 Home > Encyclopedia > (+)-Propranolol

(+)-Propranolol

(+)-Propranolol structure

CAS No:
5051-22-9
Formula:
C16H21NO2
Chemical Name:
(+)-Propranolol
Synonyms:
2-Propanol,1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)-,(2R)-;2-Propanol,1-(isopropylamino)-3-(1-naphthyloxy)-,(+)-;2-Propanol,1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)-,(R)-;(2R)-1-[(1-Methylethyl)amino]-3-(1-naphthalenyloxy)-2-propanol;(+)-Propranolol;d-Propranolol;Dexpropranolol;Dextropropranolol;(R)-Propranolol;(2R)-Propranolol;(+)-(R)-Propranolol;(R)-(+)-Propranolol
Categories:
Organic Chemistry > Amides

Description

(R)-(+)-propranolol is a propranolol.|A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.

(+)-Propranolol Basic Attributes

Molecular Weight：

295.80438

Exact Mass：

259.34

EC Number：

225-749-2

UNII：

PG6KY07UD7

DSSTox ID：

DTXSID3045304

HScode：

2922509090

Characteristics

PSA：

41.49000

XLogP3：

3.77040

Density：

1.093 g/cm3

Melting Point：

96 °C

Boiling Point：

434.9ºC at 760 mmHg

Flash Point：

216.8ºC

Refractive Index：

1.58

Storage Conditions：

Store at RT

Drug Information

MeSH：

Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety. (See all compounds classified as Adrenergic beta-Antagonists.)|Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents.)|Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)|Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)

Metabolism/Metabolites：

Dexpropranolol (propranolol) has known human metabolites that include 4-Hydroxypropranolol, 5-Hydroxypropranolol, and N-Desisopropylpropranolol.

MeSH Entry Terms：

Anaprilin

Computed Properties

Molecular Weight:259.34
XLogP3:3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:6
Exact Mass:259.157228913
Monoisotopic Mass:259.157228913
Topological Polar Surface Area:41.5
Heavy Atom Count:19
Complexity:257
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes