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Polyethylene glycol monomethyl ether

Polyethylene glycol monomethyl ether structure

CAS No:
9004-74-4
Formula:
(C2H4O)nCH4O
Chemical Name:
Polyethylene glycol monomethyl ether
Synonyms:
Poly(oxy-1,2-ethanediyl),α-methyl-ω-hydroxy-;Glycols,polyethylene,monomethyl ether;Polyethylene glycol monomethyl ether;Carbowax 350;Polyethylene glycol methyl ether;Ethylene oxide-methanol adduct;α-Methyl-ω-hydroxypoly(oxy-1,2-ethanediyl);Methyl polyglycol;Carbowax 750;Methoxypoly(ethylene glycol);Carbowax 550;Carbowax 2000;Carbowax 5000;Monomethoxypolyethylene glycol;MPEG;MPEG 5000;Monomethoxypolyoxyethylene;Nissan Uniox M 2000;Hymol PM;MPG 025;MPG 081;Nissan Uniox M 400;O-Methoxypolyethylene glycol;Breox MPEG 550;GN 8384;CP 2000 (polyoxyalkylene);CP 2000;Monomethoxy poly(ethylene oxide);Nissan Uniox M 550;Poly(ethylene oxide) monomethyl ether;Toho Me-PEG 400;Toho Me-PEG 1000;Uniox M 400;Nissan Uniol 1000;Nissan Uniol 550;MPEG 500;Nissan Uniox M 1000;Uniox M 1000;Uniox M 2000;Carbowax 750ME;MPG 130;Uniox M 550;Polyglycol M 750;Sanfine MM 2000;MPEG 350;MPEG 2000;MPEG 10000;Nissan Uniox M 600;Carbowax MPEG 5000;Pluriol A 500E;Pluriol A 350E;Pluriol A 275E;Nissan Uniox M 4000;MPEG 950;Sunbright MEH 20T;MPG;Carbowax MPEG 450;Pluriol A 2000E;MPG 140;Pluriol A 2000;Methoxy PEG 400;Me-PEG 400;Conion MP 220;Polyoxyethylene monomethyl ether;Polyglycol M 5000S;Polyglycol M 2000S;M 550;2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50-Heptadecaoxadopentacontan-52-ol;Pluriol 350E;M 750;MPEG 750;Pluriol 500;Polyglycol M 500;Uniox M 4000;Sunbright MEH 50H;Pluriol A 750I;Marlipal 1/12;5702-16-9;12623-96-0;41396-14-9;54386-07-1;57244-93-6;64543-87-9;69592-91-2;72664-19-8;77102-87-5;86002-19-9;91826-72-1;95507-78-1;95507-80-5;102868-77-9;104841-59-0;114740-40-8;126966-17-4;134919-42-9;138753-86-3;142172-77-8;146162-92-7;154701-70-9;154885-26-4;158360-78-2;162582-19-6;163294-10-8;163733-28-6;165338-17-0;166441-82-3;178613-33-7;185250-24-2;187523-66-6;189209-93-6;193008-24-1;195970-98-0;207799-14-2;212969-32-9;216693-45-7;226212-72-2;237739-71-8;241466-57-9;396134-26-2
Categories:
Cosmetic Ingredient > Dissolving Agent

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Description

m-PEG-OH (MW 2000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Polyethylene glycol monomethyl ether Basic Attributes

Molecular Weight：

120.14698

Exact Mass：

516.314575

EC Number：

215-801-2

DSSTox ID：

DTXSID10872619

HScode：

29091990

Characteristics

PSA：

29.5

XLogP3：

-0.8

Appearance：

White to pale yellow semisolid

Density：

1.08

Melting Point：

50 °C

Boiling Point：

200-220 °C @ Press: 0.01 Torr

Flash Point：

268 °C

Refractive Index：

1.456

Water Solubility：

H2O: 50 mg/mL at 25 °C, clear, colorless

Storage Conditions：

-20°C

Vapor Pressure：

0.05 mm Hg ( 20 °C)

Vapor Density：

>1 (vs air)

Flammability characteristics：

Class II Combustible Liquid: Fl.P. at or above 100°F and below 140°F.

Explosive limit：

Explosive limits , vol% in air: 2.3-24.5

Safety Information

Packing level：

III

Hazard category：

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

60-61-10-20/21/22

safety instructions：

24/25-22

RTECS Number：

PE8271000

Marks：

Storage features：

Fireproof. Separated from strong oxidants and food and feedstuffs. Keep in the dark. Cool.

Stability/Shelf Life：

Stable. Incompatible with strong oxidizing agents, strong acids, strong bases.

Precautionary statement(s)：

P201, P202, P210, P233, P240, P241, P242, P243, P261, P264, P270, P271, P280, P281, P301+P312, P302+P352, P303+P361+P353, P304+P312, P304+P340, P308+P313, P312, P322, P330, P363, P370+P378, P403+P235, P405, P501

Hazard Statements：

H226

Polyethylene glycol monomethyl ether Use and Manufacturing

Polyethylene glycol is a polymer of ethylene oxide hydrolysate. It is non-toxic and non-irritating and is widely used in various pharmaceutical preparations. Low-molecular-weight polyethylene glycols are relatively more toxic. Taken together, glycols have relatively low toxicity. Topical application of polyethylene glycol, especially mucosal administration, can cause irritation and pain. In the topical lotion, this product can increase the flexibility of the skin and has a moisturizing effect similar to glycerin. High-dose oral polyethylene glycol can cause diarrhea. In injections, the maximum concentration of polyethylene glycol 300 is about 30% (V/V), and hemolysis may occur if the concentration is greater than 40% (V/V).

Computed Properties

Molecular Weight:560.7
XLogP3:-2.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:13
Rotatable Bond Count:35
Exact Mass:560.34079171
Monoisotopic Mass:560.34079171
Topological Polar Surface Area:131
Heavy Atom Count:38
Complexity:408
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Guide of Polyethylene glycol monomethyl ether

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Computed Properties
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Polyethylene glycol monomethyl ether

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