Dextransulfatesodium 99%

Chemical property

Asuro light yellow powder; there is moisture. Soluble in water, alcohol, ether, insoluble. 6% water solution is colorless or light yellow transparent liquid, pH 5-7.5. Asuro began as a plasma substitute, for reducing blood fat. It can improve the activity of fibrinolytic system to prevent fibrin deposition and anticoagulant effect; can effectively improve lipoprotein lipase activity, promote free esterase to blood, chylomicrons decomposition and clarify the blood lipid; reduce the total cholesterol content in serum, lift the affinity of beta lipoprotein white and fibrous protein of vascular wall; antagonistic hyaluronidase, reduce the normal metabolism of vascular wall.

Dextran sulfate tablets enteric coated tablet of dextran sulfate, remove sugar, pale yellow piece of heart.

purpose

Blood lipid lowering drugs.

purpose

Lowering blood fat and anti atherosclerosis drugs.

Production method

Hydrolysis of the dextran water, heating, dissolving into 200g / L (20%), and hydrochloric acid to 0.3% - 0.4%, to hydrolyze 3h, slightly cold, with 100g / L (10%) NaOH solution and to pH6-6.5, to hydrolysate. Cooling, ethanol is added up to 40%, 30 DEG C for static for 24 hours supernatant vacuum concentrated to the original volume of 1 / 4, plus ethanol 70%, static 4-6, drying, and the precipitate was collected, micro molecular dextran. The viscosity of =0.03-0.04 (ETA), about 60% yield.

[HCl NaOH], [3h, dextran, pH6-6.5] hydrolysate [ethanol], micro molecular dextran

According to the esterification of micro molecular dextran (m) pyridine (V): chlorosulfonic acid (V) =1:6:1.48 ratio of feed. Take pyridine (or using formamide instead) into the reaction tank, stirring chlorination sulfonic acid at 25 DEG C, heating to 45 DEG C, into micro molecular dextran powder, thermal insulation 2.5-4h, static set hierarchical, dumping taking upper pyridine to obtain pasty ester.

Micro molecular dextran [pyridine, chlorosulfonic acid, [45-65 DEG C, 2.5-4h] paste ester (dextran esters pyridine sulfur trioxide salt)

Neutralization, drying the paste ester stirring cooling, by adding appropriate amount of water at 30 DEG C, 400g / L (40%) NaOH solution and to pH10-11, static layering, layer liquid adding proper amount of water and ethanol make the concentration reached 455 g / L (45.5%), in 37 degrees Celsius heat preservation stirring washing for 30 min, static, an aliquot of the lower liquid, repeat the washing twice. To dextran sulfate sodium solution. Then add appropriate amount of water, medicinal activated carbon, decolorization of 50 DEG C, filter pressing, the filtrate add appropriate amount of water and ethanol make ethanol was 47.5%, 37 DEG C for 30 min mixing, static, an aliquot of the lower liquid, lower solution with ethanol decantation dehydration, drying, drying at 50 DEG C, dextran sulfate sodium. The total yield of 54% dextran.

Paste ester [water, NaOH] > [30 DEG C, pH10-11] subnatant [ethanol] - > sugar anhydride ester sodium solution [water, activated carbon, filtrate [ethanol] - > [37 DEG C, 30min] sugar anhydride ester sodium

Enteric coated tablet made of dextran sulfate sodium tablets according to the requirements of the

Dextran sulfate sodium, dextran sulfate sodium tablets.