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(-)-Gossypol

(-)-Gossypol structure

CAS No:
90141-22-3
Formula:
C30H30O8
Chemical Name:
(-)-Gossypol
Synonyms:
[2,2′-Binaphthalene]-8,8′-dicarboxaldehyde,1,1′,6,6′,7,7′-hexahydroxy-3,3′-dimethyl-5,5′-bis(1-methylethyl)-,(2R)-;[2,2′-Binaphthalene]-8,8′-dicarboxaldehyde,1,1′,6,6′,7,7′-hexahydroxy-3,3′-dimethyl-5,5′-bis(1-methylethyl)-,(R)-;(2R)-1,1′,6,6′,7,7′-Hexahydroxy-3,3′-dimethyl-5,5′-bis(1-methylethyl)[2,2′-binaphthalene]-8,8′-dicarboxaldehyde;(-)-Gossypol;(R)-Gossypol;(R)-(-)-Gossypol;AT 101;SML 0433
Categories:
Organic Chemistry > Dioxins and Dioxin-like Compounds

Description

(R)-(-)-Gossypol (AT-101) is the levorotatory isomer of a natural product Gossypol. AT-101 is determined to bind to Bcl-2, Mcl-1 and Bcl-xL proteins with Kis of 260±30 nM, 170±10 nM, and 480±40 nM, respectively.

(-)-Gossypol Basic Attributes

Molecular Weight：

518.562

Exact Mass：

518.55

Characteristics

PSA：

156

XLogP3：

8.22 (est)

Density：

1.4±0.1 g/cm3

Melting Point：

166-167 °C

Boiling Point：

707.9±55.0 °C at 760 mmHg

Flash Point：

395.9±28.0 °C

Refractive Index：

1.742

Water Solubility：

In water, 1.76X10-4 mg/L at 25 deg C (est)

Storage Conditions：

Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2 - 8 deg C

Vapor Pressure：

7.06X10-21 mm Hg at 25 deg C (est)

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

Precautionary statement(s)：

P201, P202, P281, P308+P313, P405, P501

Hazard Statements：

H351

(-)-Gossypol Use and Manufacturing

AT-101 is a BH3 mimetic known to be a potent inhibitor of antiapoptotic Bcl-2 family members.

Recommended Suppliers of (-)-Gossypol

Guangzhou Yaoguang Technology Co., Ltd. Contact Supplier

CN
5 YRS

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90141-22-3

CAS No.: 90141-22-3

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