Nε-(Carboxymethyl)lysine
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Nε-(Carboxymethyl)lysine
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CAS No:
5746-04-3
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Formula:
C8H16N2O4
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Chemical Name:
Nε-(Carboxymethyl)lysine
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Synonyms:
L-Lysine,N6-(carboxymethyl)-;Lysine,N6-(carboxymethyl)-,L-;N6-(Carboxymethyl)-L-lysine;N6-(Carboxymethyl)lysine;ε-(Carboxymethyl)lysine;Nε-(Carboxymethyl)lysine;(2S)-2-Amino-6-(carboxymethylamino)hexanoic acid
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CAS No:
Description
Off-White Solid
N(6)-carboxymethyl-L-lysine is an L-lysine derivative with a carboxymethyl substituent at the N(6)-position. It has a role as an antigen. It is a L-lysine derivative and a non-proteinogenic L-alpha-amino acid.|N(6)-Carboxymethyllysine is a lysine derivative found in proteins where the epsilon nitrogen of the amino acid residue is modified by a carboxymethyl group. This advanced glycation end product (AGE) is elevated in certain diseases and is associated with aging.
Characteristics
112.65000
-1.16
Off-white solid
1.3±0.1 g/cm3
176-180 °C (decomp)
428.9±45.0 °C at 760 mmHg
213.2±28.7 °C
1.518
Hygroscopic, -20ºC Freezer, Under Inert Atmosphere
Nε-(Carboxymethyl)lysine Use and Manufacturing
CEL and CML are two stable, nonenzymatic chemical modifications of protein lysine residues resulting from glycation and oxidation reactions.
Computed Properties
Molecular Weight:204.22
XLogP3:-5.2
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:8
Exact Mass:204.11100700
Monoisotopic Mass:204.11100700
Topological Polar Surface Area:113
Heavy Atom Count:14
Complexity:196
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes