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3-Ethoxybenzenamine

3-Ethoxybenzenamine structure

CAS No:
621-33-0
Formula:
C8H11NO
Chemical Name:
3-Ethoxybenzenamine
Synonyms:
Benzenamine,3-ethoxy-;m-Phenetidine;3-Ethoxybenzenamine;3-Ethoxyaniline;m-Ethoxyaniline;m-Ethoxyphenylamine;(3-Ethoxyphenyl)amine;NSC 9817;3-Aminophenyl ethyl ether
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

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Description

light yellow to dark red liquid

M-phenetidine is a dark red liquid. (NTP, 1992)

3-Ethoxybenzenamine Basic Attributes

Molecular Weight：

137.18

Exact Mass：

137.18

EC Number：

210-680-2

UNII：

XE9KKL972R

NSC Number：

9817

UN Number：

2311

DSSTox ID：

DTXSID0025862

HScode：

29222200

Characteristics

PSA：

35.2

XLogP3：

1.37

Appearance：

Clear brown Liquid

Density：

1.0666 g/cm³ @ Temp: 20 °C

Melting Point：

204 °C

Boiling Point：

248 °C

Flash Point：

>230 °F

Refractive Index：

1.545

Water Solubility：

H2O: 0.1-0.5 g/100 mL at 20 ºC

Storage Conditions：

Store below +30°C.

Vapor Pressure：

1 mm Hg at 153° F ; 5 mm Hg at 202.5° F; 760 mm Hg at 442° F (NTP, 1992)

Toxicity：

mma-sat 1 mg/plate EMMUEG 11(Suppl12),1,88

Flammability characteristics：

Open flame is flammable; emit toxic aniline gas when heated

Air and Water Reactions：

Slightly soluble in water.

Reactive Group：

Amines, Aromatic

Reactivity Profile：

M-PHENETIDINE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Safety Information

Packing level：

III

Hazard category：

6.1(b)

Transport codes：

UN 2311 6.1/PG 3

wgk germany：

hazard class code：

23/24/25-33

safety instructions：

28-36/37/39-45-36/37-28A

RTECS Number：

SI5400000

Marks：

Storage features：

The warehouse is ventilated, low temperature and dry; stored and transported separately from food materials

Stability/Shelf Life：

Stable. Combustible. Incompatible with strong oxidizing agents, acids, acid chlorides, acid anhydrides. Sensitive to prolonged exposure to light and air.

Precautionary statement(s)：

P261-P280-P301 + P310-P311

Hazard Statements：

H301 + H311 + H331-H373

Fire Hazards：

This chemical is probably combustible. (NTP, 1992)

GHS Classification：

|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P260, P261, P264, P270, P271, P280, P301+P310, P302+P352, P304+P340, P311, P312, P314, P321, P322, P330, P361, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 71 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Fire Fighting：

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)

Isolation and Evacuation：

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]: As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

Nonfire Spill Response：

SMALL SPILLS AND LEAKAGE: If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then, use absorbent paper to pick up all liquid spill material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should protect this chemical from exposure to light. Keep the container tightly closed under an inert atmosphere, and store under refrigerated temperatures. STORE AWAY FROM SOURCES OF IGNITION. (NTP, 1992)

Personal Protective Equipment：

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

Toxicity

Toxicity class：

moderately toxic

Drug Information

Health Hazards：

SYMPTOMS: Symptoms of exposure to this compound may include cyanosis, hypothermia, headache, drowsiness, vomiting, nephritis and irritation of the alimentary tract. ACUTE/CHRONIC HAZARDS: When heated to decomposition this compound emits toxic fumes. (NTP, 1992)

First Aid：

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

3-Ethoxybenzenamine Use and Manufacturing

Methods of Manufacturing

It is derived from m-aminophenol through acetylation, alkylation, hydrolysis and neutralization. 1. Acetylation: Add m-aminophenol to acetic acid and heat to reflux for 8 hours. After the acetic acid is recovered, it is separated by water and filtered after cooling to obtain acetaminophen ([621-42-1]). 2. Alkylation Add ethanol, sodium hydroxide, m-acetaminophen, and bromoethane into the reactor, heat to reflux for 8 hours, pour into water and cool and filter to obtain m-acetaminophen ethyl ether. 3. Hydrolysis and neutralization Mix m-acetaminophen ethyl ether with industrial hydrochloric acid, heat it in a water bath for 8 hours, then pour it into water, and neutralize it with 40% sodium hydroxide to alkaline. Separate the oil layer. The aqueous solution is extracted with ether, and the ether is recovered and distilled under reduced pressure with the oil layer. The 140-144°C (2.0kPa) fraction is collected under the protection of nitrogen, which is m-ethoxyaniline.

Uses

Used in organic synthesis.

Manufacturing Info：

Benzenamine, 3-ethoxy-: INACTIVE

Computed Properties

Molecular Weight:137.18
XLogP3:1.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:137.084063974
Monoisotopic Mass:137.084063974
Topological Polar Surface Area:35.2
Heavy Atom Count:10
Complexity:95.3
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of 3-Ethoxybenzenamine

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3-Ethoxyaniline cas 621-33-0 COA certification high quality from China

CAS No.: 621-33-0

Grade: Industrial Grade

Content: 99.5%

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3-Ethoxyaniline 621-33-0

CAS No.: 621-33-0

Grade: Industrial Grade

Content: 99%

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