3-Methyl-2-butanone

86.1323

86.13

209-264-3

V8DP6THY5O

0922

9379

2397

DTXSID0022062

Colorless liquid

29141990

17.1

0.84

3-methylbutan-2-one appears as a colorless liquid with a pleasant odor. Flash point below 70°F. Less dense than water. May be toxic by inhalation and skin absorption. Used as a solvent.

0.80 g/cm³

-92 °C

93 °C

43°F

1.387-1.389

6 g/L (20 ºC)

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Store in cool place.

Vapour pressure, kPa at 20°C: 5.5

Relative vapour density (air = 1): 3.0

LD50 orally in male mice: 29.86 mmol/kg (Tanii)

Combustible Liquid

vol% in air: 1.2

The odor threshold lies between 1.9 and 3.1 ppm (6.8 and 11 mg/cu m). Acetone-like odor.

2.87e-12 cm3/molecule*sec

Henry's Law constant = 1.13X10-4 atm-cu m/mol at 25 °C (est)

Flammable|Specific gravity: 0.815 at 15 °C/4 °C|When heated to decomposition it emits acrid smoke and irritating fumes.|Hydroxyl radical reaction rate constant = 2.87X10-12 cu-cm/molecule-sec at 25 °C

Highly flammable. Soluble in water.

Ketones

Highly Flammable

Ketones, such as 3-METHYLBUTAN-2-ONE, are reactive with many acids and bases liberating heat and flammable gases (e.g., H2). The amount of heat may be sufficient to start a fire in the unreacted portion of the ketone. Ketones react with reducing agents such as hydrides, alkali metals, and nitrides to produce flammable gas (H2) and heat. Ketones are incompatible with isocyanates, aldehydes, cyanides, peroxides, and anhydrides. They react violently with aldehydes, HNO3, HNO3 + H2O2, and HClO4.

1.8 °F|475 °C

9.32 eV

Lower limit 9.0 °F; Upper limit 0.85 °F|Combustible Liquid

The vapour is heavier than air and may travel along the ground; distant ignition possible. The vapour mixes well with air, explosive mixtures are easily formed.

II

3

2397

1

R11

9-16-33

EL9100000

F

Fireproof. Separated from flammable substances and strong oxidants. Well closed. Store in an area without drain or sewer access.

Stable under normal temperatures and pressures.

P210, P233, P240, P241, P242, P243, P280, P303+P361+P353, P370+P378, P403+P235, P501

H225

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.|SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.|Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable. Observe all federal, state, and local environmental regulations. Contact a licensed professional waste disposal service to dispose of this material.

Vapors may form explosive mixture with air.|Can react vigorously with oxidizing materials.

Special Hazards of Combustion Products: Acrid smoke and fumes (USCG, 1999)|Highly flammable. Heating will cause rise in pressure with risk of bursting. Vapour/air mixtures are explosive.|Flammable - 3rd degree

|Danger|H225: Highly Flammable liquid and vapor [Danger Flammable liquids]|P210, P233, P240, P241, P242, P243, P280, P303+P361+P353, P370+P378, P403+P235, and P501|H225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]|P210, P233, P240, P241, P242, P243, P261, P271, P280, P303+P361+P353, P304+P312, P304+P340, P312, P370+P378, P403+P233, P403+P235, P405, and P501|Aggregated GHS information provided by 355 companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|P201, P202, P210, P233, P240, P241, P242, P243, P261, P264, P271, P280, P281, P302+P352, P303+P361+P353, P304+P312, P304+P340, P305+P351+P338, P308+P313, P312, P321, P332+P313, P337+P313, P362, P370+P378, P403+P233, P403+P235, P405, and P501|P210, P233, P240, P241, P242, P243, P261, P264, P271, P280, P301+P310, P302+P352, P303+P361+P353, P304+P312, P304+P340, P305+P351+P338, P312, P321, P331, P332+P313, P337+P313, P362, P370+P378, P403+P233, P403+P235, P405, and P501

Excerpt from ERG Guide 127 [Flammable Liquids (Water-Miscible)]: As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. LARGE SPILL: Consider initial downwind evacuation for at least 300 meters (1000 feet). FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

Excerpt from ERG Guide 127 [Flammable Liquids (Water-Miscible)]: ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor-suppressing foam may be used to reduce vapors. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. Use clean, non-sparking tools to collect absorbed material. LARGE SPILL: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor, but may not prevent ignition in closed spaces. (ERG, 2016)

Skin: Wear appropriate personal protective clothing to prevent skin contact. Eyes: Wear appropriate eye protection to prevent eye contact. Wash skin: The worker should immediately wash the skin when it becomes contaminated. Remove: Work clothing that becomes wet or significantly contaminated should be removed and replaced. Change: No recommendation is made specifying the need for the worker to change clothing after the work shift. (NIOSH, 2016)|Wear appropriate personal protective clothing to prevent skin contact.|Wear appropriate eye protection to prevent eye contact.|Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).|(See protection codes)

Flammable when exposed to heat or flame

Explosive limits , vol% in air: 1.2-8

Water may be ineffective.|For small (incipient) fires, use media such as "alcohol" foam, dry chemical, or carbon dioxide. For large fires, apply water from as far as possible. Use very large quantities (flooding) of water applied as a mist or spray; solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Wear self contained breathing apparatus for fire fighting if necessary. Use water spray to cool unopened containers.

Personal precautions: Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Methods and materials for containment and cleaning up: Contain spillage, and then collect with non-combustible absorbent material, (e.g. sand, earth, diatomaceous earth, vermiculite) and place in container for disposal according to local/national regulations.

The worker should immediately wash the skin when it becomes contaminated.|Work clothing that becomes wet or significantly contaminated should be removed and replaced.|Avoid inhalation of vapor or mist. Keep away from sources of ignition - No smoking. Take measures to prevent the build up of electrostatic charge.|Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.|For more Preventive Measures (Complete) data for Methyl isopropyl ketone (6 total), please visit the HSDB record page.

/GUIDE 127: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE)/ Fire or Explosion: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a "P" may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.|/GUIDE 127: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE)/ Health: Inhalation or contact with material may irritate or burn skin and eyes. Fire may produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control may cause pollution.|/GUIDE 127: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE)/ Public Safety: CALL Emergency Response Telephone Number ... As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate closed spaces before entering.|/GUIDE 127: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Structural firefighters' protective clothing will only provide limited protection.|For more DOT Emergency Guidelines (Complete) data for Methyl isopropyl ketone (8 total), please visit the HSDB record page.

A skin and eye irritant.

Recommended Exposure Limit: 10 Hr Time-Weighted Avg: 200 ppm (705 mg/cu m).

Consult an expert! Personal protection: self-contained breathing apparatus. Remove all ignition sources. Collect leaking liquid in covered containers. Absorb remaining liquid in dry sand or inert absorbent. Then store and dispose of according to local regulations. Do NOT wash away into sewer.

Fireproof. Separated from flammable substances and strong oxidants. Well closed. Store in an area without drain or sewer access.

A harmful contamination of the air will be reached quickly on evaporation of this substance at 20 °C.

The substance is irritating to the eyes, skin and respiratory tract. If swallowed the substance may cause vomiting and could result in aspiration pneumonitis. The substance may cause effects on the central nervous system. This may result in lowering of consciousness.

May cause skin dryness or cracking

NO open flames, NO sparks and NO smoking. Closed system, ventilation, explosion-proof electrical equipment and lighting.

Use ventilation, local exhaust or breathing protection.

Protective gloves.

Wear safety goggles or eye protection in combination with breathing protection.

| 4 - Materials that, under emergency conditions, can be lethal.| 3 - Liquids and solids that can be ignited under almost all ambient temperature conditions. Materials produce hazardous atmospheres with air under almost all ambient temperatures or, though unaffected by ambient temperatures, are readily ignited under almost all conditions.| 1 - Materials that in themselves are normally stable but that can become unstable at elevated temperatures and pressures.| 1 - Materials that, under emergency conditions, can cause significant irritation.| 4 - Materials that rapidly or completely vaporize at atmospheric pressure and normal ambient temperature or that are readily dispersed in air and burn readily.| 0 - Materials that in themselves are normally stable, even under fire conditions.

Methyl isopropyl ketone was listed among approximately 200 gas-phase organic species that have been reported in the literature as emanating from either gasoline or diesel vehicles but were not identified in vehicle emissions collected from the Allegheny Mountain tunnel of the Pennsylvania Turnpike during 1979(1). Methyl isopropyl ketone was detected in headspace sampling of waste building materials consisting of mold-infested fiberboard or wall paper(2,3). It was also detected in the headspace air and liquid exudate of garden waste(2,3).|During a study of organic components in aqueous effluents from energy-related processes, methyl isopropyl ketone was detected at 55 ppb in a product water sample from an in situ coal gasification facility in Hanna, WY, at 89 ppb in process water from an in situ coal gasification facility in Gillette, WY, and at 20 ppb in retort water from an in situ oil shale processing facility in Rock Springs, WY(1). Methyl isopropyl ketone was detected in treated water samples collected following ozonation(2).|During a study exploring potential carbonyl compound by-products of ozone wastewater treatment, methyl isopropyl ketone was detected in samples of final liquor from a sludge-pressing plant following ozonization of the sample in a laboratory(1). Methyl isopropyl ketone was identified as one of the products of the reaction of hydroxyl radicals with 2,3,4-trimethylpentane in the presence of NO. The reported experimental molar yield was approximately 41%(2).

URBAN/SUBURBAN: Methyl isopropyl ketone was identified in air samples collected from Grenoble, France(1).|RURAL/REMOTE: Methyl isopropyl ketone was identified in air samples collected in the Southern Black Forest of Germany(1).|SOURCE DOMINATED: Methyl isopropyl ketone was detected in ambient air samples collected from South Charleston, West Virginia in the Kanawha Valley. The concentration was not reported. It was also tentatively identified in ambient air samples from St. Albans, West Virginia within the same region. Methyl isopropyl ketone was tentatively identified in ambient air samples collected from West Belle, Virginia in the Shenandoah Valley(1).

LD50 Rabbits sc 5080 mg/kg bw|LD50 Rats oral 4528 mg/kg bw|LD50 Mice (male) oral 29-86 mmol/kg|LD50 Rat (Crl:CD (SD)BR, M/F) oral 3,078 mg/kg (both sexes)|For more Non-Human Toxicity Values (Complete) data for Methyl isopropyl ketone (10 total), please visit the HSDB record page.

Methyl isopropyl ketone's production and use as a solvent for nitrocellulose lacquers(1) and as an intermediate for the production of pharmaceuticals, herbicides, dye precursors, its use in the synthesis of rubber auxiliaries, and for the selective extraction of rare earth elements(2) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 38(SRC), determined from a log Kow of 0.84(2) and a regression-derived equation(3), indicates that methyl isopropyl ketone is expected to have very high mobility in soil(SRC). Volatilization of methyl isopropyl ketone from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 1.13X10-4 atm-cu m/mole(SRC), derived from its vapor pressure, 52.2 mm Hg at 25 °C(4), and water solubility, 5.237X10+4 mg/L(5). Methyl isopropyl ketone is expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(4). Methyl isopropyl ketone reached 99% of its theoretical BOD using an activated sludge inoculum in the Japanese MITI test(6) suggesting that biodegradation is an important environmental fate process for this substance in soil(SRC).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 38(SRC), determined from a log Kow of 0.84(2) a regression-derived equation(3), indicates that methyl isopropyl ketone is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(4) based upon an estimated Henry's Law constant of 1.13X10-4 atm-cu m/mole(SRC), derived from its vapor pressure, 52.2 mm Hg at 25 °C(5), and water solubility, 5.237X10+4 mg/L at 30 °C(6). Using this Henry's Law constant and an estimation method(4), volatilization half-lives for a model river and model lake are 5.8 hours and 5.9 days, respectively(SRC). According to a classification scheme(7), an estimated BCF of 1.4(SRC), from its log Kow(2) and a regression-derived equation(8), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Methyl isopropyl ketone reached 99% of its theoretical BOD using an activated sludge inoculum in the Japanese MITI test(9) suggesting that biodegradation is an important environmental fate process for this substance in water(SRC).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), methyl isopropyl ketone, which has a vapor pressure of 52.2 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase methyl isopropyl ketone is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 5.6 days(SRC), calculated from its rate constant of 2.87X10-12 cu cm/molecule-sec at 25 °C(3). Methyl isopropyl ketone's UV absorption spectrum shows maximum absorption near 280 nm with a shoulder extending above 290 nm(4); therefore, this substance may be susceptible to direct photolysis by sunlight(SRC).

The rate constant for the vapor-phase reaction of methyl isopropyl ketone with photochemically-produced hydroxyl radicals has been measured as 2.87X10-12 cu cm/molecule-sec at 25 °C(1). This corresponds to an atmospheric half-life of about 5.6 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(2). Methyl isopropyl ketone is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(3). Methyl isopropyl ketone's UV absorption spectrum shows maximum absorption near 280 nm with a shoulder extending above 290 nm(4); therefore, this substance may be susceptible to direct photolysis by sunlight(SRC).

An estimated BCF of 1.4 was calculated in fish for methyl isopropyl ketone(SRC), using a log Kow of 0.84(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC), provided the compound is not metabolized by the organism(SRC).

The Koc of methyl isopropyl ketone is estimated as 38(SRC), using a log Kow of 0.84(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that methyl isopropyl ketone is expected to have very high mobility in soil.

The Henry's Law constant for methyl isopropyl ketone is estimated as 1.13X10-4 atm-cu m/mole(SRC) derived from its vapor pressure, 52.2 mm Hg(1), and water solubility, 5.24X10+4 mg/L(2). This Henry's Law constant indicates that methyl isopropyl ketone is expected to volatilize from water surfaces(3). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(3) is estimated as 5.8 hours(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(3) is estimated as 5.9 days(SRC). Methyl isopropyl ketone's (estimated) Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). The potential for volatilization of methyl isopropyl ketone from dry soil surfaces may exist(SRC) based upon a vapor pressure of 52.2 mm Hg(1).

DRINKING WATER: Methyl isopropyl ketone was detected in finished drinking water collected from the following U.S. cities: Cincinnati, Ohio; Miami, Florida; Ottumwa, Iowa; Philadelphia, Pennsylvania; and Seattle, Washington(1,2). All samples were from surface-water supplied except for the drinking water sampled in Miami, which was groundwater supplied(1).|RAIN/SNOW/FOG: A measured logarithmic snow surface/air sorption coefficient of -3.38 cu m/sq m has been reported for methyl isopropyl ketone(1).

Methyl isopropyl ketone has been detected in the meat volatiles of chicken and beef(1). Reported mean concentrations of methyl isopropyl ketone measured in the headspace volatiles of wines from six regions of the Napa Valley, California ranged from 0.001 to 0.225 mg/L(2).

ENVIRONMENTAL: During a study of the occurrence of volatile organic compounds in human milk samples from five industrial US cities, methyl isopropyl ketone was detected in one milk sample collected in Jersey City, NJ and one milk sample collected in Pittsburgh, PA(1,2).

According to the 2006 TSCA Inventory Update Reporting data, the number of persons reasonably likely to be exposed in the industrial manufacturing, processing, and use of methyl isopropyl ketone is 1 to 99; the data may be greatly underestimated(1).|Occupational exposure to methyl isopropyl ketone may occur through inhalation and dermal contact with this compound at workplaces where methyl isopropyl ketone is produced or used. Monitoring data indicate that the general population may be exposed to methyl isopropyl ketone via inhalation of ambient air, ingestion of food and drinking water, and dermal contact with this compound. (SRC)

Methyl isopropyl ketone was detected in exhaled breath samples collected from a prediabetic population of 14 Chicago, Illinois residents(1). During a study of the occurrence of volatile organic compounds in human milk samples from five industrial US cities, methyl isopropyl ketone was detected in one milk sample collected in Jersey City, NJ and one milk sample collected in Pittsburgh, PA(2,3).

When a dose of 1000 mg/kg methyl isopropyl ketone was administered to rats, 38-54% was eliminated unchanged in 25-35 hours, predominantly in the expired air.

Ketones are not readily metabolized in the body. With most of the lower ketones as much as 50% of the dose may be eliminated unchanged from the body, mainly in the exhaled air and to a small extent in the urine. The major metabolic pathway of ketones is reduction to the corresponding secondary alcohols, which are usually eliminated as glucuronic acids. In rats, 38-54% of a dose of 1000 mg/kg bw methyl isopropyl ketone was eliminated unchanged in about 25-35 hours, mainly in the expired air. Administration of this ketone to rabbits increased the glucuronic acid output. It has been suggested that MIPK is a normal constituent of human urine.

Irritating to the eyes, nose, throat, upper respiratory tract, and skin. (USCG, 1999)

Eye: If this chemical contacts the eyes, immediately wash the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately. Contact lenses should not be worn when working with this chemical. Skin: If this chemical contacts the skin, immediately wash the contaminated skin with soap and water. If this chemical penetrates the clothing, immediately remove the clothing, wash the skin with soap and water, and get medical attention promptly. Breathing: If a person breathes large amounts of this chemical, move the exposed person to fresh air at once. If breathing has stopped, perform mouth-to-mouth resuscitation. Keep the affected person warm and at rest. Get medical attention as soon as possible. Swallow: If this chemical has been swallowed, get medical attention immediately. (NIOSH, 2016)|(See procedures)

Fresh air, rest. Refer for medical attention.

Remove contaminated clothes. Rinse and then wash skin with water and soap.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Ketones and related compounds/|Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . For contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Ketones and related compounds/|Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Ketones and related compounds/

/HUMAN EXPOSURE STUDIES/ A maximization test performed on 25 human volunteers using a 10% methyl isopropyl ketone solution in petrolatum produced no sensitization reaction.

2-isopentanone

The substance can be absorbed into the body by inhalation of its vapour.|inhalation, ingestion, skin and/or eye contact

irritation eyes, skin, mucous membrane, respiratory system; cough

Cough. Dizziness. Headache. Nausea. Drowsiness.

Redness. Dry skin.

Redness. Pain.

Eyes, skin, respiratory system

All other basic organic chemical manufacturing|2-Butanone, 3-methyl-: ACTIVE|Synthetic, also by fermentation.

Food additives -> Flavoring Agents|Fatty Acyls [FA] -> Oxygenated hydrocarbons [FA12]|Fire Hazards -> Flammable - 3rd degree

Flavoring Agents