Protamine sulfate
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Protamine sulfate
structure -
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CAS No:
9009-65-8
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Chemical Name:
Protamine sulfate
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Synonyms:
Protamine sulfate;Protamines,sulfates;Protamine sulfates;Novo protamine sulfate
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CAS No:
Characteristics
-1.03
white amorphous powder
2.2±0.1 g/cm3
330.0±11.0 °C at 760 mmHg
1.537
It issparingly soluble in water.
+2C to +8C
Protamine sulfate Use and Manufacturing
Extraction, precipitation, washing, minced fish white, add 4 times the amount of water, stir for 1 hour, and filter. The pH of the filtrate was adjusted to 4.5 with glacial acetic acid, and the resulting precipitate was collected. Wash with ethanol, acetone, ether in turn, dry, ball mill into powder to obtain crude product. Green bark fish white [water]→[1h] extract [glacial acetic acid]→[pH4.5] precipitate [ethanol, acetone, ether]→ crude product acid extraction, precipitation, dissolution, precipitation, dissolve the crude crystals in 3 Stir in 3% sulfuric acid for 1.5 hours, filter, and extract the filter residue with 1.5 times the amount of 3% sulfuric acid solution for 1 hour, combine the filtrate, use 3 times the amount of 96% ethanol to precipitate the precipitate, stand overnight, and centrifuge. Dissolve the precipitate with 3 times the amount of distilled water at 80°C for half an hour. Add talc powder while it is hot and filter, and the filtrate is precipitated with 3 times the amount of 95% ethanol and filtered to obtain the precipitate. Refined products [3% sulfuric acid]→[1.5h, 2 times] filtrate [96% ethanol]→precipitate [water]→[80-85℃] filtrate [95% ethanol]→precipitate alkalization, acidification, precipitation, The dried precipitate was dissolved with 3 times the amount of distilled water, adjusted to pH 11, heated to 80°C, filtered hot, and talc was used as a filter aid. The clear liquid was collected and allowed to stand at 0°C for 24h to obtain a creamy precipitate. Dissolve the precipitate with 3 times the amount of distilled water, adjust the pH to 2.5 with 10% sulfuric acid to obtain the acidified solution, filter with a No. 4 vertical melting funnel, refrigerate the filtrate overnight, add 3 times the amount of ethanol (95%), and place for several hours to precipitate , Discard the ethanol solution. The precipitate is washed with absolute ethanol, acetone, and anhydrous ether in sequence, drained, and placed in a phosphorus pentoxide vacuum dryer to obtain protamine sulfate. Precipitate [Sodium Hydroxide]→[pH11, 80-85℃] Paste-like Precipitate [10% Sulfuric Acid]→[pH2.5] Acidification Solution [95% Ethanol]→ Precipitate [Phosphorus Pentoxide]→Fish Protamine Sulfate
This product has a strong basic group, which can combine with strong acidic heparin in the body to form a stable complex, thereby making heparin lose its anticoagulant ability. It still has a mild antithrombin prokinase effect, and it is generally not used clinically to counteract the anticoagulant effect caused by non-heparin. Because this product can be combined with some proteins and peptides, it can be used to form complexes with insulin and corticotropin to prepare long-acting injections.
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