2-Phenyl-2-propanol

136.19

136.19

210-539-5

JE030BGE05

212537|1261

DTXSID3027247

PRISMS

2906299090

20.2

1.8

Liquid

0.9735 g/cm³ @ Temp: 20 °C

36 °C

202 °C @ Press: 760 Torr

87.8±0.0 °C

1.518

Insoluble in water.

Store at 0-5ºC

Vapor pressure = 0.52 mm Hg at 37.8 deg C

CONVERSION FACTORS: 1 MG/L= 179.5 PPM @ 25 °C & 760 MM HG; 1 PPM= 5.57 MG/CU M @ 25 °C & 760 MM HG|Liquid molar volume = 0.138754 cu m/kmol (determined at the triple point)

The /process/ of corrosion was studied at several points along the flow in a biological treatment facility for phenolic waters. The waters contained phenol, sulfate, isopropylbenzene hydroperoxide, butylphenol, dimethylphenylcarbinol and other organic substances. Sulfate has been reduced by the action of Desulfovibrio desulfuricans. The rate of corrosion was assessed quantitatively using gravimetric and penetration indices, qualitatively by macroscopic observation. The rate of corrosion on carbon steel ranged from 0.04 to 0.8 g/sq m/hr where local forms of corrosion were detected. ...

1325

3

R22

S26-S36

DO4562000

Xn:Harmful;

P261-P305 + P351 + P338

H302-H315-H319-H335

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Pereira WE et al; Environ Sci Technol 16 (7): 387-96 (1982). Characterization of organic contaminants in environmental samples associated with Mount St. Helens 1980 volcanic eruption.

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P280, P301+P312, P302+P352, P305+P351+P338, P321, P330, P332+P313, P337+P313, P362, and P501|Aggregated GHS information provided by 1783 companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|Danger|H302: Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P280, P301+P312, P302+P352, P312, P322, P330, P361, P363, P405, and P501

2-Phenylisopropanol has been detected in wastewater from the organics and plastics (23 ng/ul extract) and transportation equipment (2513 ng/ul extract) industries(1). At the Northeast Sewage Treatment plant located on the Delaware River near Philadelphia, 2-phenylisopropanol was detected at 70 ppb in the inflow, at 70 ppb in the outflow, at 2 ppb 2 miles upstream, and at 0.5 ppb one mile downstream(2). 2-Phenylisopropanol has been qualitatively identified in advanced waste treatment water from Orange County, CA(3).

LD50 MOUSE ORAL 1.950 G/KG|LD50 Rats oral 1.07 ml/kg|LD50 Rabbit dermal 1.0 ml/kg

2-Phenylisopropanol's production and use as a flotation frother(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a recommended classification scheme(1), estimated Koc values of 36 to 270(SRC), determined from a structure estimation method(2), and an estimated log Kow(3,SRC) with a recommended regression-derived equation(5), indicate that 2-phenylisopropanol will have medium to very high mobility in soil(SRC). Volatilization of 2-phenylisopropanol may not be important from moist soil surfaces(SRC) given an estimated Henry's Law constant of 3.8X10-7 atm-cu m/mole(4,SRC), but may be important from dry soil surfaces(SRC) based on an estimated vapor pressure of 0.047 mm Hg at 25 °C(5,SRC) and a measured vapor pressure of 0.52 mm Hg at 37.8 °C(7). According to a Zahn-Wellens test, 2-phenylisopropanol will biodegrade readily in soil(6).|AQUATIC FATE: Based on a recommended classification scheme(1), estimated Koc values of 36 to 270(SRC), determined from a structure estimation method(2), and an estimated log Kow(3,SRC) with a recommended regression-derived equation(5), indicate that 2-phenylisopropanol has the potential to adsorb to suspended solids and sediment(SRC) in the water. 2-Phenylisopropanol should not volatilize from water surfaces based on an estimated Henry's Law constant of 3.8X10-7 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). An estimated BCF value of 18(4,SRC), from an estimated log Kow(3,SRC), suggests that 2-phenylisopropanol will not bioconcentrate in aquatic organisms(SRC) according to a recommended classification scheme(6). According to a Zahn-Wellens test, 2-phenylisopropanol will biodegrade readily in water(7). 2-Phenylisopropanol may undergo reaction with photochemically produced hydroxyl radicals in water(8) with a half-life of approximately 170 days(8,9,SRC).|ATMOSPHERIC FATE: According to a suggested classification scheme(1), an estimated vapor pressure of 0.047 mm Hg at 25 °C(2,SRC) indicates that 2-phenylisopropanol will exist in the vapor phase in the ambient atmosphere. Vapor-phase 2-phenylisopropanol is degraded in the atmosphere by reaction with photochemically produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be about 3 days(3,SRC).

The rate constant for the vapor-phase reaction of 2-phenylisopropanol with photochemically produced hydroxyl radicals has been estimated as 5.5X10-12 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1,SRC). This corresponds to an atmospheric half-life of about 3 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1,SRC). The rate constant for the reaction between photochemically produced hydroxyl radicals in water and 2-phenylisopropanol is 4.6X10+9 L/mole-sec(2); assuming that the concentration of hydroxyl radicals in brightly sunlit natural water is 1X10-17 M(3), the half-life would be about 174 days(SRC).

An estimated BCF value of 18 was calculated for 2-phenylisopropanol(SRC), using an estimated log Kow of 1.95(1,SRC) and a recommended regression-derived equation(2). According to a recommended classification scheme(3), this BCF value suggests that bioconcentration in aquatic organisms will not be an important fate process(SRC).

Using a structure estimation method based on molecular connectivity indexes(1), the Koc for 2-phenylisopropanol can be estimated to be about 36(SRC). The Koc of 2-phenylisopropanol can also be estimated to be approximately 274(SRC), using an estimated log Kow of 1.95(2,SRC) and a regression-derived equation(3,SRC). According to a recommended classification scheme(4), these estimated Koc values suggest that 2-phenylisopropanol has very high to medium mobility in soil(SRC).

The Henry's Law constant for 2-phenylisopropanol is estimated as 3.8X10-7 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This value indicates that 2-phenylisopropanol will be essentially nonvolatile from water surfaces(2,SRC). 2-Phenylisopropanol's vapor pressure, 0.047 mm Hg(3,SRC) indicates that volatilization from dry soil surfaces may occur. However, 2-phenylisopropanol's Henry's Law constant(1,SRC) indicates that volatilization from moist soil may not occur(SRC).

DRINKING WATER: 2-Phenylisopropanol has been qualitatively detected in drinking water from the Torresdale Water Treatment Plant near Philadelphia(1). 2-Phenylisopropanol has been qualitatively identified in drinking water from Miami, FL, New Orleans, LA, and Philadelphia, PA(2).|GROUND WATER: 2-Phenylisopropanol has been detected in the acidic fraction of groundwater samples taken from an aquifer contaminated with organic wastes in Australia(1). 2-Phenylisopropanol was found in two groundwater samples at the "Valley of the Drums" near Louisville, KY at 5.6 and 19 ug/l(2).|SURFACE WATER: 2-Phenylisopropanol was qualitatively identified in treated river water(1). 2-Phenylisopropanol was detected in the Delaware River near two chemical companies at a concentration of 2-3 ppb(2). 2-Phenylisopropanol was detected in water from the Hayashida River (Tatsuno City, Japan) at a concentration of 119 ppb by vacuum distillation(3). 2-Phenylisopropanol was found in standing water in which chemical drums were sitting at the "Valley of the Drums' near Louisville, KY at a concentration of 86 ug/L(4).

2-Phenylisopropanol has been qualitatively identified in corbicula(1).

Exposure to 2-phenylisopropanol can occur through dermal contact, inhalation, and ingestion(1).

DIMETHYLPHENYLCARBINOL IS A METABOLITE OF ISOPROPYLBENZENE.|The enantioselective metabolism of cumene was studied in rabbits. The major metabolites identified /in urine/ were 2-phenyl-2-propanol, (R)-(+)-2-phenyl-1-propanol, (S)-(+)-2-phenylpropanoic acid and (R)-(-)-2-hydroxy-2-phenylpropanoic acid. Based on these metabolites, two routes of cumene metabolism were /noted/.

2-phenyl-2-propanol

Adhesive manufacturing|Benzenemethanol, .alpha.,.alpha.-dimethyl-: ACTIVE

SILUFOL UF 254, AN ALUMINUM FOIL COVERED WITH SILICA GEL AND A FLUORESCENT BINDER, WAS USED TO MONITOR THE TITLE COMPOUNDS IN WASTEWATER. THE BENZENE MOBILE PHASE WAS 9:1. SPRAYING WITH 0.2% 2,4-DINITROPHENYLHYDRAZINE IN 2 M HYDROGEN CHLORIDE OR 1% P-DIMETHYLAMINOBENZALDEHYDE IN ETHYL ETHER VISUALIZED ACETOPHENONE AND OTHER COMPONENTS, RESPECTIVELY.

2-PHENYL-2-PROPANOL WAS DETERMINED IN URINE BY GAS CHROMATOGRAPHY USING GLASS COLUMNS PACKED WITH 5% OV-17 ON CHROMOSORB WHP AND COLUMN TEMP INCREASED AT 4 DEGREES/MINUTE TO 250 DEGREES C. HYDROGEN, AIR AND NITROGEN CARRIER GASES AND A FLAME IONIZATION DETECTOR WERE UTILIZED. THIS METHOD GAVE 79.3% RECOVERY WITH A COEFFICIENT OF VARIATION FOR 0.3 MG/100 ML SAMPLES OF 6.9.|AFTER HYDROLYSIS OF THE GLUCURONIDE CONJUGATE OF DIMETHYLPHENYLCARBINOL (I), I IS EXTRACTED FROM THE URINE SAMPLE AT PH 8 WITH ETHYL ETHER. THE EXTRACT IS GAS-CHROMATOGRAPHED ON AN APIEZON L-COATED CHROMOSORB W COLUMN AT 130 DEGREES; I IS DETECTED BY FLAME IONIZATION. METHOD IS APPLICABLE TO THE EVALUATION OF THE DEGREE OF EXPOSURE TO ISOPROPYLBENZENE, OF WHICH I IS A METABOLITE.

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