Dextran sulfate sodium
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Dextran sulfate sodium
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CAS No:
9011-18-1
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Formula:
H2O4S.xNa.xUnspecified
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Chemical Name:
Dextran sulfate sodium
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Synonyms:
Dextran,hydrogen sulfate,sodium salt;Dextran sulfate sodium;Sodium dextran sulfate;Dextran sodium sulfate;Dextran sulfate sodium salt;Dextrarine;Dexulate;Dextran sulfuric acid ester sodium salt;Asuro;MDS;MDS (polysaccharide);Dexnon;MDS-Kowa A;Colyonal;Dextransulfate sodium sulfur;Dextralip 15;50935-35-8;57972-02-8;207464-10-6
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CAS No:
Description
Dextran sulfate sodium salt (MW 16000-24000) is a is a polymer of anhydroglucose with the molecular weight range of 16000-24000. Dextran sulfate sodium salt inhibits the replication of the human immunodeficiency virus by preventing the adsorption of the virus into host cells[1].
Characteristics
52.3
1.86
White to off-white; powder
92 °C
310 deg C
soluble in water
2-8°C
2.6X10-4 mm Hg at 25 deg C /Estimated/
Safety Information
NONH for all modes of transport
2
20/21/22-36/37/38
26-36-37/39-24/25
HH9290000
Xi,Xn
Stable in air.
P260, P261, P264, P270, P272, P273, P280, P302+P352, P307+P311, P314, P321, P333+P313, P363, P391, P405, P501
H317
Dextran sulfate sodium Use and Manufacturing
Dextran sulfate is a polyanionic derivative of dextran produced by esterification of Dextran with chlorosulphonic acid. The sulfur content is approximately 17% which corresponds to an average of 1.9 sulfate groups per glucosyl residue of the dextran molecule. Dextran sulfate sodium (DSS) is the sodium salt which is a white to off-white powder freely soluble in water and salt solutions to form a stable, clear solution. The high purity and reproducible quality enables its application in pharmaceuticals and biotechnology industry.
Dextran sulfate is used asa nucleic acid hybridization accelerant. The polyanionic character of Dextran sulfate helps to approximate nucleic acid strands, increasing their effective concentration to each other and promoting hybridization. Dextran sulfate also demonstrates a sequestering interaction with proteins, presumably through hydrogen-bonding between the sulfate groups and amine groups of the protein that generates an insoluble complex. The ability of the polymer to precipitate fibrinogen and low-density lipoproteins from plasma solutions has been used for analysis and for anticoagulant applications. Dextran Sulfate Sodium (DSS) which has proven to have versatile value in Biomedical/clinical research. DSS can be used to study Colitis (Inflammatory Bowel disease) as well as an antiviral as agent.Oral administration of dextran sulfate induces colonic inflammation in a mouse model of inflammatory bowel disease (IBD). Acute, chronic, and relapsing models of IBD can be induced by varying the concentration and administration frequency of dextran sulfate.
Dextran sulfate sodium shows immunologically relevant activities: enhancement and suppression of humoral immunity, polyclonal activation of B-lymphocytes, stimulating even immature B cells, changes in thymocyte reactivity to lectins, enhancement/suppression of cell-mediated immune responses. Precipitates LDL and VLDL lipoproteins - in the presence of magnesium ions, dextran sulfate precipitates low-density lipoproteins from human serum leaving the high-density lipoproteins in the supernatant. Removal of lipoproteins by dextran sulfate precipitation may be useful in the purification of other materials such as beta 2 glycoprotein.
Clinical reagent (HDL cholesterol determination). Clinical studies indicate a possible capacity of dextran sulfate to reduce edema. It is cited as a binder and skin conditioner.
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