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Cytidine

Cytidine structure

Cytidine 

structure
  • CAS No:

    65-46-3

  • Formula:

    C9H13N3O5

  • Chemical Name:

    Cytidine

  • Synonyms:

    Cytidine;Cytosine,1-β-D-ribosyl-;Cytosine riboside;1-β-D-Ribofuranosylcytosine;β-D-Ribofuranoside,cytosine-1;1-(β-D-Ribofuranosyl)-2-oxo-4-amino-1,2-dihydro-1,3-diazine;2(1H)-Pyrimidinone,4-amino-1-β-D-ribofuranosyl-;4-Amino-1-β-D-ribofuranosyl-2(1H)-pyrimidinone;NSC 20258;β-D-Cytidine;4395-95-3;494210-74-1;873077-03-3

  • Categories:

    Cosmetic Ingredient  >  Skin Conditioning

Description

Cytidine is a nucleoside molecule that is formed when cytosine is attached to a ribose ring, cytidine is a component of RNA.Target: Nucleoside antimetabolite/analogCytidine is a nucleoside molecule that is formed when cytosine is attached to a ribose ring (also known as a ribofuranose) via a β-N1-glycosidic bond. Cytidine is a component of RNA. If cytosine is attached to a deoxyribose ring, it is known as a deoxycytidine. Dietary sources of cytidine include foods with high RNA (ribonucle


Cytidine is a white crystalline powder. (NTP, 1992)|Solid


Cytidine is a white crystalline powder. (NTP, 1992)|Cytidine is a pyrimidine nucleoside in which cytosine is attached to ribofuranose via a beta-N(1)-glycosidic bond. It has a role as a human metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and a mouse metabolite. It derives from a cytosine.|Cytidine is a pyrimidine nucleoside comprised of a cytosine bound to ribose via a beta-N1-glycosidic bond. Cytidine is a precursor for uridine. Both cytidine and uridine are utilized in RNA synthesis.|A pyrimidine nucleoside that is composed of the base CYTOSINE linked to the five-carbon sugar D-RIBOSE.

Cytidine Basic Attributes

243.22

243.22

89173

200-610-9

5CSZ8459RP

C409

2934999090

Characteristics

129

-2.1

White to almost white powder

1.9±0.1 g/cm3

230.5 °C (decomp)

545.7°C at 760 mmHg

274.1±32.9 °C

1.756

H2O: 50 mg/mL

Store at RT.

Negligible (NTP, 1992)

LD50 intraperitoneal in mouse: 2700mg/kg

31.5 º (c=0.6, H2O 25 ºC)

159.5 Ų [M+Na]+ [CCS Type: DT, Method: single field calibrated with Agilent tune mix (Agilent)]|148 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine]|151 Ų [M+H]+ [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|159.7 Ų [M+Na]+ [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|149.8 Ų [M-H]- [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|151.1 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]|150 Ų [M-H]-

This compound is hygroscopic. Water soluble.

Alcohols and Polyols

CYTIDINE is incompatible with strong oxidizing agents. (NTP, 1992). Will react as a weak base.

Safety Information

NONH for all modes of transport

3

68

24/25

UW7370000

Stable. Incompatible with strong oxidizing agents. Protect from moisture.

Flash point data for this compound are not available; however, it is probably combustible. (NTP, 1992)

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. A water spray may also be used. (NTP, 1992)

SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should store this chemical under refrigerated temperatures, protect it from moisture, and keep it away from oxidizing materials. (NTP, 1992)

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

Drug Information

SYMPTOMS: Exposure to this compound may cause irritation. ACUTE/CHRONIC HAZARDS: This chemical may be harmful by inhalation, ingestion or skin absorption. It may cause irritation. When heated to decomposition it may emit toxic fumes of carbon monoxide, carbon dioxide and nitrogen oxides. (NTP, 1992)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

Cytidine

Cytidine Use and Manufacturing

Uses

increases cell membrane phospholipids

Cytidine: ACTIVE

Computed Properties

Molecular Weight:243.22
XLogP3:-2.1
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:243.08552052
Monoisotopic Mass:243.08552052
Topological Polar Surface Area:129
Heavy Atom Count:17
Complexity:383
Defined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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