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Uracil

Uracil structure

CAS No:
66-22-8
Formula:
C4H4N2O2
Chemical Name:
Uracil
Synonyms:
2,4(1H,3H)-Pyrimidinedione;Uracil;2,4-Dioxopyrimidine;2,4-Pyrimidinediol;2,4-Dihydroxypyrimidine;Pyrod;Pirod;2,4-Pyrimidinedione;Hybar X;NSC 3970;4-Hydroxyuracil;1,2,3,4-Tetrahydropyrimidine-2,4-dione;766-19-8;4433-21-0;4433-24-3;42910-77-0;144104-68-7;138285-60-6;153445-42-2;51953-19-6
Categories:
Cosmetic Ingredient > Skin Conditioning

Description

Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA.

Solid

Uracil is a common and naturally occurring pyrimidine nucleobase in which the pyrimidine ring is substituted with two oxo groups at positions 2 and 4. Found in RNA, it base pairs with adenine and replaces thymine during DNA transcription. It has a role as a prodrug, a human metabolite, a Daphnia magna metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite, a mouse metabolite and an allergen. It is a pyrimidine nucleobase and a pyrimidone. It is a tautomer of a (4S)-4-hydroxy-3,4-dihydropyrimidin-2(1H)-one.|One of four nucleotide bases in the nucleic acid RNA.

Uracil Basic Attributes

Molecular Weight：

112.09

Exact Mass：

112.09

BRN：

606623

EC Number：

200-621-9

UNII：

56HH86ZVCT

NSC Number：

759649|29742|3970

DSSTox ID：

DTXSID4021424

HScode：

2933990090

Characteristics

PSA：

58.2

XLogP3：

-1.1

Appearance：

White to slightly yellow Crystalline Powder

Density：

1.5±0.1 g/cm3

Melting Point：

338 °C

Flash Point：

220.2±26.5 °C

Refractive Index：

1.640

Water Solubility：

SOLUBLE IN HOT WATER

Storage Conditions：

+15C to +30C

Vapor Pressure：

4.67e-05 mmHg

PKA：

9.45None

Collision Cross Section：

118.5 Å² [M+H]+ [CCS Type: DT, Method: single field calibrated with Agilent tune mix (Agilent)]|126.98 Å² [M+H]+ [CCS Type: DT, Method: stepped-field]|115 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine]|112.9 Å² [M-H]- [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|113.5 Å² [M-H]-

Safety Information

Hazard category：

4.2

Transport codes：

NONH for all modes of transport

wgk germany：

safety instructions：

22-24/25

RTECS Number：

YQ8650000

Marks：

Stability/Shelf Life：

Stable. Incompatible with strong oxidizing agents.

Precautionary statement(s)：

P201, P202, P261, P264, P271, P280, P281, P302+P352, P304+P340, P305+P351+P338, P308+P313, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H315

GHS Classification：

|Warning|H315 (50%): Causes skin irritation [Warning Skin corrosion/irritation]|P201, P202, P261, P264, P271, P280, P281, P302+P352, P304+P340, P305+P351+P338, P308+P313, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 16 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

Uracil

Uracil Use and Manufacturing

Uses

Used as pharmaceutical intermediates, but also for organic synthesis.Used in biochemical research. Used in the synthesis of medicines, as pharmaceutical intermediates, and also in organic synthesis

Production

< 25,000 lb

Manufacturing Info：

Printing and related support activities|2,4(1H,3H)-Pyrimidinedione: ACTIVE

Computed Properties

Molecular Weight:112.09
XLogP3:-1.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Exact Mass:112.027277375
Monoisotopic Mass:112.027277375
Topological Polar Surface Area:58.2
Heavy Atom Count:8
Complexity:161
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

It can block the degradation of tegafur and specifically increase the concentration of fluorouracil and its active metabolites in tumor tissues. When it is mixed with tegafur at a ratio of 1:4, it can significantly increase the concentration of fluorouracil in tumor tissues (maximum T/B ratio).

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Uracil Tegafur Tablets
Ingredients	This product is a compound preparation of tegafur and uracil. Each tablet contains 50 mg of tegafur and 0.112 g of uracil.
Indication	The tegafur contained in this product is alkaline and contains carbonate. Avoid using it with drugs containing calcium or magnesium ions or strong acidity.
Specifications	0.162g
Manufacturer	RenHe Hetero Pharmaceuticals Ltd.

Uracil Tegafur Tablets
Ingredients	This product is a compound preparation of tegafur and uracil. Each tablet contains 50 mg of tegafur and 0.112 g of uracil.
Indication	The tegafur contained in this product is alkaline and contains carbonate. Avoid using it with drugs containing calcium or magnesium ions or strong acidity.
Specifications	Tegafur 50mg, uracil 0.112g

Uracil
Manufacturer	Shandong Anxin Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

Shandong Anxin Pharmaceutical Co., Ltd.

China
Active
ASAHI KASEI FINECHEM CO LTD

United States
Inactive
KYOWA HAKKO KOGYO CO., LTD.

Brazil
Inactive

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Guide of Uracil

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
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Uracil

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