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Friedelin

Friedelin structure

CAS No:
559-74-0
Formula:
C30H50O
Chemical Name:
Friedelin
Synonyms:
24,25,26-Trinoroleanan-3-one,5,9,13-trimethyl-,(4β,5β,8α,9β,10α,13α,14β)-;D:A-Friedooleanan-3-one;Friedelin;(4β,5β,8α,9β,10α,13α,14β)-5,9,13-Trimethyl-24,25,26-trinoroleanan-3-one;(-)-Friedelin;Friedelan-3-one;Friedeline;Friedelanone;3(2H)-Picenone,eicosahydro-4,4a,6b,8a,11,11,12b,14a-octamethyl-,[4R-(4α,4aα,6aβ,6bα,8aα,12aα,12bβ,14aα,14bβ)]-;3(2H)-Picenone,eicosahydro-4,4a,6b,8a,11,11,12b,14a-octamethyl-,(4R,4aS,6aS,6bR,8aR,12aR,12bS,14aS,14bS)-;NSC 55141;3-Oxofriedelane
Categories:
Natural Products > Terpenes

Description

Friedelin is isolated from isolated from the leaves of Maytenus ilicifolia(Mart). Friedelin is a noncompetitive inhibitor of CYP3A4 with IC50 and Kivalues of 10.79 μM and 6.16 μM, respectively. Friedelin is also a competitive inhibitor of CYP2E1 with IC50 and Ki values of 22.54 μM and 18.02 μM, respectively[1].

Friedelin is a pentacyclic triterpenoid that is perhydropicene which is substituted by an oxo group at position 3 and by methyl groups at the 4, 4a, 6b, 8a, 11, 11, 12b, and 14a-positions (the 4R,4aS,6aS,6bR,8aR,12aR,12bS,14aS,14bS-enantiomer). It is the major triterpenoid constituent of cork. It has a role as an anti-inflammatory drug, a non-narcotic analgesic, an antipyretic and a plant metabolite. It is a pentacyclic triterpenoid and a cyclic terpene ketone.

Friedelin Basic Attributes

Molecular Weight：

426.72

Exact Mass：

426.72

EC Number：

209-205-1

UNII：

AK21264UAD

Characteristics

PSA：

17.1

XLogP3：

10.87

Density：

1.0±0.1 g/cm3

Melting Point：

263 °C

Boiling Point：

477.2±13.0 °C at 760 mmHg

Flash Point：

233.9±12.1 °C

Refractive Index：

1.503

Storage Conditions：

2-8°C

Specific rotation：

D -27.8° (chloroform)

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

Drug Information

MeSH Entry Terms：

friedelanone

Computed Properties

Molecular Weight:426.7
XLogP3:9.8
Hydrogen Bond Acceptor Count:1
Exact Mass:426.386166214
Monoisotopic Mass:426.386166214
Topological Polar Surface Area:17.1
Heavy Atom Count:31
Complexity:781
Defined Atom Stereocenter Count:9
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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FRIEDELIN 98.5% high purity

CAS No.: 559-74-0

Grade: Pharmaceutical Grade

Content: 98.5%

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Friedelin

CAS No.: 559-74-0

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Guide of Friedelin

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Computed Properties
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Friedelin

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