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Uracil arabinoside

Uracil arabinoside structure

CAS No:
3083-77-0
Formula:
C9H12N2O6
Chemical Name:
Uracil arabinoside
Synonyms:
2,4(1H,3H)-Pyrimidinedione,1-β-D-arabinofuranosyl-;Uracil,1-β-D-arabinofuranosyl-;1-β-D-Arabinofuranosyl-2,4(1H,3H)-pyrimidinedione;Spongouridine;Uracil arabinoside;1-β-D-Arabinofuranosyluracil;Arauridine;Uracil β-D-arabinofuranoside;Arabinosyluracil;Arabinofuranosyluracil;Spongouridin;Ara-U;NSC 68928;489-61-2;92418-86-5
Categories:
Biochemical Engineering > Saccharides

Description

1-beta-D-Arabinofuranosyluracil (Uracil 1-β-D-arabinofuranoside) isolated from the Caribbean sponge Tectitethya crypta, is a methoxyadenosine derivative. 1-beta-D-Arabinofuranosyluracil has demonstrated a diverse bioactivity profile including anti-inflammatory activity, analgesic and vasodilation properties[1]. 1-beta-D-Arabinofuranosyluracil reduces a proliferation of mouse lymphoma cells[2].

Spongouridin is a pyrimidine nucleoside.|A pyrimidine nucleoside formed in the body by the deamination of CYTARABINE.

Uracil arabinoside Basic Attributes

Molecular Weight：

244.2

Exact Mass：

244.20

EC Number：

221-386-9

NSC Number：

240592|68928|20256

DSSTox ID：

DTXSID80184832

HScode：

29349990

Characteristics

PSA：

119

XLogP3：

-2.85190

Appearance：

White to Off-white Powder

Density：

1.7±0.1 g/cm3

Melting Point：

213-216 °C

Refractive Index：

1.643

Storage Conditions：

2-8°C

Specific rotation：

(c = 2, H2O) [a]20 D = 9.4 ± 2°

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

36/37/38

safety instructions：

22-24/25-36-26

RTECS Number：

YQ8818000

Marks：

GHS Classification：

|Warning|H302 (50%): Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P260, P261, P264, P270, P271, P280, P281, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P308+P313, P312, P314, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 3 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

1 beta D Arabinofuranosyl Uracil

Uracil arabinoside Use and Manufacturing

Antiviral agent. Used for the treatment of severe acute respiratory syndrome (SARS).

Computed Properties

Molecular Weight:244.20
XLogP3:-2
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:244.06953611
Monoisotopic Mass:244.06953611
Topological Polar Surface Area:119
Heavy Atom Count:17
Complexity:371
Undefined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Tegafur in TS-1 inhibits thymidylate synthase, preventing deoxyuridylic acid from converting to deoxythymidylic acid, thereby interfering with DNA synthesis. Gimostat in TS-1 inhibits fluorouracil-degrading enzymes in the gastrointestinal tract, thereby prolonging the duration of drug action. Oxonamide potassium in TS-1 is a gastric mucosal protective agent.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

S-1 Capsules
Ingredients	Furouracil 5-chloro-2,4-dihydroxypyridine, oxazolidinone magnesium potassium (OXO plant growth inhibitor), tegafur.
Indication	(1) Contraindications for combined use of drugs (This product should not be used in combination with the following drugs) Drug name Clinical symptoms, treatment measures Mechanism, risk factors Fluorouracil antineoplastic drugs Fluorouracil (5-Fu, etc.) Tegafur-uracil combination preparations (UFT, etc.) Tegafur (Futraful) Doxifluridine (Furtulon) Capecitabine (Xeloda) Camofur (Mifurol) Combined use of drugs can lead to serious blood system disorders and digestive tract dysfunction such as diarrhea and stomatitis in the early stage. After discontinuing this product, it is necessary to wait at least 7 days before using other drugs. After discontinuing other drugs, it is also necessary to give this product again after an appropriate interval. The gimeracil in this product can inhibit the catabolism of 5-FU in the combined drug, causing a significant increase in the blood 5-FU concentration (refer to the pharmacokinetic item). Folinic acid Tegafur Uracil combined chemotherapy (folinic acid UFT, etc.) Calcium folinate Fluorouracil combined chemotherapy (calcium folinate 5-FU) Fluoropyrimidine antifungal drugs Flucytosine (2) Precautions for combined use (Caution should be taken when this product is used in combination with the following drugs) Drug name Clinical symptoms, treatment measures Mechanism, risk factors Phenytoin sodium Phenytoin sodium poisoning (nausea, vomiting, nystagmus, movement disorders, etc.) can occur. Closely observe the patient's condition. If abnormalities are found, stop using this product immediately and take appropriate measures. Tegafur can inhibit the metabolism of phenytoin sodium and increase its blood concentration. Dicoumarin potassium This product can enhance the effect of dicoumarin and lead to abnormal coagulation function. The mechanism is unknown Other anti-tumor drugs Radiation exposure, etc. can enhance the side effects of the blood system and digestive system. Pay attention to the patient's condition. If abnormalities are found, appropriate measures such as reducing the dose or stopping the drug should be taken. Side effects enhance each other.

S-1 Capsules

Ingredients

Furouracil 5-chloro-2,4-dihydroxypyridine, oxazolidinone magnesium potassium (OXO plant growth inhibitor), tegafur.

Indication

(1) Contraindications for combined use of drugs (This product should not be used in combination with the following drugs) Drug name Clinical symptoms, treatment measures Mechanism, risk factors Fluorouracil antineoplastic drugs Fluorouracil (5-Fu, etc.) Tegafur-uracil combination preparations (UFT, etc.) Tegafur (Futraful) Doxifluridine (Furtulon) Capecitabine (Xeloda) Camofur (Mifurol) Combined use of drugs can lead to serious blood system disorders and digestive tract dysfunction such as diarrhea and stomatitis in the early stage. After discontinuing this product, it is necessary to wait at least 7 days before using other drugs. After discontinuing other drugs, it is also necessary to give this product again after an appropriate interval. The gimeracil in this product can inhibit the catabolism of 5-FU in the combined drug, causing a significant increase in the blood 5-FU concentration (refer to the pharmacokinetic item). Folinic acid Tegafur Uracil combined chemotherapy (folinic acid UFT, etc.) Calcium folinate Fluorouracil combined chemotherapy (calcium folinate 5-FU) Fluoropyrimidine antifungal drugs Flucytosine (2) Precautions for combined use (Caution should be taken when this product is used in combination with the following drugs) Drug name Clinical symptoms, treatment measures Mechanism, risk factors Phenytoin sodium Phenytoin sodium poisoning (nausea, vomiting, nystagmus, movement disorders, etc.) can occur. Closely observe the patient's condition. If abnormalities are found, stop using this product immediately and take appropriate measures. Tegafur can inhibit the metabolism of phenytoin sodium and increase its blood concentration. Dicoumarin potassium This product can enhance the effect of dicoumarin and lead to abnormal coagulation function. The mechanism is unknown Other anti-tumor drugs Radiation exposure, etc. can enhance the side effects of the blood system and digestive system. Pay attention to the patient's condition. If abnormalities are found, appropriate measures such as reducing the dose or stopping the drug should be taken. Side effects enhance each other.

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Guide of Uracil arabinoside

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Drug Function and Efficacy
Related Drugs
Recommended Suppliers
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Uracil arabinoside

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