2-Chloro-1,3-dinitrobenzene

202.552

202.55

210-107-6

LG72RND0AB

105590|21276

DTXSID3041378

Yellow crystals from benzene

2904902000

91.64000

1.79

orange yellow aciform crystal

1.6867 g/cm³ @ Temp: 16.5 °C

86-87 °C

315 °C

142.4±22.3 °C

1.625

Soluble in alcohol. Moderately soluble in benzene, ether. Practically insoluble in water.

II

6.1

3441

R23/24/25;R33;R50/53

S28-S36/37-S45-S60-S61

CZ0525500

P260, P264, P270, P271, P273, P280, P284, P301+P310, P302+P352, P304+P340, P310, P312, P314, P320, P321, P322, P330, P361, P363, P391, P403+P233, P405, P501

H301

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P260, P264, P270, P271, P273, P280, P284, P301+P310, P302+P352, P304+P340, P310, P312, P314, P320, P321, P322, P330, P361, P363, P391, P403+P233, P405, and P501|Aggregated GHS information provided by 4 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Wear appropriate equipment to prevent reasonable probability of skin contact; wear eye protection to prevent reasonable probability of eye contact. /Dinitrobenzene/|Respirator selection: Upper limit devices recommended by OSHA: 5 mg/cu m: any dust and mist respirator except single-use respirators; 10 mg/cu m: any dust and mist respirator except single-use and quarter-mask respirators or any supplied air respirator or high-efficiency particulate filter or any self-contained breathing apparatus; 25 mg/cu m: any powdered air-purifying respirator with a dust and mist filter or any supplied-air respirator operated in a continuous flow mode; 50 mg/cu m: high-efficiency particulate filter or any powered air-purifying respirator with a tight-fitting facepiece and a high-efficiency particulate filter or any self-contained breathing apparatus with a full facepiece or any supplied-air respirator with a full facepiece or any supplied-air respirator with a tight-fitting facepiece operated in a continuous flow mode; 200 mg/cu m: any supplied-air respirator with a half-mask and operated in a pressure-demand or other positive pressure mode; Emergency or planned entry in unknown concn or IDLH conditions: any self-contained breathing apparatus with a full facepiece and operated in a pressure-demand or other positive pressure mode or any supplied-air respirator with a full facepiece and operated in a pressure-demand or other positive pressure mode in combination with an auxiliary self-contained breathing apparatus operated in pressure-demand or other positive pressure mode; escape: any air-purifying full facepiece respirator with a high-efficiency particulate filter or any appropriate escape-type self-contained breathing apparatus. /Dinitrobenzene/

Employees should wash immediately when skin becomes wet, and promptly when skin becomes contaminated; Work clothing should be changed daily if it is reasonably probable that the clothing is contaminated; Remove clothing: immediately remove any non-impervious clothing that becomes wet, and promptly remove any non-impervious clothing that becomes contaminated. /Dinitrobenzene/|The following equipment should be available: quick drench. /Dinitrobenzene/|SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Health: TOXIC; inhalation, ingestion, or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. /Chlorodinitrobenzenes; Chlorodinitrobenzenes, liquid; Chlorodinitrobenzenes, solid/|/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Fire or Explosion: Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards. Those substances designated with a "P" may polymerize explosively when heated or involved in a fire. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form. /Chlorodinitrobenzenes; Chlorodinitrobenzenes, liquid; Chlorodinitrobenzenes, solid/|/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Public Safety: CALL Emergency Response Telephone Number ... . As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate enclosed areas. /Chlorodinitrobenzenes; Chlorodinitrobenzenes, liquid; Chlorodinitrobenzenes, solid/|/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible. /Chlorodinitrobenzenes; Chlorodinitrobenzenes, liquid; Chlorodinitrobenzenes, solid/|For more DOT Emergency Guidelines (Complete) data for 1-CHLORO-2,6-DINITROBENZENE (8 total), please visit the HSDB record page.

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./|The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.|The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

SKIN IRRITANT.

EXPTL USE: 42 PATIENTS WITH ALOPECIA AREATA WERE TREATED WITH LOCAL APPLICATIONS OF DINITROCHLOROBENZENE AVAILABLE IN 2 FORMS, AN ACETONE SOLN APPLIED WEEKLY OR A CREAM USED EVERY DAY, EMPLOYING A WIDE RANGE OF DINITROCHLOROBENZENE CONCN. CONCN USED VARIED @ EACH APPLICATION TO PRODUCE A CONTACT DERMATITIS. A FEW PATIENTS EXPERIENCED COMPLETE AND LASTING HAIR REGROWTH, 17 HAD POOR RESULTS, AND IN 18 THE TREATMENT WAS A FAILURE.|EXPTL USE: 18 PATIENTS WITH MULTIPLE RECURRENCES OF MALIGNANT MELANOMA WITHOUT EVIDENT DISTANT SPREAD WERE RANDOMLY ASSIGNED TO TREATMENT WITH EITHER INTRALESIONAL BACILLUS CALMETTE-GUERIN OR INTRALESIONAL DINITROCHLOROBENZENE. BOTH AGENTS WERE ABLE TO DESTROY APPROX 90% OF THE INJECTED INTRADERMAL NODULES.|EXPTL USE: SINCE DINITROCHLORBENZENE INCITES VIGOROUS T-LYMPHOCYTE & MONOCYTE REACTION @ SITE OF APPLICATION, TOPICAL ADMIN OF THIS CHEMICAL IN PREVIOUSLY SENSITIZED PATIENTS CAN BE USED TO RECRUIT CYTOTOXIC CELLS TO AN AREA OF LOCAL TUMOR, FUNGUS, OR VIRAL INFECTION. CURRENTLY ... CLEARLY INVESTIGATIONAL. /DINITROCHLOROBENZENE/

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patent can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Aniline and related compounds/|Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious. Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Administer 1% solution methylene blue if patient is symptomatic with severe hypoxia, cyanosis, and cardiac compromise not responding to oxygen. ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Aniline and related compounds/

... CHRONIC POISONING BY INDUSTRIAL EXPOSURE ... CAUSE GRADUAL ONSET OF SYMPTOMS OF RETROBULBAR NEURITIS, WITH BLURRING OF VISION, CENTRAL SCOTOMA, ESPECIALLY FOR GREEN, & CONSTRICTION OF VISUAL FIELDS. @ FIRST OPHTHALMOSCOPIC FINDINGS ARE NORMAL, BUT OPTIC NEURITIS MAY GRADUALLY BECOME EVIDENT ... . /DINITROCHLOROBENZENE/|CHRONIC POISONING BY INDUSTRIAL EXPOSURE ... IMPAIRED PUPILLARY REACTION IN ACCOMMODATION HAS BEEN NOTED DESPITE GOOD PUPILLARY RESPONSE TO LIGHT. TYPICALLY THE RETROBULBAR NEURITIS HAS BEEN ASSOCIATED WITH PERIPHERAL NEURITIS MANIFEST AS PARESTHESIAS & PAINS IN LEGS & BURNING OF FEET. /DINITROCHLOROBENZENE/

Benzene, 2-chloro-1,3-dinitro-: INACTIVE|THE MIXT OF 2,4- AND 2,6-DINITROCHLOROBENZENES (OF WHICH THE 2,4-CMPD IS PRESENT IN LARGEST AMT) CAN BE SEPARATED WITH AN ALKALINE ETHANOL-WATER SOLN.|Commercial chlorodinitrobenzene is usually mixt of six possible isomers, which are closely related chemically and physically to each other. /Chlorodinitrobenzenes/|CHLORODINITROBENZENE IS...ENCOUNTERED AS AN INT IN MFR OF PICRIC ACID, AND FORMERLY EMPLOYED IN COMBINATION WITH DINITROBENZENE IN AN EXPLOSIVE KNOWN AS ROBURITE.