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EGTA

EGTA structure

CAS No:
67-42-5
Formula:
C14H24N2O10
Chemical Name:
EGTA
Synonyms:
6,9-Dioxa-3,12-diazatetradecanedioic acid,3,12-bis(carboxymethyl)-;Acetic acid,[ethylenebis(oxyethylenenitrilo)]tetra-;3,12-Bis(carboxymethyl)-6,9-dioxa-3,12-diazatetradecanedioic acid;EBONTA;EGTA;[Ethylenebis(oxyethylenenitrilo)]tetraacetic acid;Ethylene glycol bis(β-aminoethyl ether)-N,N,N′,N′-tetraacetic acid;GEDTA;Ethylene glycol bis(2-aminoethyl ether)-N,N,N′,N′-tetraacetic acid;2,2′-Ethylenedioxybis(ethylamine)-N,N,N′,N′-tetraacetic acid;3,6-Dioxaoctane-1,8-diamine-N,N,N′,N′-tetraacetic acid;Egtazic acid;1,2-Bis(2-aminoethoxyethane)-N,N,N′,N′-tetraacetic acid;EDGA;NSC 615010;Chelest GEA;O,O′-Bis(2-aminoethyl)ethylene glycol-N,N,N′,N′-tetraacetic acid;Glycoletherdiamine-N,N,N′,N′-tetraacetic acid;3,12-bis(carboxymethyl)-6,9-dioxa-3,12-diazatetradecane-1,14-dioic acid;3,6-Dioxaoctane-1,8-diamine-N,N,N′,N′-tetracetic acid;Ethylene glycol tetraacetic acid;2-[2-[2-[2-[Bis(carboxymethyl)amino]ethoxy]ethoxy]ethyl-(carboxymethyl)amino]acetic acid;33382-61-5;56618-01-0
Categories:
Analytical Chemistry > Standard

Description

White to slightly off-white powder

Ethylene glycol bis(2-aminoethyl)tetraacetic acid is a diether that is ethylene glycol in which the hydrogens of the hydroxy groups have been replaced by 2-[bis(carboxymethyl)amino]ethyl group respectively. It has a role as a chelator. It is a tetracarboxylic acid, a tertiary amino compound and a diether.|A chelating agent relatively more specific for calcium and less toxic than EDETIC ACID.

EGTA Basic Attributes

Molecular Weight：

380.34800

Exact Mass：

380.35

EC Number：

200-651-2

UNII：

526U7A2651

NSC Number：

615010

DSSTox ID：

DTXSID2045151

HScode：

29225000

Characteristics

PSA：

174.14000

XLogP3：

-6.2

Appearance：

White powder.

Density：

1.433 g/cm3

Melting Point：

240-245ºC

Boiling Point：

678ºC at 760 mmHg

Flash Point：

363.9ºC

Refractive Index：

1.547

Water Solubility：

H2O: slightly soluble

Storage Conditions：

Store at RT.

Toxicity：

LD50 orally in Rabbit: 3587 mg/kg

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

R36/37/38

safety instructions：

S24/25

RTECS Number：

AH3760000

Marks：

Stability/Shelf Life：

Stable under normal temperatures and pressures.

Precautionary statement(s)：

P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H315

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 10 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Agents counteracting or neutralizing the action of POISONS. (See all compounds classified as Antidotes.)|Substances that bind to and sequester CALCIUM ions. (See all compounds classified as Calcium Chelating Agents.)

MeSH Entry Terms：

Acid, Egtazic

EGTA Use and Manufacturing

Uses

EGTA (ethylene glycol-bis(β-aminoethyl ether)-N,N,N',N'-tetraacetic acid) is an aminopolycarboxylic acid, a chelating agent. It is a colourless solid that is related to the better known EDTA. Compared to EDTA, it has a lower affinity for magnesium, making it more selective for calcium ions. It is useful in buffer solutions that resemble the environment in living cells where calcium ions are usually at least a thousandfold less concentrated than magnesium.The pKa for binding of calcium ions by tetrabasic EGTA is 11.00, but the protonated forms do not significantly contribute to binding, so at pH 7, the apparent pKa becomes 6.91. See Qin et al. for an example of a pKa calculation.EGTA has also been used experimentally for the treatment of animals with cerium poisoning and for the separation of thorium from the mineral monazite. EGTA is used as a compound in elution buffer in the protein purification technique known as tandem affinity purification, in which recombinant fusion proteins are bound to calmodulin beads and eluted out by adding EGTA.EGTA is often employed in dentistry and endodontics for the removal of the smear layer.

Manufacturing Info：

6,9-Dioxa-3,12-diazatetradecanedioic acid, 3,12-bis(carboxymethyl)-: ACTIVE

Computed Properties

Molecular Weight:380.35
XLogP3:-6.2
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:12
Rotatable Bond Count:17
Exact Mass:380.14309497
Monoisotopic Mass:380.14309497
Topological Polar Surface Area:174
Heavy Atom Count:26
Complexity:397
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Chloroacetic acid

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