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Pamabrom

Pamabrom structure

CAS No:
606-04-2
Formula:
C7H7BrN4O2.C4H11NO
Chemical Name:
Pamabrom
Synonyms:
1H-Purine-2,6-dione,8-bromo-3,9-dihydro-1,3-dimethyl-,compd. with 2-amino-2-methyl-1-propanol (1:1);Theophylline,8-bromo-,compd. with 2-amino-2-methyl-1-propanol (1:1);1H-Purine-2,6-dione,8-bromo-3,7-dihydro-1,3-dimethyl-,compd. with 2-amino-2-methyl-1-propanol (1:1);1-Propanol,2-amino-2-methyl-,compd. with 8-bromotheophylline (1:1);1-Propanol,2-amino-2-methyl-,compd. with 8-bromo-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione (1:1);2-Amino-2-methyl-1-propanol 8-bromotheophyllinate;Pamabrom;Predema;Sunril;Premsyn PMS
Categories:
Analytical Chemistry > Analysis Reagents

Description

Pamabron is a common over-the-counter diuretic used for relief of menstrual-associated symptoms. The active diuretic ingredient in pamabrom is 8-bromotheophylline. Pamabrom is available in combination with acetaminophen (paracetamol) for various conditions such as back pain and menstrual relief. The acetaminophen helps reduce menstrual pains and the pamabrom reduces associated bloating.

Pamabrom is a mixture containing 2-amino-2-methyl-1-propanol and 8-bromotheophylline (a methylxanthine) in a 1:1 ratio, with mild diuretic activity.

Pamabrom Basic Attributes

Molecular Weight：

348.2

Exact Mass：

347.05900

EC Number：

210-103-4

UNII：

UA8U0KJM72

DSSTox ID：

DTXSID80209397

NCI Thesaurus Code：

C81076

Characteristics

PSA：

116

XLogP3：

0.13910

Appearance：

COA

Melting Point：

300 °C (decomp)

Boiling Point：

469.5ºC at 760 mmHg

Flash Point：

237.7ºC

Storage Conditions：

Refrigerator

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

Marks：

Precautionary statement(s)：

P264, P270, P301+P312, P330, P501

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 39 companies from 1 notifications to the ECHA C&L Inventory.

Drug Information

MeSH Entry Terms：

2-amino-2-methyl-1-propanol-8-bromotheophyllinate

Pamabrom Use and Manufacturing

A diuretic used to reduce menstrual pains.

Computed Properties

Molecular Weight:348.20
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:347.05930
Monoisotopic Mass:347.05930
Topological Polar Surface Area:116
Heavy Atom Count:20
Complexity:340
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Unspecified

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Pamabrom
Manufacturer	Germany Pharmaceutical Co., Ltd.

Paracetamol and Pamagallo
Ingredients	This product is a compound preparation, its components are: each tablet contains 500 mg of acetaminophen and 25 mg of pamabrom.
Indication	1. Long-term drinking or combined use of sedatives, analgesics or other psychotropic drugs, other liver enzyme inducers, especially patients using barbiturates or anticonvulsants, will cause acute poisoning. When this product is used for a long time or in large quantities, there is a greater risk of liver toxicity. 2. When this product is used in combination with chloramphenicol, it can prolong the latter's half-life and enhance its toxicity. 3. When used in combination with anticoagulants, it can enhance the anticoagulant effect, so the dosage of the anticoagulant should be adjusted. 4. When used in combination with aspirin or other non-steroidal anti-inflammatory drugs for a long time and in large quantities, there is a significant risk of increased renal toxicity. 5. When this product is used in combination with the antiviral drug zidovudine, its toxicity can be increased, and simultaneous use should be avoided. 6. When this product is used in combination with central nervous system depressants (such as diazepam), it has enhanced sedative and analgesic effects, and the dosage should be appropriately reduced. When used in combination with barbiturates
Specifications	Each tablet contains 500mg of acetaminophen and 25mg of pamabrom
Manufacturer	Germany Pharmaceutical Co., Ltd.

Registered Holders

Germany Pharmaceutical Co., Ltd.

China
Active
Guangzhou Green Cross Pharmaceutical Co., Ltd.

China
Active
KNOLL AG LUDWIGSHAFEN

United States
Inactive

Recommended Suppliers of Pamabrom

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

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Pamabrom

CAS No.: 606-04-2

Content: 99.00%

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Guide of Pamabrom

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
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Pamabrom

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