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Lysergol

Lysergol structure

CAS No:
602-85-7
Formula:
C16H18N2O
Chemical Name:
Lysergol
Synonyms:
Ergoline-8-methanol,9,10-didehydro-6-methyl-,(8β)-;Ergoline-8β-methanol,9,10-didehydro-6-methyl-;Lysergol;Indolo[4,3-fg]quinoline,ergoline-8-methanol deriv.;(8β)-9,10-Didehydro-6-methylergoline-8-methanol;NSC 196867;(+)-Lysergol;1413-67-8;607362-34-5
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Lysergol, a clavine alkaloid isolated from seeds of Ipomoea muricata, is a bioenhancer for the drugs and nutrients and has antibacterial activity. Lysergol has been used as hypotensive, psychotropic analgesic and uterus- and intestine-stimulating drug[1][2].

Lysergol is an alkaloid of the ergoline family that occurs as a minor constituent in some species of fungi and in the morning glory family of plants. Its structure is that of ergoline with a methyl group at N-6 and a beta-hydroxymethyl substituent at C-8.

Lysergol Basic Attributes

Molecular Weight：

254.333

Exact Mass：

254.33

EC Number：

210-024-5

UNII：

NTR684Z1AZ

Characteristics

PSA：

39.3

XLogP3：

1.76

Density：

1.3±0.1 g/cm3

Melting Point：

253-255 °C

Boiling Point：

465.8±40.0 °C at 760 mmHg

Flash Point：

235.5±27.3 °C

Refractive Index：

1.710

Safety Information

Packing level：

Hazard category：

6.1(a)

Transport codes：

UN 1544

hazard class code：

R26/27/28

safety instructions：

26-36/37/39-45

Marks：

T+

Precautionary statement(s)：

P261, P264, P270, P271, P280, P301+P310, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H300

GHS Classification：

|Danger|H300 (97.44%): Fatal if swallowed [Danger Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P310, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 39 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)

MeSH Entry Terms：

9,10-Didehydro-6-methylergoline-8b-methanol

Lysergol Use and Manufacturing

Lysergol is an ergot alkaloid which when used in combination with antibiotic nalidixic acid, can effectively inhibit Escherichia coli. It also maintains the potential to act on the 5-HT1/2 receptors and at α1-adrenergic receptors thus acting as a neuropsychiatric drug.

Computed Properties

Molecular Weight:254.33
XLogP3:2.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:254.141913202
Monoisotopic Mass:254.141913202
Topological Polar Surface Area:39.3
Heavy Atom Count:19
Complexity:394
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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