrylate contains chromophores that absorb at wavelengths >290 nm(4) and, therefore, may be susceptible to direct photolysis by sunlight(SRC).

An estimated BCF of 3 was calculated in fish for 2-hydroxypropyl acrylate(SRC), using a log Kow of 0.35(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low.

Using a structure estimation method based on molecular connectivity indices(1), the Koc of 2-hydroxypropyl acrylate can be estimated to be 1.4(SRC). According to a classification scheme(2), this estimated Koc value suggests that 2-hydroxypropyl acrylate is expected to have very high mobility in soil.

The Henry's Law constant for 2-hydroxypropyl acrylate is estimated as 1.7X10-9 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that 2-hydroxypropyl acrylate is expected to be essentially nonvolatile from water and moist soil surfaces(2). 2-Hydroxypropyl acrylate is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 0.17 mm Hg(SRC), determined from a fragment constant method(1).

Occupational exposure to 2-hydroxypropyl acrylate may occur through inhalation and dermal contact with this compound at workplaces where 2-hydroxypropyl acrylate is produced or used. The general population is not likely to be exposed to 2-hydroxypropyl acrylate. (SRC)

The goal of these studies was to measure and interpret the skin permeability characteristics of 2-hydroxypropyl acrylate (HPA) as a model compound that is completely miscible with water. METHODS: In vitro permeation from HPA-H2O binary mixtures through human epidermis and silicone membranes was measured. Thermodynamic activities of HPA and H2O in these mixtures were determined. Permeation was also measured through epidermis and silicone from donor solutions with constant HPA activity but different H2O activities. Water uptake into desiccated human stratum corneum (SC) equilibrated with HPA-H2O mixtures was determined. RESULTS: Steady-state flux of HPA through silicone was a linear function of HPA activity but not HPA concentration. For epidermis on the other hand, flux increased with HPA activity only for HPA activities = 0.35. At constant HPA activity, flux decreased 4.5-fold as water activity decreased from 1 to 0.8. Incubation of SC with HPA-H2O mixtures resulted in substantial changes in SC water content, dependent on the water activity of the mixture and consistent with measured SC water sorption data. CONCLUSIONS: These experiments provide unequivocal evidence of a substantial increase in epidermal barrier function resulting from SC dehydration. Dehydration-related alterations in the SC appear responsible for the observed flux characteristics.

(See procedures)

Fresh air, rest. Half-upright position. Refer immediately for medical attention.

Remove contaminated clothes. Rinse skin with plenty of water or shower for at least 15 minutes. Refer immediately for medical attention.

Rinse with plenty of water (remove contact lenses if easily possible). Refer immediately for medical attention.

/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Organic acids and related compounds/|/SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist respirations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Activated charcoal is not effective ... . Do not attempt to neutralize, because of exothermic reaction. Cover skin burns with dry, sterile dressings after decontamination ... . /Organic acids and related compounds/|/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Early intubation, at the first sign of upper airway obstruction, may be necessary. Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Organic acids and related compounds/

2-hydroxypropyl acrylate

The substance can be absorbed into the body through the skin and by ingestion. Serious local effects by all routes of exposure.|inhalation, skin absorption, ingestion, skin and/or eye contact

irritation eyes, skin, respiratory system; eye, skin burns; cough, dyspnea (breathing difficulty)

Cough. Sore throat. Burning sensation. Shortness of breath. Laboured breathing.

MAY BE ABSORBED! Redness. Pain. Skin burns. Blisters.

Redness. Pain. Blurred vision. Severe deep burns.

Eyes, skin, respiratory system

/Hydroxypropyl acrylate (CAS No 25584-83-2) / as the commercial product /that is/ routinely produced ... contains approximately 75-80% 2-hydroxypropyl acrylate (CAS No 999-61-1) and 20-25% 1-methyl-2-hydroxyethyl acrylate (CAS No 2918-23-2)

Hydroxyethyl and 2-hydroxypropyl acrylates are prepared by the addition of ethylene oxide or propylene oxide to acrylic acid. The reactions are catalyzed by tertiary amines, quaternary ammonium salts, metal salts, and basic ion-exchange resins. The products are difficult to purify and generally contain low concentrations of acrylic acid and some diester which should be kept to a minimum since its presence leads to product instability and to polymer cross-linking.

Method: OSHA PV2078; Procedure: gas chromatography using a flame ionization detector; Analyte: 2-hydroxypropylacrylate; Matrix: air; Detection Limit: 0.045 ppm (0.240 mg/cu m).

Fire Hazards -> Corrosives, Flammable - 2nd degree