5-Chlorofuran-2-carboxylicacid
-
5-Chlorofuran-2-carboxylicacid
structure -
-
CAS No:
618-30-4
-
Formula:
C5H3ClO3
-
Chemical Name:
5-Chlorofuran-2-carboxylicacid
-
Synonyms:
5-Chloropyromucic acid;5-Chloro-2-furoic acid;5-CHLOROFURAN-2-CARBOXYLIC ACID;5-chloro-2-furoic acid(SALTDATA: FREE)
- Categories:
-
CAS No:
Safety Information
P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501
H315
|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 3 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
5-Chlorofuran-2-carboxylicacid Use and Manufacturing
Synthesis of N-(5-chlorofuran-2-ylcarbonyl)-3, 7- diazabicyclo [3.3.0] octane trifluoroacetate Example 7 relates to the synthesis of 5-chlorofuran-2- yl(hexahydropyrrolo[3, 4-c]pyrrol-2-yl)methanone trifluoroacetate (or N-(5- chlorofuran-2-ylcarbonyl)-3, 7-diazabicyclo[3.3.0]octane trofluoroacetate), which was prepared according to the following techniques, illustrative of the coupling reaction used to make heteroaromatic amides of 3, 7-diazabicyclo[3.3.0]octane: S-Chlorofuran-l-carboxylic acid; Aqueous sodium hydroxide (80 mL of 10percent) was added to a solution of silver nitrate (8.0 g, 47 mmol) in water (20 mL). This suspension was stirred and slowly treated with 30percent aqueous ammonium hydroxide until it became clear. A solution of S-chlorofuran^-carboxaldehyde (3.0 g, 23 mmol) (Aldrich Chemical) in methanol (5 mL) was added, and the resulting mixture was stirred at ambient temperature for 30 min. The reaction mixture was filtered, and the filtrate was washed with ether (100 mL). The aqueous filtrate was then made acidic (~pH 3) by the addition of cold 20percent sulfuric acid. The resulting mixture was extracted with ethyl acetate (3 x 100 mL). The extracts were washed with saturated aqueous sodium chloride solution (100 mL), dried (anhydrous sodium sulfate) and concentrated under vacuum to give 3.2 g (95percent yield) of white solid (mp 178- 179To a mixture of compound 1 b2 (3.0 g, 1.0 eq.) and CH2CI2 (30 mL) at O0C is added DMF (0.1 mL) and (COCI)2 (6.7 g, 2.5 eq.). The mixture is allowed to stir at room temperature for 3 h, then concentrated under reduced pressure to give compound 1b3.
Computed Properties
Molecular Weight:146.53
XLogP3:1.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:145.9770716
Monoisotopic Mass:145.9770716
Topological Polar Surface Area:50.4
Heavy Atom Count:9
Complexity:125
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Recommended Suppliers of 5-Chlorofuran-2-carboxylicacid
-
![China]()
CN
5 YRS
Business licensedTrader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives -
![China]()
CN
5 YRS
Business licensedTrader Supplier of PVC resin,pvc paste resin,melamine
Learn More Other Chemicals
-
4-Mercaptophenylboronic acid
237429-33-3
-
(4-BENZYLOXYCARBONYLPHENYL)BORONIC ACID
184000-11-1
-
(4-chlorophenyl)methoxy-trimethylsilane
14856-74-7
-
4,4'-DIBROMO-TRANS-STILBENE Formula
18869-30-2
-
(R)-(-)-1-[(S)-2-(DI(3,5-DIMETHYL-4-METHOXYPHENYL)PHOSPHINO)FERROCENYL]ETHYLDICYCLOHEXYLPHOSPHINE Formula
360048-63-1
-
4-BENZYLOXY-3-CHLOROPHENYLBORONIC ACID Formula
845551-44-2
-
4,5-dichloro-4,5-difluoro-2,2-bis(trifluoromethyl)-1,3-dioxolane Structure
60644-92-0
-
2-Methyl-2H-indazole-4-boronic acid pinacol ester Structure
885698-95-3
-
What is 3-HEPTAFLUOROPROPYL-5-METHYL-4-NITROPYRAZOLE
82633-69-0
-
What is 2,6-Dinitro-4-(trifluoromethyl)phenol
393-77-1